The majority of salivary glands tumors are benign mixed tumors. The present study was aimed to evaluate the differences between benign mixed salivary glands tumor and papillary cystadenoma lymphomatous regarding the tumor cell proliferation rate, apoptotic and antiapoptotic activity. The study was performed on archived paraffinembedded salivary glands tissue of 23 benign mixed tumors and five cystadenoma lymphomatosis. Sections were stained with hematoxylin and eosin and cases with the definite diagnosis were selected for immunohistochemistry. The immunoreactivity was assessed in areas of highest positivity regarding Ki-67, P53, and bcl-2. Our results refer that benign mixed tumor and papillary cystadenoma lymphomatous showed negative immune expression for Ki-67. The P53 immune staining in benign mixed tumor appeared negative, while the papillary cystadenoma lymphomatous appeared with mild positive staining. Bcl-2 immune expression in the benign mixed tumor was moderate positive while the papillary cystadenoma lymphomatous was mild positive. We conclude that the benign mixed tumors showed significantly more Ki-67 and bcl-2 immune labeling indexes than papillary cystadenoma lymphomatous, but the P53 immune expression was less (p<0.05). This indicates that the P53 expression was not observed to be correlated with the Ki-67 or bcl-2 overexpression.
Ciprofloxacin is the most potent fluoroquinolone and was seen active against a broad range of bacteria. The present study was aimed to review all published animals and human studies in the medical and dental literature about ciproflo period between 1995 and 2021. English language publications, original studies and reviews were included.Several researchers revealed that ciprofloxacin can causes arthropathy. Chondrotoxicity seen in juvenile animals could be due to the de functionally available magnesium, production of oxidative stresses and lipid peroxidation, chondrocytes loss, decrease in the formation of the cartilage extracellular matrix, decrease in sox9 expression, increase caspase expression.In human, ciprofloxacin can induce tendinopathy and tendon rapture. with ciprofloxacin, showed that only a few percentages of them had developed a ciprofloxacin cannot cause any permanent joint damage. T indicatedthat ciprofloxacin may be a safe drug to be used in children under the age of 18 years old, but only used when there is no a good alternative to its use until a long
Objective: Green tea (GT) contains polyphenolic flavonoids, different minerals like magnesium, calcium, and zinc, vitamins, amino acids, carbohydrates, proteins, and others. It has a different health benefit. The aim of the present study was to investigate the effect of intragastric gavage of a high dose GT extract on serum biochemical analysis of magnesium, calcium, and zincin juvenile Wistar albino rats. Methods: Twelve rats were used in the study and divided in to two equal groups. All the animals in the control group were intragastically gavaged by distilled water and continues for ten days, from day 24 to day 34 of age, while the animals in the study group were intragastically gavaged by GT extract (300mg/kg/day) which continues also for ten days from day 24 to day 34 of age. On day 34 of age, and two hours after the last dose, the rats were anaesthetized and blood collection by cardiac puncture was taken. Results: The results showed that the intragastric gavage of a high dose of GT extract caused a non-significant increase in serum magnesium, and calcium levels (p>0.05), but a significant increase in zinc serum level was seen(p< 0.05). Conclusion: GT can cause a significant increase in zinc serum level, and this may explain the significant role of GT in the response to different oxidative stress. It is recommended to measure the Zn serum level in rats after a period longer than two hrs from the time of the last dose of intragastric gavage of GT extract.
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