Quinoxaline, its derivatives and applications: A State of the Art review

Pereira, Joana A.; Moura, Ana S.; Cordeiro, M. Natália D. S.; Fernandes, Rúben; Prudêncio, Cristina; Noronha, João Paulo; Vieira, Mónica

doi:10.1016/j.ejmech.2014.06.058

Cited by 336 publications

(111 citation statements)

References 64 publications

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“…Quinoxaline and its derivatives are very industrially important because of their ability to inhibit metal corrosion [34] in the preparation of porphyrins [35]. The pharmaceutical industry has a potential interest in them because of their broad spectrum of biological properties [36][37][38].…”

Section: Citationmentioning

confidence: 99%

Bio-Oil Production by Thermal Cracking in the Presence of Hydrogen

Veses¹,

Shah²

2015

J Fundam Renewable Energy Appl

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This paper describes the bio-oil production process of a mixture of agricultural wastes: discarded soybean frying oil, coffee and sawdust, by pyrolysis and thermal cracking in the presence of hydrogen. The fractions obtained in the pyrolysis and/or cracking processes were divided into a light fraction and a heavy one. All the fractions were analyzed by comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry detection (GC×GC/ TOFMS). The characteristics of the fractions obtained in from the cracking process in the presence of hydrogen were similar to those of petroleum-based naphtha, while the fractions obtained by pyrolysis contained significant quantities of compounds such as furanmethanol, hexanol, and benzofuran, whose commercial value is high.

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Section: Citationmentioning

confidence: 99%

Bio-Oil Production by Thermal Cracking in the Presence of Hydrogen

Veses¹,

Shah²

2015

J Fundam Renewable Energy Appl

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“…Quinoxaline nucleus forms an important part of active pharmacophore in synthesis of wide range of biological active compounds used as antibacterial, 27,28 antiviral, 29,30 anti-HIV, 31 antimalarial, 32,33 anticancer, [34][35][36] antitubercular, 37 antileishmanial, 38 and various neurological disorders. 39,40 Based on our interest in sustainable green chemistry, herein, we have developed a methodology where complex ketones which have pharmacologically important moiety can be reduced using a cheap and easy process with D carota as the catalyst.…”

Section: Introductionmentioning

confidence: 99%

Green synthesis of enantiopure quinoxaline alcohols using Daucus carota

et al. 2019

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Green chemistry comprises a new approach in the synthesis of biologically active compounds using biocatalysts, thus diminishing the hazards for human health and environmental pollution. Asymmetric bioreduction is one of the most widely employed strategies in chemoenzymatic synthesis to produce enantiomerically pure chiral alcohols. The present study highlights the use biocatalyst Daucus carota for selective bioreduction of quinoxaline ketones 1a-6a to their corresponding optically pure alcohols 1b-6b in high yields (up to 84%) and good enantioselectivity (up to 98%). The absolute configuration of the chiral product (R)-1-(3-methyl 7-nitroquinoxalin-2-yl) ethan-1-ol 2b was confirmed by X-ray crystallography studies. The chiral R-configuration of the products obtained was confirmed by absolute configuration studies and was assigned following anti-Prelogs rule. Quinoxaline pharmacophores form a part of well-known potent drug molecules; hence, the chiral products were studied for determination of their molecular properties using SwissADME property analyser. All the chiral products show no Lipinski rule violations and are expected to have good oral bioavailability. As per the molecular properties prediction studies, the compound 6b (R)-1- (6,7-dichloro-3-methylquinoxalin-2-yl) ethanol is observed to show the best physicochemical properties to be a good lead molecule. Thus, the sustainable methodology was developed, and it confirms the synthesis of novel quinoxaline chiral alcohols in a simple, inexpensive, and eco-friendly condition using D carota.

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“…In the recent year, 2,3-disubstituted quinoxalines reported to posse's significant potential against parasites, bacteria, fungi, and mycobacterium. [2] Design of quinoxaline antibiotics have undertaken by several workers, [3] but they posses limited application due to their toxic effect. We undertaken the molecular docking studies of these compounds to evaluate the binding affinities of the synthesized compounds with enzyme asparginyl t-RNA synthetase (PDB: 2kqr).…”

Section: Introductionmentioning

confidence: 99%

APPLICATION OF COMPUTATIONAL STRATEGIES FOR OPTIMIZATION OF ASPARGINYL t-RNA SYNTHETASE DOCKING STUDY OF QUINOXALINES

Ingle¹

2017

WJPR

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The potential use of asparginyl t-RNA synthetase inhibitors as antifilarial agents for the treatment of filariasis. In our present work we have synthesized series of diphenyl quinoxalines derivatives.Molecular docking studies of these compounds were undertaken to evaluate the binding affinities of the compounds with enzyme asparginyl t-RNA synthetase (PDB: 2kqr). The current result shows fine correlation in enzyme inhibitory activity with docked ligand.

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Quinoxaline, its derivatives and applications: A State of the Art review

Cited by 336 publications

References 64 publications

Bio-Oil Production by Thermal Cracking in the Presence of Hydrogen

Bio-Oil Production by Thermal Cracking in the Presence of Hydrogen

Green synthesis of enantiopure quinoxaline alcohols using Daucus carota

APPLICATION OF COMPUTATIONAL STRATEGIES FOR OPTIMIZATION OF ASPARGINYL t-RNA SYNTHETASE DOCKING STUDY OF QUINOXALINES

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