Quinolone derivatives and their antifungal activities: An overview

Zhang, Bo

doi:10.1002/ardp.201800382

Cited by 25 publications

(8 citation statements)

References 109 publications

(92 reference statements)

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“…There are numerous compounds in development that have been included in several recently published review articles [ 247 , 263 ]. The discovery of new potential drugs is in continuous progress.…”

Section: Compounds In Development Based On Antibacterial Qns Structuresmentioning

confidence: 99%

“…This compound has been shown to be active against Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus agalactiae [ 268 ]. In a review article, Zhang Bo (2014) highlighted different series of QN derivatives with antifungal potential in terms of structure-activity relationship: 2-quinolone, 4-quinolone, and FQN derivatives and FQN-metal complexes [ 263 ]. Lapointe et al (2021) recently published the discovery and optimization of a novel series of compounds that inhibit the two bacterial target enzymes and stabilize the DNA cleavage complexes [ 269 ].…”

Section: Compounds In Development Based On Antibacterial Qns Structuresmentioning

confidence: 99%

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Structural Characterization of the Millennial Antibacterial (Fluoro)Quinolones—Shaping the Fifth Generation

et al. 2021

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The evolution of the class of antibacterial quinolones includes the introduction in therapy of highly successful compounds. Although many representatives were withdrawn due to severe adverse reactions, a few representatives have proven their therapeutical value over time. The classification of antibacterial quinolones into generations is a valuable tool for physicians, pharmacists, and researchers. In addition, the transition from one generation to another has brought new representatives with improved properties. In the last two decades, several representatives of antibacterial quinolones received approval for therapy. This review sets out to chronologically outline the group of approved antibacterial quinolones since 2000. Special attention is given to eight representatives: besifloxacin, delafoxacin, finafloxacin, lascufloxacin, nadifloxacin and levonadifloxacin, nemonoxacin, and zabofloxacin. These compounds have been characterized regarding physicochemical properties, formulations, antibacterial activity spectrum and advantageous structural characteristics related to antibacterial efficiency. At present these new compounds (with the exception of nadifloxacin) are reported differently, most often in the fourth generation and less frequently in a new generation (the fifth). Although these new compounds’ mechanism does not contain essential new elements, the question of shaping a new generation (the fifth) arises, based on higher potency and broad spectrum of activity, including resistant bacterial strains. The functional groups that ensured the biological activity, good pharmacokinetic properties and a safety profile were highlighted. In addition, these new representatives have a low risk of determining bacterial resistance. Several positive aspects are added to the fourth fluoroquinolones generation, characteristics that can be the basis of the fifth generation. Antibacterial quinolones class continues to acquire new compounds with antibacterial potential, among other effects. Numerous derivatives, hybrids or conjugates are currently in various stages of research.

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Section: Compounds In Development Based On Antibacterial Qns Structuresmentioning

confidence: 99%

Section: Compounds In Development Based On Antibacterial Qns Structuresmentioning

confidence: 99%

Structural Characterization of the Millennial Antibacterial (Fluoro)Quinolones—Shaping the Fifth Generation

et al. 2021

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“…Oral ciprofloxacin or intravenous injections are used for treatment of bone infections " [7]", febrile neutropenia, and anthrax " [8]", gastrointestinal infections " [9]", lower respiratory tract infections and pneumonia " [10]", chronic bacterial prostatitis and urinary tract infection " [11]", and complicated pyelonephritis in pediatrics " [12]". Various quinolone derivatives have been screened for their antifungal activities, and was seen exhibited potency against fungi " [13]". But they exhibit a low antiviral activity against SARS-CoV-2 and MERS-CoV " [14]".…”

