Rabies vaccination inducing eruptive lichen planus in a child

Bhanja, Dibyendu Bikash; Sil, Abheek; Das, Amitava; Panigrahi, Avik; Biswas, Surajit Kumar

doi:10.1111/ced.14396

Cited by 5 publications

(6 citation statements)

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“…The subepithelial connective tissue stroma showed inflammatory cell infiltrate, chiefly lymphocytes and “sawtooth” rete ridges, which are peculiar for the diagnosis of LP 13,17 . In the case of erosive and atrophic LP, atrophic parakeratinized stratified squamous epithelium with sawtooth rete pegs and subepithelial evidence of well‐defined band of chronic inflammatory cells predominantly lymphocytes were seen 14,23 …”

Section: Resultsmentioning

confidence: 99%

“…Lesions involving both skin and oral mucosa were seen in 23.52% (20/85) of patients, which was in agreement with other studies mentioning a range of 13.7-30%. 14,37 Propensity for multiple intraoral sites was observed in most of the oral lesions with predominant occurrence on the tongue and the buccal mucosa in 24 out of total 26 oral cases (92.30%) (Table 2). Comparable results were also reported by Axell et al 38 in their studies on LP in the adult population (buccal mucosa 92% and tongue 28%).…”

Section: Discussionmentioning

confidence: 99%

“…13,17 Resolution was observed in 2-4 weeks reported in eight cases from seven studies. 2,14,17,19,23,32 In the 2-month follow-up period, the cutaneous lesions resolved with residual hyperpigmentation, and a 6-month follow-up of the white lesions showed a decrease in severity. 2…”

Section: History Of Vaccinationmentioning

confidence: 98%

“…13,17 In the case of erosive and atrophic LP, atrophic parakeratinized stratified squamous epithelium with sawtooth rete pegs and subepithelial evidence of well-defined band of chronic inflammatory cells predominantly lymphocytes were seen. 14,23 Treatment…”

Section: History Of Vaccinationmentioning

confidence: 99%

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Association of childhood vaccination with pediatric lichen planus: A systematic review

et al. 2021

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Lichen planus (LP) is a chronic T-cell-mediated mucocutaneous inflammatory disease, largely recognized in adults. It is uncommon in children, and the literature present still lacks comprehensive understanding mainly due to underreporting of such cases. LP shows atypical clinical features, when seen in children, mainly affecting the flexor aspect of the wrists, legs, and the oral and genital mucosae. It is largely considered an autoimmune response of the body with various etiologic factors. Its association with vaccination is still an interesting field for research. The focus of the present systematic review was to discover the link of vaccine in the pathogenesis of juvenile LP. An electronic search was carried out using MEDLINE by PubMed, Google Scholar, and Web of Science databases.Articles that reported LP in children with prior records for vaccination were selected for the present systematic review. Twenty-three published articles in the English language were included for the quantitative and qualitative syntheses. The demographic data, specific vaccine history, and clinical details of the lesions were recorded. The existing evidence supports that vaccines could play an important role in etiopathogenesis of pediatric LP.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: History Of Vaccinationmentioning

confidence: 98%

Section: History Of Vaccinationmentioning

confidence: 99%

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Association of childhood vaccination with pediatric lichen planus: A systematic review

et al. 2021

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“…Exanthematous or eruptive lichen planus (ELP) is a distinctive variant of lichen planus (LP) that accounts for about 5.3–7% of paediatric LP patients 1 . Although the exact cause remains unknown, cytotoxic T‐cell activation by viral infection (hepatitis C, hepatitis B), drugs (beta‐blockers, methyldopa) and vaccination (against hepatitis B, rabies, influenza) has been postulated to play a role in the pathogenesis 2 . A significant association between specific HLA antigens (HLA‐B27, HLA‐B51) and LP has been established.…”

Section: Answermentioning

confidence: 99%