Rabbit plasma metabolomic analysis of Nitroproston®: a multi target natural prostaglandin based-drug

Shestakova, Ksenia; Brito, Alex; Mesonzhnik, Natalia V.; Moskaleva, Natalia E.; Kurynina, Ksenia O; Grestskaya, Natalia M; Серков, И. В.; Lyubimov, Igor I; Безуглов, В. В.; Appolonova, Svetlana A.

doi:10.1007/s11306-018-1413-1

Cited by 5 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…15 We assigned the most likely chemical class to be a saturated oxo-fatty acid (SOFA), which comprised seven of the 149 chemical structures identified in the CompTox Chemicals Dashboard search. SOFAs are involved in fatty acid biosynthesis pathways in all eukaryotes, contain a carboxylic acid group for negative mode ionization, and have been documented in bacteria, 16 yeast, 17 human breath, 18 human plasma, 19 rabbit plasma, 20 and cows and goats milk. 21 Of the several potential dodecanoic SOFAs with the assigned formula C 12 H 22 O 3 , we hypothesize that 3-oxododecanoic acid (Figure 2) is the major chemical interferent observed in the placenta samples, with the interfering 213 → 169 transition occurring as a minor, secondary fragment (Figure 2).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…We assigned the most likely chemical class to be a saturated oxo-fatty acid (SOFA), which comprised seven of the 149 chemical structures identified in the CompTox Chemicals Dashboard search. SOFAs are involved in fatty acid biosynthesis pathways in all eukaryotes, contain a carboxylic acid group for negative mode ionization, and have been documented in bacteria, yeast, human breath, human plasma, rabbit plasma, and cows and goats milk …”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Identification of an Analytical Method Interference for Perfluorobutanoic Acid in Biological Samples

Bangma

Reiner

Fry

et al. 2021

Environ. Sci. Technol. Lett.

View full text Add to dashboard Cite

The investigation of per- and polyfluorinated alkyl substances (PFAS) in environmental and biological samples relies on both high- and low-resolution mass spectrometry (MS) techniques. While high-resolution MS (HRMS) can be used for identification and quantification of novel compounds, low-resolution MS is the more commonly used and affordable approach for studies examining previously identified PFAS. Of note, perfluorobutanoic acid (PFBA) is one of the smaller PFAS observed in biological and environmental samples and has only one major MS/MS transition, preventing the use of qualitative transitions for verification. Recently, our laboratories undertook a targeted investigation of PFAS in the human placenta from high-risk pregnancies utilizing low-resolution, targeted MS/MS. Examination of placental samples revealed a widespread (n = 93/122 (76%)) chemical interferent in the quantitative ion channel for PFBA (213 → 169). PFBA concentrations were influenced by up to ∼3 ng/g. Therefore, additional chromatographic and HRMS/MS instrumentation was utilized to investigate the suspect peak and putatively assign the identity of the interfering compound as the saturated oxo-fatty acid (SOFA) 3-oxo-dodecanoic acid.

show abstract

Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Identification of an Analytical Method Interference for Perfluorobutanoic Acid in Biological Samples

Bangma

Reiner

Fry

et al. 2021

Environ. Sci. Technol. Lett.

View full text Add to dashboard Cite

show abstract

“…The analysis of blood plasma and serum by 1 H NMR metabolomics has proven to be a remarkable screening method in human diagnostic medicine (Emwas et al 2013;Erben et al 2018;Powell et al 2018) and for investigating important clinical conditions, such as cancer (Giskeødegård et al 2018;Lima et al 2018;Spratlin et al 2009), diabetes (Lanza et al 2010) and Parkinson's disease (Pizarro et al 2019). While NMR metabolomics applications in human health and medical sciences continue to feature numerous high quality research, the powerful analytical potential of 1 H NMR spectroscopy has led to the expansion of bloodbased metabolomics applications also to the veterinarian and animal breeding (livestock and aquaculture) fields (Başoǧlu et al 2014;Bertram et al 2006;Bin et al 2018;Dove et al 2012;Jones & Cheung, 2007;Le Moyec et al 2014;Luck et al 2015;Niemuth et al 2018;Shestakova et al 2018;Ziarrusta et al 2018). In particular, 1 H NMR metabolomics is establishing itself as an important tool for the assessment of the most relevant issues in the aquaculture industry, including fish health and alternative feed development (Alfaro & Young, 2018;Young & Alfaro, 2016).…”

Section: Introductionmentioning

confidence: 99%

The plasma metabolome of Atlantic salmon as studied by 1H NMR spectroscopy using standard operating procedures: effect of aquaculture location and growth stage

et al. 2021

View full text Add to dashboard Cite

Introduction Metabolomics applications to the aquaculture research are increasing steadily. The use of standardized proton nuclear magnetic resonance ( 1 H NMR) spectroscopy can provide the aquaculture industry with an unbiased, reproducible, and high-throughput screening tool, which can help to diagnose nutritional and disease-related metabolic disorders in farmed fish. Objective Standard operating procedures developed for analysing (human) plasma by 1 H NMR were applied to fingerprint the metabolome in plasma samples collected from Atlantic salmon. The aim was to explore the metabolome of salmon plasma in relation to growth stage and sampling site. Methods A total of 72 salmon were collected from three aquaculture sites in Norway (Lat. 65, 67, and 70 °N) and over two sampling events (December 2017 and November 2018). Plasma drawn from each salmon was measured by 1 H NMR and metabolites were quantified using the SigMa software. The NMR data was analysed by principal component analysis (PCA) and ANOVA-simultaneous component analysis (ASCA). Results Important metabolic differences were evidenced, with adult salmon having a much higher content of very lowdensity lipoproteins and cholesterol in their plasma, while smolts displayed significantly higher levels of propylene glycol. Overall, 24% of the metabolite variation was due to the growth stage, whereas 12% of the metabolite variation was related to the aquaculture site and practice (p < 0.001). ConclusionThis study provides a baseline investigation of the plasma metabolome of the Atlantic salmon and demonstrates how 1 H NMR metabolomics can be used in future investigations for comparing aquaculture practices and their influence on the fish metabolome.

show abstract

Plasma metabolomic profile in prostatic intraepithelial neoplasia and prostate cancer and associations with the prostate-specific antigen and the Gleason score

et al. 2020

View full text Add to dashboard Cite

Rabbit plasma metabolomic analysis of Nitroproston®: a multi target natural prostaglandin based-drug

Cited by 5 publications

References 30 publications

Identification of an Analytical Method Interference for Perfluorobutanoic Acid in Biological Samples

Identification of an Analytical Method Interference for Perfluorobutanoic Acid in Biological Samples

The plasma metabolome of Atlantic salmon as studied by 1H NMR spectroscopy using standard operating procedures: effect of aquaculture location and growth stage

Plasma metabolomic profile in prostatic intraepithelial neoplasia and prostate cancer and associations with the prostate-specific antigen and the Gleason score

Contact Info

Product

Resources

About