Racial Variation in Semen Quality at Fertility Evaluation

Khandwala, Yash S.; Zhang, Chiyuan A.; Li, Shufeng; Behr, Barry; Guo, David

doi:10.1016/j.urology.2017.03.064

Cited by 33 publications

(35 citation statements)

References 27 publications

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“…5 Subjects with post-testicular causes of infertility often show oligo-or azoospermia when a partial or a complete obstruction is present, respectively, 5,6 low semen volume and pH when ejaculatory duct obstruction or seminal vesicle/s agenesis/abnormalities occur, 5 and TV, gonadotropin and T levels in the normal range. 5 Large previous studies performed on infertile men reported that, according to the World Health Organization (WHO), 7 oligozoospermia was detected in 10% 8 to 30% [9][10][11] of cases, asthenozoospermia in 30%, 9,11 teratozoospermia in 21% 8 to 49%, 9 and low semen volume in 11% 11 to 15%. 8,10 Severe male factor infertility has been reported in 20.4% of infertile men, 2 azoospermia in ~ 5% 2,9 to 11%, 12 and T deficiency in 10.1 12 to 25.6% 13 of cases.…”

Section: Introductionmentioning

confidence: 97%

“…5 Large previous studies performed on infertile men reported that, according to the World Health Organization (WHO), 7 oligozoospermia was detected in 10% 8 to 30% [9][10][11] of cases, asthenozoospermia in 30%, 9,11 teratozoospermia in 21% 8 to 49%, 9 and low semen volume in 11% 11 to 15%. 8,10 Severe male factor infertility has been reported in 20.4% of infertile men, 2 azoospermia in ~ 5% 2,9 to 11%, 12 and T deficiency in 10.1 12 to 25.6% 13 of cases. On the other hand, large previous studies performed on fertile men reported lower rates of semen abnormalities compared with those of infertile men, showing oligozoospermia in ~ 3% 14,15 to 6% 16,17 of cases, asthenozoospermia in 10.4% 14 to 17%, 16 teratozoospermia in 2.5% 14 to ~ 10%, 15,16 and low semen volume in 4% 16 to 5.8%.…”

Section: Introductionmentioning

confidence: 97%

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The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: clinical, seminal and biochemical characteristics

et al. 2020

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Background Infertility affects 7%‐12% of men, and its etiology is unknown in half of cases. To fill this gap, use of the male genital tract color‐Doppler ultrasound (MGT‐CDUS) has progressively expanded. However, MGT‐CDUS still suffers from lack of standardization. Hence, the European Academy of Andrology (EAA) has promoted a multicenter study (“EAA ultrasound study”) to assess MGT‐CDUS characteristics of healthy, fertile men to obtain normative parameters. Objectives To report (a) the development and methodology of the “EAA ultrasound study,” (b) the clinical characteristics of the cohort of healthy, fertile men, and (c) the correlations of both fertility history and seminal features with clinical parameters. Methods A cohort of 248 healthy, fertile men (35.3 ± 5.9 years) was studied. All subjects were asked to undergo, within the same day, clinical, biochemical, and seminal evaluation and MGT‐CDUS before and after ejaculation. Results The clinical, seminal, and biochemical characteristics of the cohort have been reported here. The seminal characteristics were consistent with those reported by the WHO (2010) for the 50th and 5th centiles for fertile men. Normozoospermia was observed in 79.6% of men, while normal sperm vitality was present in almost the entire sample. Time to pregnancy (TTP) was 3.0[1.0‐6.0] months. TTP was negatively correlated with sperm vitality (Adj.r =−.310, P = .011), but not with other seminal, clinical, or biochemical parameters. Sperm vitality and normal morphology were positively associated with fT3 and fT4 levels, respectively (Adj.r = .244, P < .05 and Adj.r = .232, P = .002). Sperm concentration and total count were negatively associated with FSH levels and positively, along with progressive motility, with mean testis volume (TV). Mean TV was 20.4 ± 4.0 mL, and the lower reference values for right and left testes were 15.0 and 14.0 mL. Mean TV was negatively associated with gonadotropin levels and pulse pressure. Varicocoele was found in 33% of men. Conclusions The cohort studied confirms the WHO data for all semen parameters and represents a reference with which to assess MGT‐CDUS normative parameters.

