RAD51 135G/C polymorphism and breast cancer risk: a meta-analysis from 21 studies

Abstract

Growing evidence suggests that RAD51 plays a pivotal role in the repair of DNA double-strand breaks and the maintenance of genomic stability. A single nucleotide polymorphism, 135G/C, has been identified in the 5' untranslated region of the RAD51 gene and has been shown to influence gene transcription activity. Previous studies yielded conflicting results as to the association of 135G/C polymorphism with breast cancer. We aimed to assess the effect of 135G/C of RAD51 on breast cancer susceptibility with the use of a meta-analysis. We performed a meta-analysis of 21 published case-control studies up to April 2010. We found that the CC genotype was associated with a significantly increased risk of breast cancer when compared with the GG, CG, and CG/GG genotypes. Subgroup analyses showed that individuals carrying the CC genotype were associated with an elevated tumor risk in European populations and in sporadic breast cancer. After stratified analyses according to manuscript quality, the CC genotype was associated with a significantly increased risk of breast cancer compared with the CG genotype in studies of both higher and lower quality. However, significantly elevated risk was found in studies of higher quality, but not in studies of lower quality when homozygote and a recessive comparison model were tested. This meta-analysis indicates that RAD51 135G/C polymorphism may be identified as a susceptibility locus for breast cancer.

Single Nucleotide Polymorphisms in the Homologous Recombination Repair Genes and Breast Cancer Risk in Polish Women

“…Therefore, studies in different populations should be compared to justify this thesis (Brooks et al 2008;Jara et al 2010;Wang et al 2010;Gao et al 2011). Brooks et al (2008) showed that ethnicity was significantly associated with breast cancer risk and the genotype of RAD51 gene.…”

RAD51 genotype and triple-negative breast cancer (TNBC) risk in Polish women

“…It is known that RAD51 gene -135G>C polymorphism may contribute to breast cancer risk [13][14][15][16][17].…”

DNA Repair Perspectives in Thyroid and Breast Cancer: The Role of DNA Repair Polymorphisms

“…Thus, a meta-analysis of all results found until now might bring some more precise estimation of the association of this SNP with susceptibility to breast cancer. Recently, four important meta-analyses (Gao et al, 2011;Sun et al, 2011;Wang et al, 2010;Zhou et al, 2011), covering tens of other studies and thousands of subjects, were unanimous to state that the variant allele of RAD51 G135C may contribute to increased breast cancer susceptibility, which is in accordance with biological function study, which showed a more aggressive and poor prognosis phenotype (Costa et al, 2008). Zhou et al also reported that the C variant of this SNP is associated with an augmented breast cancer risk among the BRCA2 mutation carriers, but not BRCA1 .…”