Race/ethnicity-based temporal changes in prevalence of NAFLD-related advanced fibrosis in the United States, 2005–2016

Kim, Dong‐Hee; Kim, Won; Adejumo, Adeyinka Charles; Cholankeril, George; Tighe, Sean; Wong, Robert J.; Gonzalez, Stevan A.; Harrison, Stephen A.; Younossi, Zobair M.; Ahmed, Aijaz

doi:10.1007/s12072-018-09926-z

Cited by 66 publications

(75 citation statements)

References 25 publications

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“…3,19 The NHANES database included a detailed questionnaire which covered demographic and lifestyle information including depression and physical activity, anthropometric measures, and a comprehensive laboratory examination. 3,19 The NHANES database included a detailed questionnaire which covered demographic and lifestyle information including depression and physical activity, anthropometric measures, and a comprehensive laboratory examination.…”

Section: Clinical and Laboratory Evaluationsmentioning

confidence: 99%

“…3 Briefly, we defined NAFLD using the US Fatty Liver Index (USFLI), Hepatic Steatosis Index (HSI) and Fatty Liver Index (FLI) in the absence of other causes of chronic liver disease and use of steatogenic medication. 3 Briefly, we defined NAFLD using the US Fatty Liver Index (USFLI), Hepatic Steatosis Index (HSI) and Fatty Liver Index (FLI) in the absence of other causes of chronic liver disease and use of steatogenic medication.…”

Section: Definition Of Nafld and Advanced Fibrosismentioning

confidence: 99%

“…1,2 Not surprisingly, a recent study showed that NAFLD-related advanced fibrosis is on the rise at an accelerated pace in American adults, 3 which may result in increased overall mortality and cause-specific death. 1,2 Not surprisingly, a recent study showed that NAFLD-related advanced fibrosis is on the rise at an accelerated pace in American adults, 3 which may result in increased overall mortality and cause-specific death.…”

Section: Introductionmentioning

confidence: 99%

“…Currently, non-alcoholic fatty liver disease (NAFLD) is recognised as the most prevalent chronic liver disease in the United States (US) and the world. 1,2 Not surprisingly, a recent study showed that NAFLD-related advanced fibrosis is on the rise at an accelerated pace in American adults, 3 which may result in increased overall mortality and cause-specific death. 4,5 Another study based on a national US mortality database reported an increase in mortality rate from NAFLD from an annual rate of 6.1% in 2007-2013 to 11.3% in 2013-2016.…”

Section: Introductionmentioning

confidence: 99%

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Depression is associated with non‐alcoholic fatty liver disease among adults in the United States

Kim

Yoo

et al. 2019

Aliment Pharmacol Ther

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Background: Currently, the relationship between depression and non-alcoholic fatty liver disease (NAFLD) is not clearly defined. Aim:To determine whether depression is associated with NAFLD and NAFLD-related advanced fibrosis in a large population sample. Methods: We performed a cross-sectional analysis using the 2007-2016 National Health and Nutrition Examination Survey database among adults (20 years or older) in the United States (US). Depression and functional impairment due to depression were assessed with the Patient Health Questionnaire (PHQ-9). NAFLD was defined by utilising the US fatty liver index (USFLI), hepatic steatosis index (HSI) and the fatty liver index (FLI) in the absence of other causes of chronic liver disease. The presence and absence of advanced fibrosis in NAFLD were defined by Fibrosis-4 score.Results: Of the 10 484 subjects (mean age 47.0 years; 48.8% men), the prevalence of depression and functional impairment due to depression was higher in subjects with NAFLD than in those without. Compared to subjects without depression, those with depression were 1.6-2.2-fold more likely to have NAFLD. In our multivariate analyses, depression_med was associated with increased risk of NAFLD using USFLI (odds ratio [OR] 1.48 95% confidence interval [CI] 1.17-1.87), HSI (OR 1.51 95% CI 1.04-2.19) and FLI (OR 2.01 95% CI 1.65-2.48), respectively. The addition of diabetes, obesity and lipid profile to the model reduced the ORs for depression, but the significance persisted. Depression was not associated with NAFLD-related advanced fibrosis. Conclusions:In a nationally representative sample of US adults, depression was independently associated with NAFLD. | 591KIM et al.

