The plasma metabolome of Atlantic salmon as studied by 1H NMR spectroscopy using standard operating procedures: effect of aquaculture location and growth stage

Aru, Violetta; Khakimov, Bekzod; Sørensen, Klavs Martin; Chikwati, Elvis; Kortner, Trond M.; Midtlyng, Paul J.; Krogdahl, Åshild; Engelsen, Søren Balling

doi:10.1007/s11306-021-01797-0

Cited by 12 publications

(11 citation statements)

References 76 publications

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“…In our study, PG was detected in the plasma of fish fed with experimental feed as the yeast production included the addition of polypropylene glycol as an antifoaming agent. No detrimental effect of dietary PG on fish health has been observed in rainbow trout ( Hilton, Atkinson & Slinger, 1986 ), or in Atlantic salmon ( Aru et al, 2021 ). An increase in survival, growth performance, feed utilization, and improved immune response were identified in Nile tilapia after dietary inclusion of PG to mitigate winter stress ( Soaudy et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Oleaginous yeast Rhodotorula toruloides biomass effect on the metabolism of Arctic char (Salvelinus alpinus)

Brunel

Burkina

Picková

et al. 2022

Front. Mol. Biosci.

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Sustainability issues arise when using fish oil and vegetable oils in fish feed production for aquaculture purposes. Microbial production of single cell oil is a potential alternative as a lipid ingredient in the production of fish feed. In this study, we replaced the vegetable oils with the oleaginous yeast R. toruloides biomass in the diet of Arctic char (S. alpinus) and investigated the effects on health and composition. Measurement of fish growth parameters showed a higher liver weight and hepatosomatic index in the experimental group of fish fed partly with yeast biomass compared to a control group fed a diet with vegetable oils. No significant differences in the lipid content of muscle and liver tissues were found. The fatty acid profiles in the muscle of both fish groups were similar while the experimental fish group had a higher amount of monounsaturated fatty acids in the liver. Histology of livers showed no significant difference in the number of lipid droplets. The size of hepatic lipid droplets seemed to be related to liver fat content. Quantification of metabolites in the liver revealed no differences between the fish groups while plasma metabolites involved in energy pathways such as alanine, 3-hydroxybutyrate, creatinine, serine, betaine, and choline were significantly higher in the experimental fish group.

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Section: Discussionmentioning

confidence: 99%

Oleaginous yeast Rhodotorula toruloides biomass effect on the metabolism of Arctic char (Salvelinus alpinus)

Brunel

Burkina

Picková

et al. 2022

Front. Mol. Biosci.

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“…In our study, PG was detected in the plasma of fish fed with experimental feed as the yeast production included the addition of polypropylene glycol as an antifoaming agent. No detrimental effect of dietary PG on fish health has been observed in rainbow trout , or in Atlantic salmon (Aru et al, 2021). An increase in survival, growth performance, feed utilization, and improved immune response were identified in Nile tilapia after dietary inclusion of PG to mitigate winter stress (Soaudy et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…The yeast biomass produced was processed with a French press and added to the feed without purification or extraction steps. Nevertheless, previous studies have shown no detrimental effects of propylene glycol on salmonid health Aru et al, 2021), no effect on aquatic health and no bioaccumulation in aquatic and terrestrial organisms (West et al, 2014).…”

Section: Treatmentmentioning

confidence: 94%

Metabolites in fish and humans as a response to different food ingredients : a metabolomics approach

