Radial Glial Fibers Promote Neuronal Migration and Functional Recovery after Neonatal Brain Injury

Jinnou, Hideo; Sawada, Masato; Kawase, Kengo; Kaneko, Naoko; Herranz-Pérez, Vicente; Miyamoto, Takuya; Kawaue, Takumi; Miyata, Takaki; Tabata, Yasuhiko; Akaike, Toshihiro; García‐Verdugo, José Manuel; Ajioka, Itsuki; Saitoh, Shinji; Sawamoto, Kazunobu

doi:10.1016/j.stem.2017.11.005

Cited by 71 publications

(96 citation statements)

References 43 publications

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“…Our study showed that radial glial fibers are transiently maintained after neonatal brain injury, but not after adult brain injury (Jinnou et al . ). Although the mechanisms of radial glial maintenance are unknown, fibroblast growth factor signaling might be involved in maintaining radial glial fibers after chronic neonatal hypoxia (Ganat et al .…”

Section: Neuronal Migration After Neonatal Brain Injurymentioning

confidence: 97%

“…This N‐cadherin‐containing scaffold promoted SEZ‐derived neuroblast migration in the injured brain (Jinnou et al . ). Moreover, the transplanted N‐cadherin‐containing scaffold within the lesion promoted SEZ‐derived neuronal maturation and successfully improved gait disturbance in neonatal mice, but not in adult mice.…”

Section: Enhancement Of Neuronal Migration and Perspectivesmentioning

confidence: 97%

“…This disrupts the fiber‐guided migration of SEZ‐derived neuroblasts toward the site of injury, without changing the morphology of the radial glial fibers (Jinnou et al . ), suggesting that the association of radial glia with migrating neuroblasts in both the embryonic brain and in the postnatal injured brain are controlled by a common mechanism. Furthermore, we found that neonatal radial glia promote the migration speed of SEZ‐derived neuroblasts by decreasing the resting‐phase duration and increasing stride length.…”

Section: Neuronal Migration After Neonatal Brain Injurymentioning

confidence: 99%

“…; Jinnou et al . ), this raises the possibility of reconstructing blood vessel or radial glial scaffolds as a strategy for promoting endogenous neuronal regeneration. We have demonstrated that transplanting a laminin‐rich porous sponge into the injured brain enhances the migration of neuroblasts toward the injured site without causing further post‐injury inflammation (Ajioka et al .…”

Section: Enhancement Of Neuronal Migration and Perspectivesmentioning

confidence: 99%

“…We demonstrated that genetic ablation of newly generated SEZ‐derived interneurons around the brain lesion decreased functional recovery by the N‐cadherin‐containing scaffold (Jinnou et al . ), suggesting that SEZ‐derived neurogenesis contributes to functional recovery. In addition, cell transplantation studies showed that interneuron regeneration can promote functional recovery in the spinal cord (Bráz et al .…”

Section: Enhancement Of Neuronal Migration and Perspectivesmentioning

confidence: 99%

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Adult neurogenesis and its role in brain injury and psychiatric diseases

Hayashi

Jinnou

Sawamoto

et al. 2018

Journal of Neurochemistry

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In the adult mammalian brain, neural stem cells (NSCs) reside in two neurogenic regions, the walls of the lateral ventricles, and the subgranular zone of the hippocampus, which generate new neurons for the olfactory bulb and dentate gyrus, respectively. These adult NSCs retain their self-renewal ability and capacity to differentiate into neurons and glia as demonstrated by in vitro studies. However, their contribution to tissue repair in disease and injury is limited, lending credence to the claim by prominent neuropathologist Ramón y Cajal that 'once development was ended, the founts of growth and regeneration of the axons and dendrites dried up irrevocably'. However, recent progress toward understanding the fundamental biology of adult NSCs and their role in pathological conditions has provided new insight into the potential therapeutic utility of endogenous NSCs. In this short review, we highlight two topics: the altered behavior of NSCs after brain damage and the dysfunction of NSCs and oligodendrocyte precursor cells, another type of undifferentiated cell in the adult brain, in mood affective disorders.