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Section: Clinical and Laboratory Evaluationsmentioning

confidence: 99%

Section: Definition Of Nafld and Advanced Fibrosismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Depression is associated with non‐alcoholic fatty liver disease among adults in the United States

Kim

Yoo

et al. 2019

Aliment Pharmacol Ther

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“…5 In the United States, NAFLD has become the third most common cause of hepatocellular carcinoma (HCC), with an estimated increments of 9% on an annual basis. 8,9 Not surprisingly, NAFLD-related advanced fibrosis is on the rise at an accelerated pace in American adults, 10 which translates to an increase in overall and cause-specific mortality. 11,12 A study using the national US mortality database reported an increase in the mortality of NAFLD from an annual rate of 6.1% in 2007-2013 to 11.3% in 2013-2016.…”

Section: Introductionmentioning

confidence: 99%

Diet quality and its association with nonalcoholic fatty liver disease and all‐cause and cause‐specific mortality

Yoo

Kim

Vazquez‐Montesino

et al. 2020

Liver International

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Background & Aims Healthy diet has been recommended for nonalcoholic fatty liver disease (NAFLD), although it is not clear whether improving diet quality can prevent mortality. We aim to assess the impact of quality of diet on NAFLD and mortality in subjects with and without NAFLD. Methods We performed cohort study using the Third National Health and Nutrition Examination Survey from 1988 to 1994 and linked mortality data through 2015. We used the Healthy Eating Index (HEI) scores to define diet quality, with higher HEI scores (Q4) indicating better adherence to dietary recommendations. NAFLD was defined as ultrasonographic hepatic steatosis. Results Multivariate analysis showed that subjects with higher diet quality were inversely associated with NAFLD in a dose‐dependent manner. During the median follow‐up of 23 years, having a higher diet quality was associated with reduction in risk of all‐cause mortality in the age, sex, Race/ethnicity‐adjusted hazard ratio (HR) (Q4, HR: 0.60, 95% CI: 0.52‐0.68) and the multivariate model (Q4, HR: 0.81, 95% CI: 0.71‐0.92). Higher diet quality was associated with a lower risk for all‐cause mortality in subjects without NAFLD; however, this protective association with diet quality was not noted in those with NAFLD. Furthermore, a high diet quality was associated with a lower risk for cancer‐related mortality in the total population and among those without NAFLD. This association was not noted in those with NAFLD. Conclusions High diet quality was inversely associated with NAFLD and was positively associated with a lower risk for cancer‐related and all‐cause mortality in those without NAFLD.

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Association Between Psoriasis and Nonalcoholic Fatty Liver Disease Among Outpatient US Adults

Ruan

Chen

et al. 2022

JAMA Dermatol

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IMPORTANCE Recent studies have shown an association between psoriasis and nonalcoholic fatty liver disease (NAFLD) in US inpatients, but the association is still unclear in the outpatient US population. OBJECTIVE To assess whether psoriasis is associated with NAFLD in outpatient US adults. DESIGN, SETTING, AND PARTICIPANTS This population-based cross-sectional study used data on US adults aged 20 to 59 years from the National Health and Nutrition Examination Survey (NHANES) 2003-2006 and 2009-2014 cycles. Data were analyzed from June to September 2021.EXPOSURES Self-reported psoriasis. MAIN OUTCOMES AND MEASURESThe main outcome was NAFLD, defined as a US fatty liver index score greater than 30. Sampling weights were calculated according to NHANES guidelines. RESULTS Among 5672 adults included in this study (mean age, 38.9 years [95% CI,; 2999 [51.1%] female), 148 (3.0%) had psoriasis and 5524 (97.0%) did not have psoriasis. A total of 1558 participants (26.8%) were classified as having NAFLD. Compared with participants without psoriasis, those with psoriasis had a higher prevalence of NAFLD (32.7% [52] vs 26.6% [1506]). In a multivariable logistic regression model adjusted for age, sex, race and ethnicity, educational level, family income, marital status, NHANES cycles, diabetes, metabolic syndrome, and smoking and alcohol drinking status, psoriasis was associated with NAFLD (odds ratio [OR], 1.67; 95% CI, 1.03-2.70). In subgroup analyses, psoriasis was associated with NAFLD among men (OR, 2.16; 95% CI, 1.10-4.24), among those aged 20 to 39 years (OR, 2.48; 95% CI, 1.09-5.67), and among those without diabetes (1.70; 95% CI, 1. 05-2.76). An association between psoriasis and NAFLD was found in sensitivity analyses that excluded potential hepatotoxic medication use (OR, 1.72; 95% CI, 1.01-2.95) or non-Hispanic Black participants (OR, 1.76; 95% CI, 1.07-2.87), redefined NAFLD based on the hepatic steatosis index score (OR, 1.59; 95% CI, 1.01-2.50), and used inverse probability of treatment weighting (OR, 1.43; 95% CI, 1.09-1.86). CONCLUSIONS AND RELEVANCEIn this cross-sectional study, psoriasis was associated with NAFLD in the outpatient US adult population in adjusted models. This association may be important to consider in the context of clinicians prescribing potentially hepatotoxic medication for psoriasis management.

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Race/ethnicity-based temporal changes in prevalence of NAFLD-related advanced fibrosis in the United States, 2005–2016

Cited by 66 publications

References 25 publications

Depression is associated with non‐alcoholic fatty liver disease among adults in the United States

Depression is associated with non‐alcoholic fatty liver disease among adults in the United States

Diet quality and its association with nonalcoholic fatty liver disease and all‐cause and cause‐specific mortality

Association Between Psoriasis and Nonalcoholic Fatty Liver Disease Among Outpatient US Adults

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