Brunel¹

2023

Acta Universitatis Agriculturae Sueciae

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The main objective of this thesis was to evaluate metabolomics changes in humans and fish as a response to food/feed consumption. To alleviate the environmental impact of animal production and maximize the use of resources, the valorization of meat by-products might be an attractive alternative. A meat product containing heart and aorta tissue from pork was designed and analyzed for fatty acid and metabolite composition. In comparison with a control of similar qualities, the designed meat product (or test product) showed higher monounsaturated fatty acid and tyramine levels and lower levels of sugars. The test meat product was used in a randomized controlled clinical trial to test for potential health effects in patients showing atherosclerosis symptoms. Patients receiving the test product showed a decrease in blood levels of low-density lipoproteins, total cholesterol, atherogenic index and triacylglycerols. To reduce the impact of animal production on ecosystems, the replacement of feed ingredients by a microbial alternative was realized. In this study, vegetable oils included in the feed of Arctic char (Salvelinus alpinus) were replaced by biomass of the oleaginous yeast (Rhodotorula toruloides). The analysis of the yeast biomass showed safe levels of pollutants and heavy metals. Fish growth and muscle fatty acid profile were similar to the control. A higher liver weight and hepatosomatic index were observed in fish fed including the yeast biomass, albeit no significant difference in liver fat content or in hepatic enzyme activity was observed. Quantification of plasma metabolites revealed higher levels of metabolites involved in energy pathways such as one-carbon metabolism and gluconeogenesis. In conclusion, this thesis showed that metabolomics can be applied to evaluate effects of food/feed at the molecular level in complex systems. It adds knowledge on the effects of meat by-product consumption in the particular case of atherosclerosis symptoms. The fish feed trial showed the possibility of feed modification with a specific yeast.

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“…Although transcriptomic profiles of liver in Amur ide during migration have been investigated (Cui et al, 2015;Chen et al, 2019), the physiological mechanisms behind spawning migration are still unclear. Compared to other tissues such as liver and muscle, blood is considered to be a window directly reflecting the individual's physiological state as it circulates through the entire body (Aru et al, 2021). In addition, collecting blood samples can cause the smallest damage to protected and endangered species (Zhu et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Distinctive metabolite profiles in migrating Amur ide (Leuciscus waleckii) reveal changes in osmotic pressure, gonadal development, and energy allocation strategies

Wang

Huang²,

Liang³

et al. 2022

Front. Environ. Sci.

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Amur ide (Leuciscus waleckii) lives in alkali-saline water (pH = 9.6) in the Lake Dali and spawns in freshwater rivers after migration annually. During spawning migrations, Amur ide not only experience osmoregulation modification from alkali-saline water to freshwater but also deal with energy prioritization for basal metabolism and gonadal development. To achieve an optimal cost-benefit balance, a series of metabolism modifications are needed. This study investigated the changing metabolite profiles that contribute to maintaining a balance of osmotic pressure and energy allocation for gonadal maturation. We applied ultra-performance liquid chromatography together with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS), combined with chemometrics, for identifying metabolic changes regarding spawning broodstocks of Amur ide during migration. According to findings, there were 11,333 metabolites in Amur ide serum and 3,159 metabolites were found to change significantly during migration. Differentially expressed metabolites mainly affected the steroid hormone biosynthesis, the arachidonic acid metabolism, the biosynthesis of phenylalanine, tyrosine, and tryptophan, pyruvate metabolism, citrate cycle, as well as glycerophospholipid metabolism. Based on the enrichment analysis regarding metabolic pathways, biosynthesis of steroid hormone and arachidonic acid metabolism are two representative pathways, which are crucial for osmoregulation and gonadal maturation. The perturbation of some metabolites during migration was highlighted, which involves sexual maturation and reproduction, nitrogenous waste excretion, and energy allocation. The study assists in understanding the physiological plasticity exhibited by Amur ide during migratory spawning from a new perspective, which is useful as a scientific basis for the artificial breeding of Amur ide.

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The plasma metabolome of Atlantic salmon as studied by 1H NMR spectroscopy using standard operating procedures: effect of aquaculture location and growth stage

Cited by 12 publications

References 76 publications

Oleaginous yeast Rhodotorula toruloides biomass effect on the metabolism of Arctic char (Salvelinus alpinus)

Oleaginous yeast Rhodotorula toruloides biomass effect on the metabolism of Arctic char (Salvelinus alpinus)

Metabolites in fish and humans as a response to different food ingredients : a metabolomics approach

Distinctive metabolite profiles in migrating Amur ide (Leuciscus waleckii) reveal changes in osmotic pressure, gonadal development, and energy allocation strategies

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