Section: Clinical Indications For Ciprofloxacinmentioning

confidence: 99%

Ciprofloxacin Chemistry, Medical Evaluation and Adverse Effect with Special Attention to Ciprofloxacin Chondrotoxicity

et al. 2021

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Ciprofloxacin is the most potent fluoroquinolone and was seen active against a broad range of bacteria. The present study was aimed to review all published animals and human studies in the medical and dental literature about ciproflo period between 1995 and 2021. English language publications, original studies and reviews were included.Several researchers revealed that ciprofloxacin can causes arthropathy. Chondrotoxicity seen in juvenile animals could be due to the de functionally available magnesium, production of oxidative stresses and lipid peroxidation, chondrocytes loss, decrease in the formation of the cartilage extracellular matrix, decrease in sox9 expression, increase caspase expression.In human, ciprofloxacin can induce tendinopathy and tendon rapture. with ciprofloxacin, showed that only a few percentages of them had developed a ciprofloxacin cannot cause any permanent joint damage. T indicatedthat ciprofloxacin may be a safe drug to be used in children under the age of 18 years old, but only used when there is no a good alternative to its use until a long

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“…Ciprofloxacin, a yellowish crystalline substance, is a monohydrochloride monohydrate salt of 1cyclopropyl-6-fluoro-1, 4-dihydro-4-oxo- [8]", anthrax " [9]", gastrointestinal infections " [10]", Lower respiratory tract infections " [11]", urinary tract infection " [12]", and complicated pyelonephritis " [13]". Various fluoroquinolone derivatives have been screened for their antifungal activities, and was seen exhibited potency against fungi " [14]", but they exhibit a low antiviral activity against SARS-CoV-2 and MERS-CoV " [15]". Ciprofloxacin is readily absorbed following oral administration, but the absolute bioavailability is within a range of 70-80% for the oral dose.…”

Section: Introductionmentioning

confidence: 99%

Ciprofloxacin Chondrotoxicity, A Biochemical Analysis for Serum Magnesium, Calcium, Zinc, and Vitamin E in Wistar Albino Rats

et al. 2021

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Ciprofloxacin is the most potent fluoroquinolone and was seen active against a broad range of bacteria. Several researchers revealed that ciprofloxacin can caused a chondrotoxic effects and supplementation with magnesium, calcium, zinc or vitamin E can diminished the induced chondrotoxicity. The aim of present study was to assess the rat's serum magnesium, calcium, zinc, and vitamin E, after the subcutaneous injections of ciprofloxacin to male Wistar rats. Ten rats were used in the study and divided in to two equal groups. On day 32 of age, all the animals in the control group were subcutaneously injected by physiological saline, while the animals in study group were subcutaneously injected by 600 mg/kg b.w. of ciprofloxacin eight hours apart. On day 34 of age, rats were anaesthetized and blood collection by cardiac puncture was taken. The present study revealed that mean serum levels for rat's magnesium, calcium, and zinc in the control group were 2.258±0.199 mg/dl, 9.416±0.369 mg/dl, and 95.51±1.81 µg/dl respectively, and the mean serum levels for rat's magnesium, calcium, and zinc in the study group were 2.138±0.257mg/dl, 9.254±0.292 mg/dl, and 94.19±2.929µg/dl respectively; The mean serum levels for vitamin E in the control and study group were 23.772±1.029 and 21.97±1.419 ng/ml respectively. Statistical analysis showed that ciprofloxacin hydrochloride caused a non-significant decrease in rat's serum magnesium, calcium, zinc, and vitamin E levels (p>0.05). The research concluded that ciprofloxacin chondrotoxicity was not caused by the decrease in rat's serum magnesium, calcium, zinc, and vitamin E levels, and other researchers are recommended to measure their levels in the chondroid tissue after ciprofloxacin therapy.

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Quinolone derivatives and their antifungal activities: An overview

Cited by 25 publications

References 109 publications

Structural Characterization of the Millennial Antibacterial (Fluoro)Quinolones—Shaping the Fifth Generation

Structural Characterization of the Millennial Antibacterial (Fluoro)Quinolones—Shaping the Fifth Generation

Ciprofloxacin Chemistry, Medical Evaluation and Adverse Effect with Special Attention to Ciprofloxacin Chondrotoxicity

Ciprofloxacin Chondrotoxicity, A Biochemical Analysis for Serum Magnesium, Calcium, Zinc, and Vitamin E in Wistar Albino Rats

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