Racial differences in disease phenotypes in patients with Crohnʼs disease

Cross, Raymond K.; Jung, Carrianne; Wasan, Sharmeel K.; Joshi, Grishma; Sawyer, Robert B.; Roghmann, Mary-Claire

doi:10.1097/01.mib.0000217767.98389.20

Cited by 50 publications

(38 citation statements)

References 26 publications

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“…12,38,41 In the Cross et al 41 study, 73% of the Caucasian participants were diagnosed after the age of 40 (A3). Deveaux et al 12 and Simsek and Schuman 38 also reported that the majority of patients were diagnosed between the ages of 17 and 40 (A2) in both racial groups (Table 3).…”

Section: Crohn's Disease: Age Of Onsetmentioning

confidence: 98%

Inflammatory bowel disease and African Americans: A systematic review

Mahid

Mulhall

Gholson

et al. 2008

Inflammatory Bowel Diseases

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Section: Crohn's Disease: Age Of Onsetmentioning

confidence: 98%

Inflammatory bowel disease and African Americans: A systematic review

Mahid

Mulhall

Gholson

et al. 2008

Inflammatory Bowel Diseases

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“…7 Since then, numerous other studies examining CD in AA patients using institutional registries also showed no difference in disease severity between AA and non-AA patients. 2,4,8 The question that must then be asked is whether AA patients are receiving lower quality medical management of CD, which predisposes them to non-ideal circumstances at the time of surgical resection. While Nguyen did not show a difference in overall immunosuppressive medication use between AA and white patients, there was a significant decrease among AA patients in the use of infliximab, a targeted biological therapy.…”

Section: Discussionmentioning

confidence: 99%

African Americans and Short-Term Outcomes after Surgery for Crohn’s Disease: An ACS-NSQIP Analysis

Arsoniadis

Melton

et al. 2016

ECCOJC

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Background: Previous reports on racial disparities in the treatment of Crohn's disease [CD] [smoking], race remained a statistically significant factor in postoperative complication rate. Only after additional adjustment was made for comorbidities and American Society of Anesthesiologists class did race lose significance within our model. Conclusion: African Americans experience a greater amount of postoperative complications following surgery for Crohn's disease. Preoperative disease management, addressing smoking status and control of comorbid disease are important factors in addressing the racial disparities in the surgical treatment of Crohn's disease.

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“…Previous studies indicated substantial racial/ethnic differences in the characteristics of IBD in the United States and worldwide [1,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24]. Little data exists with regard to the prevalence of IBD in Blacks in the United States and in Asians outside Asia [23].…”

Section: Introductionmentioning

confidence: 99%

“…Little data exists with regard to the prevalence of IBD in Blacks in the United States and in Asians outside Asia [23]. There were conflicting findings on whether racial/ethnic groups differ in the distribution and behavior of IBD, with some (but not all) studies showing a more aggressive disease phenotype and worse outcomes without adequate control for risk factors including socioeconomic status [12,13,15,16,17,18,19,21,23]. In addition, significant regional differences were reported in the prevalence of IBD, with it being more frequent in the northern parts of the United States [1,5,25].…”

Section: Introductionmentioning

confidence: 99%

Racial/Ethnic and Regional Differences in the Prevalence of Inflammatory Bowel Disease in the United States

Wang

Loftus²,

Cangemi

et al. 2013

Digestion

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Background: The magnitude of racial/ethnic and regional differences in the prevalence of inflammatory bowel disease (IBD) in the United States remains largely unknown. Aims: To estimate differences in the prevalence of IBD by race/ethnicity and region. Methods: The Medical Expenditure Panel Survey, a nationally representative survey of US households and medical conditions, was used. A multivariate logistic model was used in statistical analysis. Results: Among 202,468 individuals surveyed during 1996-2007, 316 were diagnosed with IBD (26 Blacks, 21 Hispanics, and 5 Asians). The prevalence of IBD was higher in Whites [Crohn's disease: 154; ulcerative colitis (UC): 89] than Blacks (Crohn's disease: 68; UC: 25), Hispanics (Crohn's disease: 15; UC: 35), and Asians (Crohn's: 45; UC: 40) (all p < 0.05, except for UC in Asians). The differences in Crohn's disease between Whites and minorities and the difference in UC between Whites and Blacks remained significant in multivariate analysis. In multivariate analysis, there was no regional difference in the prevalence of Crohn's disease, but the prevalence of UC was higher in the Northeast than the South (p < 0.05). Conclusions: There were significant racial/ethnic differences in the prevalence of IBD in the USA. The underlying etiology of these differences warrants additional research.

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Racial differences in disease phenotypes in patients with Crohnʼs disease

Abstract: We did not detect differences in disease behavior, severity, or joint EIM by race. Although African American patients were more likely to have ileocolonic or colonic disease, these factors did not affect disease behavior or severity.

Cited by 50 publications

References 26 publications

Inflammatory bowel disease and African Americans: A systematic review

Inflammatory bowel disease and African Americans: A systematic review

African Americans and Short-Term Outcomes after Surgery for Crohn’s Disease: An ACS-NSQIP Analysis

Racial/Ethnic and Regional Differences in the Prevalence of Inflammatory Bowel Disease in the United States

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