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Section: Neuronal Migration After Neonatal Brain Injurymentioning

confidence: 97%

Section: Enhancement Of Neuronal Migration and Perspectivesmentioning

confidence: 97%

Section: Neuronal Migration After Neonatal Brain Injurymentioning

confidence: 99%

Section: Enhancement Of Neuronal Migration and Perspectivesmentioning

confidence: 99%

Section: Enhancement Of Neuronal Migration and Perspectivesmentioning

confidence: 99%

See 3 more Smart Citations

Adult neurogenesis and its role in brain injury and psychiatric diseases

Hayashi

Jinnou

Sawamoto

et al. 2018

Journal of Neurochemistry

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Heterogeneous distribution of doublecortin‐expressing cells surrounding the rostral migratory stream in the juvenile mouse

Aoyagi

Hibi

Kimori

et al. 2018

J of Comparative Neurology

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In the postnatal mammalian brain, neural stem cells of the ventricular-subventricular zone continue to generate doublecortin (Dcx)-expressing immature neurons. Throughout life, these immature neurons migrate to the olfactory bulb through the rostral migratory stream (RMS). In this study, we investigated the distribution of these putative immature neurons using enhanced green fluorescent protein (EGFP) expression in the area surrounding the RMS of the juvenile Dcx-EGFP mice. Through the combined use of an optical clearing reagent (a 2,2'-thiodiethanol solution) and two-photon microscopy, we visualized three-dimensionally the EGFP-positive cells in the entire RMS and its surroundings. The resulting wide-field and high-definition images along with computational image processing methods developed in this study were used to comprehensively determine the position of the EGFP-positive cells. Our findings revealed that the EGFP-positive cells were heterogeneously distributed in the area surrounding the RMS. In addition, the orientation patterns of the leading process of these cells, which displayed the morphology of migrating immature neurons, differed depending on their location. These novel results provide highly precise morphological information for immature neurons and suggest that a portion of immature neurons may be detached from the RMS and migrate in various directions.

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Specific knockout of Sox2 in astrocytes reduces reactive astrocyte formation and promotes recovery after early postnatal traumatic brain injury in mouse cortex

Liu

Hong

Gong

et al. 2022

Glia

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In response to central nervous system (CNS) injury, astrocytes go through a series of alterations, referred to as reactive astrogliosis, ranging from changes in gene expression and cell hypertrophy to permanent astrocyte borders around stromal cell scars in CNS lesions. The mechanisms underlying injury-induced reactive astrocytes in the adult CNS have been extensively studied. However, little is known about injuryinduced reactive astrocytes during early postnatal development. Astrocytes in the mouse cortex are mainly produced through local proliferation during the first 2 weeks after birth. Here we show that Sox2, a transcription factor critical for stem cells and brain development, is expressed in the early postnatal astrocytes and its expression level was increased in reactive astrocytes after traumatic brain injury (TBI) at postnatal day (P) 7 in the cortex. Using a tamoxifen-induced hGFAP-CreERT2; Sox2 flox/flox ; Rosa-tdT mouse model, we found that specific knockout of Sox2 in astrocytes greatly inhibited the proliferation of reactive astrocytes, the formation of glia limitans borders and subsequently promoted the tissue recovery after postnatal TBI at P7 in the cortex. In addition, we found that injury-induced glia limitans borders were still formed at P2 in the wild-type mouse cortex, and knockout of Sox2 in astrocytes inhibited the reactivity of both astrocytes and microglia. Together, these findings provide evidence that Sox2 is essential for the reactivity of astrocytes in response to the cortical TBI during the early postnatal period and suggest that Sox2-dependent astrocyte reactivity is a potential target for therapeutic treatment after TBI.

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Radial Glial Fibers Promote Neuronal Migration and Functional Recovery after Neonatal Brain Injury

Cited by 71 publications

References 43 publications

Adult neurogenesis and its role in brain injury and psychiatric diseases

Adult neurogenesis and its role in brain injury and psychiatric diseases

Heterogeneous distribution of doublecortin‐expressing cells surrounding the rostral migratory stream in the juvenile mouse

Specific knockout of Sox2 in astrocytes reduces reactive astrocyte formation and promotes recovery after early postnatal traumatic brain injury in mouse cortex

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