The large volume vacuum systems are used in many industrial operations and research laboratories. Accidents in these systems should have a relevant economical and safety impact. A loss of vacuum accident (LOVA) due to a failure of the main vacuum vessel can result in a fast pressurization of the vessel and consequent mobilization dispersion of hazardous internal material through the braches. It is clear that the influence of flow fields, consequence of accidents like LOVA, on dust resuspension is a key safety issue. In order to develop this analysis an experimental facility is been developed: STARDUST. This last facility has been used to improve the knowledge about LOVA to replicate a condition more similar to appropriate operative condition like to kamaks. By the experimental data the boundary conditions have been extrapolated to give the proper input for the 2D thermofluid-dynamics numerical simulations, developed by the commercial CFD numerical code. The benchmark of numerical simulation results with the experimental ones has been used to validate and tune the 2D thermofluid-dynamics numerical model that has been developed by the authors to replicate the LOVA conditions inside STARDUST. In present work, the facility, materials, numerical model, and relevant results will be presented.