Rabies virus glycoprotein and immune response pattern using recombinant protein or recombinant RNA viral vectors

Astray, Renato Mancini; Ventini, Daniella C.; Boldorini, Vera Lucia Lopes; Silva, Fernanda Gonçalves; Rocca, Márcia A.; Pereira, Carlos Augusto

doi:10.1016/j.vaccine.2014.02.029

Cited by 14 publications

(11 citation statements)

References 16 publications

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“…Vaccines delivering nucleic acids often aim to promote the transient expression of the cargo encoded protein with immunostimulatory properties. Immunogens are often encoded to promote antigen presentation via MHC-I [64]. Nevertheless these nucleic acids can also induce the expression of an immunomodulatory protein as IL10 [65], or block immunosupressor pathways with the delivery of small interfering RNA (siRNA) [66].…”

Section: Vectored Vaccinesmentioning

confidence: 99%

Viral vaccines and their manufacturing cell substrates: New trends and designs in modern vaccinology

Rodrigues

Soares

Guerreiro

et al. 2015

Biotechnology Journal

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Vaccination is one of the most effective interventions in global health. The worldwide vaccination programs significantly reduced the number of deaths caused by infectious agents. A successful example was the eradication of smallpox in 1979 after two centuries of vaccination campaigns. Since the first variolation administrations until today, the knowledge on immunology has increased substantially. This knowledge combined with the introduction of cell culture and DNA recombinant technologies revolutionized vaccine design. This review will focus on vaccines against human viral pathogens, recent developments on vaccine design and cell substrates used for their manufacture. While the production of attenuated and inactivated vaccines requires the use of the respective permissible cell substrates, the production of recombinant antigens, virus-like particles, vectored vaccines and chimeric vaccines requires the use - and often the development - of specific cell lines. Indeed, the development of novel modern viral vaccine designs combined with, the stringent safety requirements for manufacture, and the better understanding on animal cell metabolism and physiology are increasing the awareness on the importance of cell line development and engineering areas. A new era of modern vaccinology is arriving, offering an extensive toolbox to materialize novel and creative ideas in vaccine design and its manufacture.

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Section: Vectored Vaccinesmentioning

confidence: 99%

Viral vaccines and their manufacturing cell substrates: New trends and designs in modern vaccinology

Rodrigues

Soares

Guerreiro

et al. 2015

Biotechnology Journal

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show abstract

“…In the case of self-amplifying mRNA-based rabies vaccines, it was shown that a recombinant SFV, carrying an RNA coding RABV G protein (SFV-RVGP), induced high expression levels of functionally trimeric RABV G protein [118]. Moreover, SFV-RVGP elicited comparable levels of antibodies to that of a commercial rabies vaccine, and was more effective than the protein vaccines in inducing a cellular immune response [119]. …”

Section: Other Novel Modalities For Rabies Control and Preventionmentioning

confidence: 99%

Rabies Control and Treatment: From Prophylaxis to Strategies with Curative Potential

Zhu

Guo

2016

Viruses

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Rabies is an acute, fatal, neurological disease that affects almost all kinds of mammals. Vaccination (using an inactivated rabies vaccine), combined with administration of rabies immune globulin, is the only approved, effective method for post-exposure prophylaxis against rabies in humans. In the search for novel rabies control and treatment strategies, live-attenuated viruses have recently emerged as a practical and promising approach for immunizing and controlling rabies. Unlike the conventional, inactivated rabies vaccine, live-attenuated viruses are genetically modified viruses that are able to replicate in an inoculated recipient without causing adverse effects, while still eliciting robust and effective immune responses against rabies virus infection. A number of viruses with an intrinsic capacity that could be used as putative candidates for live-attenuated rabies vaccine have been intensively evaluated for therapeutic purposes. Additional novel strategies, such as a monoclonal antibody-based approach, nucleic acid-based vaccines, or small interfering RNAs (siRNAs) interfering with virus replication, could further add to the arena of strategies to combat rabies. In this review, we highlight current advances in rabies therapy and discuss the role that they might have in the future of rabies treatment. Given the pronounced and complex impact of rabies on a patient, a combination of these novel modalities has the potential to achieve maximal anti-rabies efficacy, or may even have promising curative effects in the future. However, several hurdles regarding clinical safety considerations and public awareness should be overcome before these approaches can ultimately become clinically relevant therapies.

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“…Nas pesquisas realizadas com proteína recombinante vale ressaltar que, em todas as pesquisas onde foram realizados testes desafio (inoculação do vírus da raiva nos animais previamente imunizados), somente os animais imunizados com proteínas sintetizadas por células de animais mostraram sobrevivência superior a 50% (AMANN et al, 2013;ASTRAY et al, 2014;CENNA et al, 2008;ERTL et al, 1989;FU et al, 1991;GUPTA et al, 2005;HU et al, 2007;KLEPFER et al, 1993;KORAKA et al, 2014;LECOCQ et al, 1985;NIEDERHÄUSER et al, 2008;ROJAS-ANAYA et al, 2009;TUCHIYA et al, 1992;WANG et al, 2012;WIKTOR et al, 1984;WU et al, 2014;XIANG et al, 2014).…”

Section: A Raiva a Vacina Contra Raiva E O Panorama Mundialunclassified

Purificação e imunogenicidade da glicoproteína do vírus da raiva (RVGP) expressa pelos sistemas células S2 e Semliki Forest Virus.

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Rabies virus glycoprotein and immune response pattern using recombinant protein or recombinant RNA viral vectors

Cited by 14 publications

References 16 publications

Viral vaccines and their manufacturing cell substrates: New trends and designs in modern vaccinology

Viral vaccines and their manufacturing cell substrates: New trends and designs in modern vaccinology

Rabies Control and Treatment: From Prophylaxis to Strategies with Curative Potential

Purificação e imunogenicidade da glicoproteína do vírus da raiva (RVGP) expressa pelos sistemas células S2 e Semliki Forest Virus.

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