RAD51 genotype and triple-negative breast cancer (TNBC) risk in Polish women

Smolarz, Beata; Zadrożny, Marek; Duda-Szymańska, Joanna; Makowska, Marianna; Samulak, Dariusz; Michalska, Magdalena; Mojs, Ewa; Bryś, Magdalena; Forma, Ewa; Romanowicz-Makowska, Hanna

doi:10.5114/pjp.2013.34602

Cited by 23 publications

(20 citation statements)

References 21 publications

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“…Among the remaining 88 articles, 10 were not concerned with G135C or G172T polymorphisms in RAD51gene, 7 were not human studies, 4 was not published in English, 6 were not case-control studies, 5 were no usable reported data, 2 were meeting abstracts, 4 were meta-analysis, and 11 were not in HWE; these publications were also excluded. Finally, a total of 54 case-control studies in 37 articles were identified in the current meta-analysis [16]–[54], among which 42 with 19142 cases and 20363 controls for RAD51 G135C polymorphism and 12 with 6646 cases and 6783 controls for G172T polymorphism. Genotype distributions in the controls of all selected studies are in agreement with HWE.…”

Section: Resultsmentioning

confidence: 99%

Relationship between Rad51 G135C and G172T Variants and the Susceptibility to Cancer: A Meta-Analysis Involving 54 Case-Control Studies

et al. 2014

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BackgroundThe associations between Rad51 gene polymorphisms (G135C and G172T) and risk of cancer have been investigated, but the results were inconclusive. To get a comprehensive evaluation of the association above, we performed a meta-analysis of published studies.MethodsA computerized search of PubMed, Embase and Web of Knowledge databases for all relevant studies was performed and the data were analyzed in a meta-analysis. The overall odds ratio (OR) with the 95% confidence interval (95% CI) was calculated to assess the strength of the association between Rad51 polymorphisms and cancer risk. Data were analyzed using fixed- or random-effects model when appropriate. Sensitivity analysis and publication bias test were also estimated.ResultsOverall, a total of 54 case-control studies were included in the current meta-analysis, among which 42 studies with 19,142 cases and 20,363 controls for RAD51 G135C polymorphism and 12 studies with 6,646 cases and 6,783 controls for G172T polymorphism. For G135C polymorphism, the pooled results indicated that significantly increased risk was found in overall cancers (homozygote model: OR = 1.776, 95% CI = 1.288–2.449; allelic genetic model: OR = 1.169, 95% CI = 1.016–1.345; recessive model: OR = 1.946, 95% CI = 1.336–2.835), especially in breast cancer (homozygote model: OR = 1.498, 95% CI = 1.026–2.189; recessive model: OR = 1.732, 95% CI = 1.170–2.562). For G172T polymorphism, a decreased cancer risk was observed in head and neck cancer (homozygote model: OR = 0.621, 95% CI = 0.460–0.837; allelic genetic model: OR = 0.824, 95% CI = 0.716–0.948; recessive model: OR = 0.639, 95% CI = 0.488–0.837).ConclusionsOur results suggested that the Rad51 G135C polymorphism is a candidate for susceptibility to overall cancers, especially to breast cancer, and that the Rad51 G172T might play a protective role in the development of head and neck cancer.

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Section: Resultsmentioning

confidence: 99%

Relationship between Rad51 G135C and G172T Variants and the Susceptibility to Cancer: A Meta-Analysis Involving 54 Case-Control Studies

et al. 2014

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“…Numerous studies confirm the significant role of the influence of specific genetic variants on repair phenotype and cancer risk [9][10][11][12][13][14][20][21][22].…”

Section: Discussionmentioning

confidence: 99%

“…RAD51 gene 135G>C and 172G>T polymorphism have been studied as a risk factor for various cancers such as breast, laryngeal, colorectal, and ovarian cancer [9][10][11][12][13][14]. However, results have been inconsistent.…”

Section: Introductionmentioning

confidence: 99%

Association between polymorphisms of the DNA repair gene RAD51 and ovarian cancer

Smolarz

Makowska²,

Samulak³

et al. 2013

pjp

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Genetic polymorphisms in the RAD51 gene may be associated with increased cancer risk. The aim of the present study was to evaluate associations between the risk of ovarian cancer and 135G>C (rs1801320) and 172G>T (rs1801321) polymorphisms in the RAD51 gene. We analysed the distribution of genotypes and frequency of alleles of the RAD51 polymorphisms in 210 women with ovarian cancer and 210 healthy controls. Both polymorphisms were genotyped by restriction fragment length polymorphism-polymerase chain reaction (PCR-RFLP). In the present study only 135G>C polymorphism of the RAD51 gene was associated with ovarian cancer risk. The distribution of genotypes for 135G>C in ovarian cancer patients vs. controls was: 20% vs. 30% for G/G, 22% vs. 47% for G/C, and 58% vs. 23% for C/C genotype, respectively. We found evidence of an increased ovarian cancer risk in C/C homozygotes but not in heterozygotes. The 135C allele of RAD51 increased cancer risk.In the present work we demonstrated a significant positive association between the RAD51 135G>C polymorphism and ovarian carcinoma in Poland. However, this gene requires further understanding of its interaction with other genes involved in tumour development.

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“…Two SNPs, G172 T and G135 C [14], have been identified in the 5 -untranslated region of RAD51; the RAD51 G135 C polymorphism has been associated with colorectal cancer, ovarian cancer, breast cancer, head and neck cancer, and others [15][16][17][18] in Polish populations. It has been proposed that a polymorphism in the 5 -untranslated region affects binding of regulatory elements that thus results in aberrant RAD51 protein function [19].…”

Section: Introductionmentioning

confidence: 99%

Genetic variants of the DNA damage repair genes XRCC4 and RAD51 are associated with susceptibility to esophageal cancer

Sun

Jin

et al. 2015

Clinics and Research in Hepatology and Gastroenterology

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RAD51 genotype and triple-negative breast cancer (TNBC) risk in Polish women

Cited by 23 publications

References 21 publications

Relationship between Rad51 G135C and G172T Variants and the Susceptibility to Cancer: A Meta-Analysis Involving 54 Case-Control Studies

Relationship between Rad51 G135C and G172T Variants and the Susceptibility to Cancer: A Meta-Analysis Involving 54 Case-Control Studies

Association between polymorphisms of the DNA repair gene RAD51 and ovarian cancer

Genetic variants of the DNA damage repair genes XRCC4 and RAD51 are associated with susceptibility to esophageal cancer

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