Rabbit as an animal model for experimental research

“…These animals have a non-aggressive character, so they are easily bred and handled. [ 17 ] Autologous bone marrow aspirate can be obtained with ease up to 5 ml. [ 12 ] Bone marrow aspirate cannot be obtained from smaller animals without sacrificing them.…”

Section: Discussionmentioning

confidence: 99%

A new rabbit model of impaired wound healing in an X-ray-irradiated field

et al. 2017

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Radiation is an important therapy for cancer with many benefits; however, its side effects, such as impaired wound healing, are a major problem. While many attempts have been made to overcome this particular disadvantage, there are few effective treatments for impaired wound healing in an X-ray-irradiated field. One reason for this deficiency is the lack of experimental models, especially animal models. We have previously reported a mouse model of impaired wound healing in which the irradiation area was restricted to the hindlimbs. In this mouse model, due to the size of the animal, a diameter of five millimeters was considered the largest wound size suitable for the model. In addition, the transplanted cells had to be harvested from other inbred animals. To investigate larger wounds and the impact of autologous specimen delivery, a rabbit model was developed. Rabbits were kept in a special apparatus to shield the body and hindlimbs while the irradiation field was exposed to radiation. Six weeks after irradiation, a 2 x 2 cm, full-thickness skin defect was made inside the irradiation field. Then, the wound area was observed over time. The wound area after irradiation was larger than that without irradiation at all time points. Both angiogenesis and collagen formation were reduced. For further study, as an example of using this model, the effect of autologous platelet-rich plasma (PRP) was observed. Autologous PRP from peripheral blood (pb-PRP) and bone marrow aspirate (bm-PRP) was processed and injected into the wounds in the irradiated field. Two weeks later, the wounds treated with bm-PRP were significantly smaller than those treated with phosphate buffer vehicle controls. In contrast, the wounds treated with pb-PRP were not significantly different from the controls. This rabbit model is useful for investigating the mechanism of impaired wound healing in an X-ray-irradiated field.

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“…The movie Get Out (2017) uses it as a hint about the danger the Black man is facing through race opposition. The scene implies that 'run' means 'avoid', while 'rabbit' refers to 'Logan King' in this case because a rabbit is usually used as an experimental object (Thomas, Bhat, & Mapara, 2012) in operation, which is similar to Logan King in the movie. Being a weak being, compared to a rabbit, he is told to run away from White people.…”

Section: Distinctive Music To Show Oppressionmentioning

confidence: 99%

Musical Aspects for Empowering the Black Characters in the Movie Get Out (2017)

Marasabessy

Handayani

2019

Resital

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In the 21st century, the representation of Black people in many U.S. movies is still problematic, for the movies do not omit the stereotypical representations of Black people, which are often depicted being disrespectful and unintelligent compared to other races. Many movies have been trying to change them into another perspective, yet they are still unable to get rid of those stereotypes completely. By looking through the cinematic aspects, the dialogues, and the symbols along with the sounds and music used, this paper examines the stereotypes of Black characters in the movie Get Out (2017) by Jordan Peele using discourse analysis. The paper observes that the representation of the movie still distinguishes Black from White in the aspects of the body over mind in Black masculinity, incivility, and distinctive racial labour. As a result, Black characters are seen inferior compared to White characters despite the movie's effort to empower them. The use of music also emphasizes the power relation difference between the two races. The overall finding of the paper reveals that the existence of Black stereotypical depiction is still found in a movie empowering Black people, and it shows that race representation should be monitored thoroughly. ABSTRAKAspek Musikal untuk Memberdayakan Karakter Kulit Hitam di Film Get Out (2017). Pada abad ke-21 ini, representasi orang kulit hitam di banyak film Amerika problematis karena film-film tersebut tidak menghilangkan representasi stereotip orang kulit hitam yang mana sering digambarkan tidak sopan dan kurang cerdas dibandingkan dengan ras lain. Banyak film sudah mencoba mengubah stereotip tersebut ke perspektif lain, namun film-film tersebut masih belum dapat sepenuhnya menghapuskan stereotip yang ada. Dengan melihat aspek sinematik, dialog, simbol, suara, dan musik yang digunakan, artikel ini menganalisis stereotip karakter orang kulit hitam dalam film Get Out (2017) oleh Jordan Peele menggunakan analisis wacana. Artikel ini menemukan bahwa keseluruhan representasi dalam film tersebut masih memisahkan kulit hitam dari kulit putih dengan lebih mengutamakan aspek tubuh daripada pikiran dalam maskulinitas kulit hitam, sikap yang tidak sopan, dan perbedaan jenis pekerjaan. Sebagai hasilnya, karakter kulit hitam terlihat inferior dibandingkan karakter kulit putih meskipun film ini berusaha untuk memberdayakan orang kulit hitam. Penggunaan musik juga menekankan adanya perbedaan kekuasaan antara kedua ras. Keseluruhan hasil analisis dari artikel menemukan bahwa penggambaran stereotip orang kulit hitam masih terlihat dalam film yang memberdayakan orang kulit hitam. Hal ini menunjukkan bahwa representasi ras menuntut pengamatan secara mendalam.

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Rabbit as an animal model for experimental research

Cited by 187 publications

References 11 publications

Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection

Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection

A new rabbit model of impaired wound healing in an X-ray-irradiated field

Musical Aspects for Empowering the Black Characters in the Movie Get Out (2017)

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