Adult neurogenesis and its role in brain injury and psychiatric diseases

Hayashi, Yoshitaka; Jinnou, Hideo; Sawamoto, Kazunobu; Hitoshi, Seiji

doi:10.1111/jnc.14557

Cited by 46 publications

(20 citation statements)

References 132 publications

(262 reference statements)

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“…Growing evidence indicates that neurogenesis in the adult brain has been implicated in physiological brain function, such as learning and memory [ 31 ]. In addition, possible roles of adult neurogenesis in the pathogenesis of brain injury, neurodegenerative and psychiatric diseases have been extensively investigated [ 32 , 33 ]. In the adult rodent brain, neurogenic region is restricted in hippocampal DG and SVZ lining the lateral ventricles [ 31 ].…”

Section: Bdnf and Adult Neurogenesismentioning

confidence: 99%

Actions of Brain-Derived Neurotrophin Factor in the Neurogenesis and Neuronal Function, and Its Involvement in the Pathophysiology of Brain Diseases

Numakawa

Odaka

Adachi

2018

IJMS

232

138

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It is well known that brain-derived neurotrophic factor, BDNF, has an important role in a variety of neuronal aspects, such as differentiation, maturation, and synaptic function in the central nervous system (CNS). BDNF stimulates mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK), phosphoinositide-3kinase (PI3K), and phospholipase C (PLC)-gamma pathways via activation of tropomyosin receptor kinase B (TrkB), a high affinity receptor for BDNF. Evidence has shown significant contributions of these signaling pathways in neurogenesis and synaptic plasticity in in vivo and in vitro experiments. Importantly, it has been demonstrated that dysfunction of the BDNF/TrkB system is involved in the onset of brain diseases, including neurodegenerative and psychiatric disorders. In this review, we discuss actions of BDNF and related signaling molecules on CNS neurons, and their contributions to the pathophysiology of brain diseases.

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Section: Bdnf and Adult Neurogenesismentioning

confidence: 99%

Actions of Brain-Derived Neurotrophin Factor in the Neurogenesis and Neuronal Function, and Its Involvement in the Pathophysiology of Brain Diseases

Numakawa

Odaka

Adachi

2018

IJMS

232

138

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“…Chronic stress decreases the proliferation of NSC and the survival of newborn neurons in the adult DG [ 113 , 114 ]. Moreover, stress-induced deficits of AHN have been linked with affective dysfunction in animal models across species [ 113 , 115 , 116 , 117 ]. While AHN defects per se do not cause affective dysfunction [ 118 , 119 ], several anti-depressants increase AHN, and the beneficial effects of fluoxetine on depressive behavior depended at least in part on neurogenesis [ 120 , 121 ].…”

Section: Psychological Stress-induced Ahn Defects and Mood Disordementioning

confidence: 99%

Mitochondrial and Autophagic Regulation of Adult Neurogenesis in the Healthy and Diseased Brain

Büeler

2021

IJMS

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Adult neurogenesis is a highly regulated process during which new neurons are generated from neural stem cells in two discrete regions of the adult brain: the subventricular zone of the lateral ventricle and the subgranular zone of the dentate gyrus in the hippocampus. Defects of adult hippocampal neurogenesis have been linked to cognitive decline and dysfunction during natural aging and in neurodegenerative diseases, as well as psychological stress-induced mood disorders. Understanding the mechanisms and pathways that regulate adult neurogenesis is crucial to improving preventative measures and therapies for these conditions. Accumulating evidence shows that mitochondria directly regulate various steps and phases of adult neurogenesis. This review summarizes recent findings on how mitochondrial metabolism, dynamics, and reactive oxygen species control several aspects of adult neural stem cell function and their differentiation to newborn neurons. It also discusses the importance of autophagy for adult neurogenesis, and how mitochondrial and autophagic dysfunction may contribute to cognitive defects and stress-induced mood disorders by compromising adult neurogenesis. Finally, I suggest possible ways to target mitochondrial function as a strategy for stem cell-based interventions and treatments for cognitive and mood disorders.

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“…Thus, hippocampal proximity to immune infiltration sites could partially explain the susceptibility to NPSLE in this setting. Secondly, the hippocampus is a zone of prominent neurogenesis containing proliferating and maturing cell populations [ 184 , 185 , 186 ]. In MRL/lpr mice, replicating neuronal cells may display abnormal distribution throughout the CNS [ 187 ].…”

Section: Neuroinflammation In Lupus-prone Micementioning

confidence: 99%

From Systemic Inflammation to Neuroinflammation: The Case of Neurolupus

Bendorius

Muller

et al. 2018

IJMS

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It took decades to arrive at the general consensus dismissing the notion that the immune system is independent of the central nervous system. In the case of uncontrolled systemic inflammation, the relationship between the two systems is thrown off balance and results in cognitive and emotional impairment. It is specifically true for autoimmune pathologies where the central nervous system is affected as a result of systemic inflammation. Along with boosting circulating cytokine levels, systemic inflammation can lead to aberrant brain-resident immune cell activation, leakage of the blood–brain barrier, and the production of circulating antibodies that cross-react with brain antigens. One of the most disabling autoimmune pathologies known to have an effect on the central nervous system secondary to the systemic disease is systemic lupus erythematosus. Its neuropsychiatric expression has been extensively studied in lupus-like disease murine models that develop an autoimmunity-associated behavioral syndrome. These models are very useful for studying how the peripheral immune system and systemic inflammation can influence brain functions. In this review, we summarize the experimental data reported on murine models developing autoimmune diseases and systemic inflammation, and we explore the underlying mechanisms explaining how systemic inflammation can result in behavioral deficits, with a special focus on in vivo neuroimaging techniques.

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Adult neurogenesis and its role in brain injury and psychiatric diseases

Cited by 46 publications

References 132 publications

Actions of Brain-Derived Neurotrophin Factor in the Neurogenesis and Neuronal Function, and Its Involvement in the Pathophysiology of Brain Diseases

Actions of Brain-Derived Neurotrophin Factor in the Neurogenesis and Neuronal Function, and Its Involvement in the Pathophysiology of Brain Diseases

Mitochondrial and Autophagic Regulation of Adult Neurogenesis in the Healthy and Diseased Brain

From Systemic Inflammation to Neuroinflammation: The Case of Neurolupus

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