Race, age, and sex differences on the influence of obesity on colorectal cancer sidedness and mortality: A national cross‐sectional study

Abstract

Background and Objectives: Colorectal cancer (CRC) sidedness is recognized as a prognostic factor for survival; left-sided colorectal cancer is associated with better outcomes than right-sided colon cancer (RsCC). We aimed to evaluate the influence of obesity on CRC sidedness and determine how race, age, and sex affect mortality among overweight and obese individuals.Methods: A survey-weighted analysis was conducted using data obtained from the National Inpatient Sample between 2016 and 2019.Results: Of the 24 549 patients with a diagnosis of CRC and a reported body mass index (BMI), 13.6% were overweight and 49.9% were obese. The race distribution was predominantly non-Hispanic Whites (69.7%), followed by Black (15.6%), Hispanic (8.7%), and other race (6.1%). Overweight (BMI: 25−29.9) and obese (BMI: ≥30) individuals were more likely to have RsCC

Colorectal cancer statistics, 2023

“…These differences accounted for 25% and 32% of the Black–White survival disparity for colon cancer and rectal cancer, respectively. Although higher mortality in Black individuals has been attributed in part to the disproportionate development of right‐sided tumors, 121 which are associated with lower survival, 91 cancer registry data covering 99% of the population indicate that the distribution is similar (41%) to that of White individuals (40%), consistent with contemporary literature 123,124 …”

“…Although higher mortality in Black individuals has been attributed in part to the disproportionate development of right-sided tumors, 121 which are associated with lower survival, 91 cancer registry data covering 99% of the population indicate that the distribution is similar (41%) to that of White individuals (40%), consistent with contemporary literature. 123,124 The racial disparity in CRC mortality has slowly narrowed since 2005, when rates were almost 50% higher in Black individuals, to 33% in 2020 because the rapid declines of the 2000s have slowed in White individuals but persisted in Black individuals (Table 4). Among…”

Sex-related differences in oncologic outcomes, operative complications and health-related quality of life after curative-intent oesophageal cancer treatment: multicentre retrospective analysis

“…In the present analysis, the predominant SCC subtype in females is thought to account for the better histologic response to neoadjuvant treatment, as no sex-related differences in ypTNM or TRG were observed within separate histological subtypes. As the baseline differences in cN0 stage and treatment modalities were adjusted for in all multivariable analyses, inherent biologic differences may also be suggested to explain outcome differences between male and female patients with OC, as previously described in gastric 7 and colon cancer 9 . Indeed, oestrogen receptor β (ERβ) is strongly expressed on the nucleus of oesophageal AC cells 28 , 29 .…”

“…Sex-related differences have previously been described in gastric and colorectal cancer for instance, where an obvious link between hormonal drive and tumour progression is not known to exist 7 , 9 . Such results have also been described for OC, where male patients were reported to have poorer long-term survival after surgery 3 , 6 , 10 .…”