Radial maze proficiency of adult Wistar rats given prenatal complex magnetic field treatments

McKay, Bruce E.; St-Pierre, Linda S.; Persinger, Michael A.

doi:10.1002/dev.10072

Cited by 12 publications

(13 citation statements)

References 28 publications

(33 reference statements)

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“…We selected these rats because of their conspicuous anomalous behaviors in other tasks (McKay et al 2003) that were not observed in the rats exposed to the simple frequencymodulated field. After weaning the rats had been maintained in plastic cages, 4 rats of the same sex per cage.…”

Section: Blood Chemistrymentioning

confidence: 99%

Altered blood chemistry and hippocampal histomorphology in adult rats following prenatal exposure to physiologically-patterned, weak (50–500 nanoTesla range) magnetic fields

St-Pierre

Mazzuchin

Persinger

2008

International Journal of Radiation Biology

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Section: Blood Chemistrymentioning

confidence: 99%

Altered blood chemistry and hippocampal histomorphology in adult rats following prenatal exposure to physiologically-patterned, weak (50–500 nanoTesla range) magnetic fields

St-Pierre

Mazzuchin

Persinger

2008

International Journal of Radiation Biology

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“…We (McKay, St-Pierre, & Persinger, 2001;Persinger, St-Pierre, & Koren, 2001) have found that rats exposed prenatally to complex (temporally asymmetric and physiologically relevant) magnetic fields exhibited marked hyperactivity as weanlings and impoverished associative memory as adults. The specific deficits reported in these studies were always specific to the shape of the applied waveform.…”

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confidence: 99%

BEHAVIORAL EFFECTS OF COMBINED PERINATAL L-NAME AND 0.5 Hz MAGNETIC FIELD TREATMENTS

McKay

Koren

Persinger

2003

International Journal of Neuroscience

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The behavioral effects of the nitric oxide synthase inhibitor N-nitro-Larginine methyl ester (L-NAME), when perinatally (2 d prenatal-14 d postnatal) co-administered with extremely low frequency magnetic fields,were examined in weanling and adult rats. Litters of rat pups and their dams were exposed continuously to biphasic pulsed fields presented once every 2 s. The magnetic fields were amplitude modulated in successively increasing and decreasing steps (each 30 min) between 0 and 1.8 microT or between 0 to 13 nanoT (reference field) during 4-h periods (6 periods per day). These two treatments were subdivided into dams that received tap water and dams that received 1.0 g/L L-NAME in tap water. The behavioral sequelae to these treatments for 242 progeny from 41 litters were followed from weaning (1 wk after termination of treatment) into adulthood. Compared to exposures to water and nanoT magnetic fields, perinatal exposures to the microT magnetic fields or to L-NAME in the maternal water supply were associated with increased activity levels when the rats were tested as weanlings, but decreased activity levels when the rats were tested as adults. However, the activity of rats that received the combination of L-NAME and microT magnetic

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“…In general, the biologic effects reported in many studies have not confi rmed any particular pathologic effect even after prolonged exposures to high-strength fi elds (100 kV/m) or high-intensity magnetic fi elds (10 mT) (16 An early behavioral study of Persinger has been repeated by Rudolph et al and Thomas et al who found that an exposure of rats to weak oscillating MF (typically of 50 Hz) modifi es their open fi eld response in particular by increasing their rearing activity which is involved in exploration and also stress-related anxious behavior (17,18).…”

Section: Discussionmentioning

confidence: 99%

The 50 Hz (10 mT) sinusoidal magnetic field: effects on stress-related behavior of rats

Ma¹,

Mt²,

Tuncel³

2012

BLL

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Abstract:Purpose: The purpose of this study was to investigate the behavioral changes induced by 50 Hz, 10 mT fl ux density Sinusoidal Magnetic Field (MF). Material and methods: Seventy-six young adult male Wistar albino rats were used in the study. They were separated into two groups: control group (C) n = 38; MF group n = 38. C animals were left under the same conditions with the MF group for 21 days but with prevented or avoided exposure to MF. Anxiety and stress-related behavioral changes were investigated by elevated plus-maze and hole-board systems. Just before being tested in the maze, each animal was tested by means of the hole-board method in order to separate the directed exploration behavior and locomotion activity changes from anxiety-related behavior. Results: In the hole-board system parameters there were no statistically signifi cant differences between the two groups. There was a statistically signifi cant difference between MF and C groups when the ratio of time spent on open arms to the total time spent on all arms was evaluated (0.12 ± 0.08 and 0.34 ± 0.18 respectively and p < 0.01). Conclusion: Our results suggest that after 21 days, a continuous exposure to extremely low frequency of magnetic fi eld (50 Hz, 10 mT) has no signifi cant effect on activity and exploration activity but signifi cantly induces stress and anxiety-related behavior in rats (Tab. 2, Fig. 9, Ref. 19 Static, sinusoidal and specifi c pulsed magnetic fi elds have been shown to alter the animal and human behaviors such as directional orientation, learning, pain perception (nociception) and anxietyrelated behaviors (1 -6).Extremely low frequency (0.1 -100 Hz) of sinusoidal magnetic fi elds (MF) of 50 or 60 Hertz generated predominantly by power lines, appliances and video display terminals could endanger health by producing a variety of effects in biological systems. Appliances can generate fi elds higher than those of transmission lines but in most cases they fall off rapidly. However electric blankets expose the users for eight hours at a time and electric hair dryers and shavers are operated close to the body. Power frequency fi elds carry too little energy in each quantum to break the chemical and molecular bonds, so they are not accepted as a sort of biological damage such as caused by X-rays, but on the other hand they are supposed to induce currents and create potential differences in biological structures.Although the present knowledge is fragmentary and the coherent theory to explain the observations seems far off, continuously present power frequency fi elds in our modern environment bring about potential health effects which are a matter of serious scientifi c and public health policy concern.That concern is focused on cancer and developmental abnormalities and to a lesser extent on endocrine and nervous system and psychiatric problems including anxiety disorders and depression (7 -9).The general aim of our studies is to assess the psychological and psychophysiological effects of low-intensity 50 Hz MF exposure. I...

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Radial maze proficiency of adult Wistar rats given prenatal complex magnetic field treatments

Cited by 12 publications

References 28 publications

Altered blood chemistry and hippocampal histomorphology in adult rats following prenatal exposure to physiologically-patterned, weak (50–500 nanoTesla range) magnetic fields

Altered blood chemistry and hippocampal histomorphology in adult rats following prenatal exposure to physiologically-patterned, weak (50–500 nanoTesla range) magnetic fields

BEHAVIORAL EFFECTS OF COMBINED PERINATAL L-NAME AND 0.5 Hz MAGNETIC FIELD TREATMENTS

The 50 Hz (10 mT) sinusoidal magnetic field: effects on stress-related behavior of rats

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