Quinolones for uncomplicated acute cystitis in women

Rafalskiy, Vladimir V.; Andreeva, Irina V.; Rjabkova, Elena L

doi:10.1002/14651858.cd003597.pub2

Cited by 37 publications

(30 citation statements)

References 56 publications

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“…Enoxacin (ENX) is an oral broad-spectrum fluoroquinolone antibacterial agent effective against many Gram-positive and -negative bacteria, 18 and it also possesses anticancer properties because of its ability to enhance microRNA activity. 19 ENX also blocks osteoclastogenesis and bone resorption without altering the expression levels of numerous osteoclast-specific proteins.…”

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confidence: 99%

Periodontitis in Rats Induces Systemic Oxidative Stress That Is Controlled by Bone‐Targeted Antiresorptives

Oktay

Chukkapalli

Rivera‐Kweh

et al. 2015

Journal of Periodontology

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Background Periodontitis is a chronic, polymicrobial inflammatory disease that degrades connective tissue and alveolar bone and results in tooth loss. Oxidative stress has been linked to the onset of periodontal tissue breakdown and systemic inflammation, and the success of antiresorptive treatments will rely on how effectively they can ameliorate periodontal disease–induced oxidative stress during oral infection. Methods Rats were infected with polybacterial inoculum consisting of Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia, as an oral lavage every other week for 12 weeks. Daily subcutaneous injections of enoxacin, bisenoxacin, alendronate, or doxycycline were administered for 6 weeks after 6 weeks of polybacterial infection in rats. The serum levels of oxidative stress parameters and antioxidant enzymes, including glutathione peroxidase, superoxide dismutase, and catalase, were evaluated in each of the infected, treated, and sham-infected rats. Results Rats infected with the periodontal pathogens displayed a five-fold increase in the oxidative stress index compared with controls as a result of increased levels of serum oxidants and decreases in total antioxidant activity. The overall decrease in antioxidant activity occurred despite increases in three important antioxidant enzymes, suggesting an imbalance between antioxidant macromolecules/small molecules production and antioxidant enzyme levels. Surprisingly, the bone-targeted antiresorptives bis-enoxacin and alendronate inhibited increases in oxidative stress caused by periodontitis. Bis-enoxacin, which has both antiresorptive and antibiotic activities, was more effective than alendronate, which acts only as an antiresorptive. Conclusion To the best of the authors’ knowledge, this is the first study to demonstrate that the increased oxidative stress induced by periodontal infection in rats can be ameliorated by bone-targeted antiresorptives.

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mentioning

confidence: 99%

Periodontitis in Rats Induces Systemic Oxidative Stress That Is Controlled by Bone‐Targeted Antiresorptives

Oktay

Chukkapalli

Rivera‐Kweh

et al. 2015

Journal of Periodontology

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“…Specifically, a 3-day course of ciprofloxacin 500 mg oral bid (twice a day), ciprofloxacin 500 mg SR (sustained-release) oral tid (three times a day), or tosufloxacin 150 mg oral bid is recommended [9]. Levofloxacin has not been approved to treat uncomplicated cystitis in Korea; and as such, there may be insurance-related problems if used.…”

Section: Treatmentmentioning

confidence: 99%

2017 Guidelines of The Korean Association of Urogenital Tract Infection and Inflammation: Acute Uncomplicated Cystitis

Kim

Lee

Cho

et al. 2017

Urogenit Tract Infect

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Acute uncomplicated cystitis is the most common urinary tract infection that mainly occurs in adult females, particularly sexually active young women and postmenopausal women. It is commonly observed in primary health care settings, including urology as well as obstetrics and gynecology; more than half of healthy adult women visit clinics and hospitals at least once in their lifetime due to acute uncomplicated cystitis. The most common bacterium causing this condition is Escherichia coli, followed by Staphylococcus saprophyticus, Klebsiella pneumoniae, Proteus mirabilis, and etc. Trimethoprim-sulfamethoxazole or fluoroquinolones have been used as an empirical antibiotic treatment. However, as fluoroquinolone-resistant organisms or extended spectrum beta-lactamase-producing organisms are becoming more prevalent worldwide, information on regional antibiotic resistance and guidelines on antibiotic use are becoming increasingly more desparate.

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“…A recent meta-analysis study has shown that fluoroquinolones (ciprofloxacin and gatifloxacin) are the most effective therapy for uncomplicated UTI in comparison with other antimicrobials37. According to a Cochrane analysis all fluoroquinolones (at comparable dosages) suitable for the treatment of UTI showed the same effectiveness for this indication but tolerability differed [38]. Thus, fluoroquinolones remain very effective for the treatment of acute cystitis, although increased fluoroquinolone resistance among community uropathogens is limiting the usefulness of this antimicrobial class [1][2][3]7,37].…”

Section: Management Of Acute Uncomplicated Cystitismentioning

confidence: 99%

Treatment of acute uncomplicated cystitis - A clinical review

Aliaga¹,

Moreno²,

Aomar³

et al. 2017

Clin Med Invest

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Quinolones for uncomplicated acute cystitis in women

Abstract: Analysis 1.3. Comparison 1 200 mg/d sparfloxacin versus 400 mg/d ofloxacin, Outcome 3 Clinical + microbiological e icacy...... Analysis 1.4. Comparison 1 200 mg/d sparfloxacin versus 400 mg/d ofloxacin, Outcome 4 Safety.

Cited by 37 publications

References 56 publications

Periodontitis in Rats Induces Systemic Oxidative Stress That Is Controlled by Bone‐Targeted Antiresorptives

Periodontitis in Rats Induces Systemic Oxidative Stress That Is Controlled by Bone‐Targeted Antiresorptives

2017 Guidelines of The Korean Association of Urogenital Tract Infection and Inflammation: Acute Uncomplicated Cystitis

Treatment of acute uncomplicated cystitis - A clinical review

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