Rabbit Hemorrhagic Disease Viruses Detected in Pet Rabbits in a Commercial Laboratory in Europe

Marschang, Rachel E.; Weider, Karola; Erhard, Hanna; Klas, Eva-Maria; Laik-Schandelmaier, Claudia

doi:10.1053/j.jepm.2017.11.003

Cited by 4 publications

(4 citation statements)

References 16 publications

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“…All 37 rabbits that were tested for RHDV1 showed a negative result, suggesting that RHDV2 is replacing RHDV1 as the cause of RHD in the UK. This is the conclusion of several other authors (Westcott & Choudhury 2015, McGowan & Choudhury 2016, Marschang et al 2018. Replacement of RHDV1 by RHDV2 is occurring throughout Europe, although RHDV1 was still detected in a small number of cases in Germany and the Netherlands in 2016/17 (Marschang et al 2018).…”

Section: Discussionsupporting

confidence: 66%

“…This is the conclusion of several other authors (Westcott & Choudhury 2015, McGowan & Choudhury 2016, Marschang et al 2018. Replacement of RHDV1 by RHDV2 is occurring throughout Europe, although RHDV1 was still detected in a small number of cases in Germany and the Netherlands in 2016/17 (Marschang et al 2018). Replacement of RHDV1 by RHDV2 has major implications for vaccination protocols because vaccines against RHDV1 are not protective against RHVDV2 (Dalton et al 2015, Reemers et al 2017.…”

Section: Discussionmentioning

confidence: 82%

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RHDV2 epidemic in UK pet rabbits. Part 2: PCR results and correlation with vaccination status

Harcourt-Brown

Harcourt‐Brown

Joudou³

2020

J of Small Animal Practice

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To report PCR results and vaccination status of rabbits with rabbit haemorrhagic disease following an investigation into sudden or unexpected death. Materials and MethOds: PCR testing for RHDV2 and RHDV1 was performed on rabbit liver samples at two laboratories. Laboratory A reported results as positive or negative; Laboratory B reported results quantitatively as RNA copies per mg liver, categorised as negative, inconclusive or positive. The vaccination status of rabbits with both histopathological features of rabbit haemorrhagic disease and positive PCR test results were collated. results: PCR results matched histopathological findings in 188 of 195 (96%) cases. Seven individuals showed equivocal results, all of which had histopathological features of RHD but three tested PCRnegative and four results conflicted between laboratories. RHDV2 was the serotype detected in all PCR-positive cases. Histological features of rabbit haemorrhagic disease and PCR test results were positive in 125 rabbits; 51 unvaccinated, 56 in-date with Nobivac Myxo-RHD and 13 vaccinated against RHDV2-although nine of these were vaccinated within 10 days of death. clinical significance: PCR testing complements histopathology in cases of sudden death in rabbits by confirming the diagnosis and identifying virus serotype, but there can be false negatives. Although RHDV2 is currently prevalent in UK pet rabbits, vaccination against both RHDV1 and RHDV2 is recommended. Failures of RHDV2 vaccine are infrequent.

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Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 82%

RHDV2 epidemic in UK pet rabbits. Part 2: PCR results and correlation with vaccination status

Harcourt-Brown

Harcourt‐Brown

Joudou³

2020

J of Small Animal Practice

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“…RHDV2 was first detected in France in 2010 and, in the 12 years since its discovery, has spread across five continents (Rouco et al 2019;Hu et al 2021;Katayama et al 2021). It is hypothesized that the human-mediated movement of rabbits is partly responsible for the dissemination of RHDV2 globally (Mahar et al 2018;Marschang et al 2018;Rouco et al 2019).…”

Section: Introductionmentioning

confidence: 99%

“…RHDV2 poses a substantial risk to wild and domestic lagomorph populations globally (Asin et al 2021), especially since vaccinations may not be effective in young animals (Carvalho et al 2017). Studies that have evaluated RHDV2's impact in Europe found that RHDV2 (1) resulted in substantial economic losses for the commercial rabbit trade and hunting industries (Rouco et al 2019), (2) caused significant population declines (60-70%) of wild lagomorphs and associated declines in rabbit specialist predators (e.g., Iberian lynx pardinus and Spanish Imperial eagle Aquila adalberti; Monterroso et al 2016), and ( 3) is an important cause of disease in pet rabbits (Marschang et al 2018). Intensive, costly management efforts may be required to recover ecosystems that are impacted by RHDV2 due to significant alterations to ecosystem structure and function (Guerrero-Casado et al 2013;Delibes-Mateos et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Down the Rabbit Hole: Domestic Rabbit Owners’ Perceptions of Rabbit Hemorrhagic Disease Virus 2

2022

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Rabbit hemorrhagic disease virus 2 (RHDV2) is a highly contagious pathogen that infects wild and domestic rabbits and hares (lagomorphs). Globally, RHDV2 has resulted in substantial economic losses for commercial rabbit trade and caused wild lagomorph population declines. Previous research on RHDV2 suggests that human-mediated movement of rabbits may contribute to the spread of RHDV2. We conducted the first survey of individuals who own or interact with domestic rabbits to identify their rabbit husbandry behaviors and knowledge of, and concerns about, RHDV2. In 2021, we surveyed 1807 rabbit owners, breeders, and rescue staff in the USA. Respondents had a high level of knowledge about RHDV2. Respondents believed RHDV2 posed a high risk to rabbit-related activities and were concerned about its economic and ecological impacts. Nearly half of respondents always kept their rabbits indoors, but 10.7% of respondents allowed their rabbits outside frequently on properties used by wild lagomorphs. Respondents with five rabbits or less were generally willing to vaccinate their rabbits, but respondents with larger herds argued that vaccines were cost prohibitive. Given respondents' concerns about RHDV2, communication about disease prevention should highlight the adverse ecological and economic consequences of RHDV2.

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Understanding rabbit owners’ willingness to engage in disease prevention behaviors

Shapiro,

Ruder,

Nimlos

et al. 2023

Preventive Veterinary Medicine

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Rabbit Hemorrhagic Disease Viruses Detected in Pet Rabbits in a Commercial Laboratory in Europe

Cited by 4 publications

References 16 publications

RHDV2 epidemic in UK pet rabbits. Part 2: PCR results and correlation with vaccination status

RHDV2 epidemic in UK pet rabbits. Part 2: PCR results and correlation with vaccination status

Down the Rabbit Hole: Domestic Rabbit Owners’ Perceptions of Rabbit Hemorrhagic Disease Virus 2

Understanding rabbit owners’ willingness to engage in disease prevention behaviors

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