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: clinical, seminal and biochemical characteristics

et al. 2020

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“…Une certitude apparait ici, la variabilité des paramètres des spermes en fonction des régions comme l'ont souligné El bardisi et al (2018). Cette différence serait due à l'exposition à des produits toxiques, comme l'ont souligné Dalvie et al (2004), des différences ethniques (Khandwala et al, 2017), sans oublier les habitudes et modes de vie tel que le tabagisme (Sharma et al, 2016).…”

Section: Discussionunclassified

Analyse des paramètres du spermogramme en relation avec le fructose, le citrate et l’alpha glucosidase neutre du sperme chez les hommes consultant pour infertilité à Libreville

Batou¹,

Abessolo²,

Immaculée³

et al. 2019

Int. J. Bio. Chem. Sci

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RESUME L'infertilité est un problème de santé publique dans les pays en voie de développement et son exploration onéreuse chez l'homme repose surtout sur la cytologie du sperme, sans l'associer à la biochimie du sperme. Ainsi une relation entre les anomalies du spermogramme et l'alpha-glucosidase, le fructose et le citrate du plasma séminal, a été rechercher, afin de justifier ou non la rareté de la biochimie du sperme. Une étude transversale et descriptive, s'est déroulée d'octobre 2017 à mars 2018 inclus, au laboratoire National de Santé Publique de Libreville. Tous les patients admis consécutivement pendant la période d'étude, pour effectuer un spermogramme pour bilan d'infertilité, ont été inclus. Le sperme, obtenu au laboratoire par masturbation, a servi aux analyses macroscopiques et microscopiques. L'alpha-glucosidase neutre, le fructose et le citrate ont été dosés dans le plasma séminal. L'analyse univariée a permis de choisir les paramètres à inclure dans l'analyse factorielle des correspondances entre les paramètres cytologiques et biochimiques. Sur le plan du spermogramme, les anomalies retrouvées étaient nombreuses et associées chez un même malade, eu égard à l'indice d'anomalies multiples. L'anomalie cytologique prédominante était l'oligoasthénotératonécrozoospermie (40,0%), suivie de l'oligoasthénotératospermie (7,3%). Sur le plan biochimique, l'apha-glucosidase était basse chez 21,8% des patients, alors que le citrate était abaissé chez 20,0% des sujets. Seuls 1,8% des sujets présentaient une baisse du taux de fructose. Par ailleurs, les anomalies biochimiques n'étaient pas associées aux anomalies du spermogramme. Le profil cytologique du spermogramme de cette population est dominé par les associations d'anomalies. Cependant, comme ces paramètres ne sont pas associés aux paramètres biochimiques du plasma séminal, il est indispensable de prescrire ces deux types d'analyses pour une meilleure prise en charge des sujets consultant pour infertilité.

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“…In the past few decades, numerous studies have presented indications of a time‐based decline in semen quality from different parts of the world (Auger, Kunstmann, Czyglik, & Jouannet, ; Carlsen, Giwercman, Keiding, & Skakkebaek, ; Rolland, Le Moal, Wagner, Royere, & De Mouzon, ). The findings of these studies seem to differ down to the geographical locations of the representative male populations (Khandwala et al, ; Paulsen, Berman, & Wang, ).…”

Section: Introductionmentioning

confidence: 99%

Geographical differences in semen characteristics: Comparing semen parameters of infertile men of the United States and Iraq

et al. 2020

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The declining trend of male fecundity is a major global health and social concern. Among numerous other confounding factors, variations in male fertility parameters in different regions have repeatedly been suggested to be influenced by geographic locations. The impact of overall lifestyle, behavioural patterns, ethnicity, work stress and associated factors upon health differ greatly between developed and developing countries. These factors, individually or in combination, affect male reproductive functions ensuing the discrepancies in semen qualities in connection with geographic variations. However, reports comparing semen characteristics between developed and developing countries are sparse. The present study finds its novelty in presenting a comparison in semen parameters of infertile men in the United States (n = 76) that fairly represents the population of a highly developed region and Iraq (n = 102), the representative of male populations of a developing region. Samples were collected and analysed according to WHO (WHO laboratory manual for the examination and processing of human semen, WHO; 2010) criteria by means of the Mann–Whitney test. The US population demonstrated lower sperm concentration, total count, and total and progressive sperm motility with a higher seminal total antioxidant capacity (TAC) as compared to the Iraqi population. This report encourages further investigations concerning the confounding factors leading to such alterations in semen qualities between these two geographic areas.

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Racial Variation in Semen Quality at Fertility Evaluation

Cited by 33 publications

References 27 publications

The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: clinical, seminal and biochemical characteristics

The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: clinical, seminal and biochemical characteristics

Analyse des paramètres du spermogramme en relation avec le fructose, le citrate et l’alpha glucosidase neutre du sperme chez les hommes consultant pour infertilité à Libreville

Geographical differences in semen characteristics: Comparing semen parameters of infertile men of the United States and Iraq

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