Race to invade: Understanding soft tissue integration at the transmucosal region of titanium dental implants

Guo, Tianqi; Gulati, Karan; Arora, Himanshu; Han, Pingping; Fournier, Benjamin; Ivanovski, Sašo

doi:10.1016/j.dental.2021.02.005

Cited by 93 publications

(80 citation statements)

References 105 publications

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“…In the case of transmucosal and percutaneous dental or orthopedic implants, an effective soft tissue sealing around the implant is crucial for good functionality and prevention of bacterial infiltration [24], in addition to bone integration. Even if surface modifications for soft tissue contact are less explored than the ones for bone integration, some research works investigate the possibility of topographical, chemical or biological modifications able to guide soft tissue onto titanium surfaces [25].…”

Section: Introductionmentioning

confidence: 99%

Contact Guidance Effect and Prevention of Microfouling on a Beta Titanium Alloy Surface Structured by Electron-Beam Technology

et al. 2021

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Nano- and micro-structuring of implantable materials constitute a promising approach to introduce mechanical contact guidance effect, drive cells colonization, as well as to prevent bacteria adhesion and biofilm aggregation, through antifouling topography. Accordingly, this paper aims to extend the application of e-beam surface texturing and nano-structuring to the beta titanium alloys, which are of great interest for biomedical implants because of the low Young modulus and the reduction of the stress shielding effect. The paper shows that surface texturing on the micro-scale (micro-grooves) is functional to a contact guidance effect on gingival fibroblasts. Moreover, nano-structuring, derived from the e-beam surface treatment, is effective to prevent microfouling. In fact, human fibroblasts were cultivated directly onto grooved specimens showing to sense the surface micro-structure thus spreading following the grooves’ orientation. Moreover, Staphylococcus aureus colonies adhesion was prevented by the nano-topographies in comparison to the mirror-polished control, thus demonstrating promising antifouling properties. Furthermore, the research goes into detail to understand the mechanism of microfouling prevention due to nano-topography and microstructure.

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Section: Introductionmentioning

confidence: 99%

Contact Guidance Effect and Prevention of Microfouling on a Beta Titanium Alloy Surface Structured by Electron-Beam Technology

et al. 2021

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“…The local release of therapeutics from TNTs has been widely explored towards optimizing the loading and local elution of potent antibacterial agents [30]. It is noteworthy that within minutes of implantation, saliva proteins adhere to the dental implant, forming a pellicle, and early colonizers such as Streptococci adhere to these pellicles within 48h [66]. This can be followed by secondary colonizers, including Fusobacterium nucleatum, Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis [67].…”

Section: Antibacterial Functionsmentioning

confidence: 99%

“…When a drug-releasing implant is placed, several cells 'race to invade' the site [66], and often the nanotopography is immediately covered with proteins and cells, which may block the open pores [117,212]. This can impact drug release, given that the latter is dependent on a diffusion gradient that is impeded by poor perfusion inside the bone micro-environment.…”

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confidence: 99%

Dental Implant Nano-Engineering: Advances, Limitations and Future Directions

Zhang

Gulati

et al. 2021

Nanomaterials

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Titanium (Ti) and its alloys offer favorable biocompatibility, mechanical properties and corrosion resistance, which makes them an ideal material choice for dental implants. However, the long-term success of Ti-based dental implants may be challenged due to implant-related infections and inadequate osseointegration. With the development of nanotechnology, nanoscale modifications and the application of nanomaterials have become key areas of focus for research on dental implants. Surface modifications and the use of various coatings, as well as the development of the controlled release of antibiotics or proteins, have improved the osseointegration and soft-tissue integration of dental implants, as well as their antibacterial and immunomodulatory functions. This review introduces recent nano-engineering technologies and materials used in topographical modifications and surface coatings of Ti-based dental implants. These advances are discussed and detailed, including an evaluation of the evidence of their biocompatibility, toxicity, antimicrobial activities and in-vivo performances. The comparison between these attempts at nano-engineering reveals that there are still research gaps that must be addressed towards their clinical translation. For instance, customized three-dimensional printing technology and stimuli-responsive, multi-functional and time-programmable implant surfaces holds great promise to advance this field. Furthermore, long-term in vivo studies under physiological conditions are required to ensure the clinical application of nanomaterial-modified dental implants.

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“…Further, Zr and its alloys are extensively used in the field of optics, magnetics, chemical sensors, and biomedical implants [2]. Due to their favourable characteristics (physical, chemical, and biological), Zr-based implants are gaining popularity in the dental and orthopaedic markets [3,4]. For this application, the favourable biocompatibility of Zr is mainly attributed to its surface oxide film (ZrO 2 ).…”

Section: Introductionmentioning

confidence: 99%

Towards Clinical Translation: Optimized Fabrication of Controlled Nanostructures on Implant-Relevant Curved Zirconium Surfaces

2021

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Anodization enables fabrication of controlled nanotopographies on Ti implants to offer tailorable bioactivity and local therapy. However, anodization of Zr implants to fabricate ZrO2 nanostructures remains underexplored and are limited to the modification of easy-to-manage flat Zr foils, which do not represent the shape of clinically used implants. In this pioneering study, we report extensive optimization of various nanostructures on implant-relevant micro-rough Zr curved surfaces, bringing this technology closer to clinical translation. Further, we explore the use of sonication to remove the top nanoporous layer to reveal the underlying nanotubes. Nano-engineered Zr surfaces can be applied towards enhancing the bioactivity and therapeutic potential of conventional Zr-based implants.

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Race to invade: Understanding soft tissue integration at the transmucosal region of titanium dental implants

Cited by 93 publications

References 105 publications

Contact Guidance Effect and Prevention of Microfouling on a Beta Titanium Alloy Surface Structured by Electron-Beam Technology

Contact Guidance Effect and Prevention of Microfouling on a Beta Titanium Alloy Surface Structured by Electron-Beam Technology

Dental Implant Nano-Engineering: Advances, Limitations and Future Directions

Towards Clinical Translation: Optimized Fabrication of Controlled Nanostructures on Implant-Relevant Curved Zirconium Surfaces

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