Quinolizidine Alkaloids in<i>Spartium junceum</i>

Lurz, G.; Greinwald, Roland; Witte, Ludger; Czygan, F.-C.

doi:10.1055/s-2006-961076

Cited by 6 publications

(5 citation statements)

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“…We found, in agreement with Lurz et al (1990), that the epigeal part of the plant is richer in alkaloids and flavonoids at the beginning of the flowering cycle than at the beginning of the vegetative cycle (Table 1). We found, in agreement with Lurz et al (1990), that the epigeal part of the plant is richer in alkaloids and flavonoids at the beginning of the flowering cycle than at the beginning of the vegetative cycle (Table 1).…”

Section: Alkaloidssupporting

confidence: 88%

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Evaluation of the antifertility activity of the broomSpartium junceumin the mammalian male

Baccetti¹,

Burrini²,

Chen³

et al. 1993

Zygote

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Male adult rabbits and rats treated with Spartium junceum showed a significant decrease in fertility, demonstrated by a lower number of pregnancies. The target of the drug seems to be the acrosomal protease system, the activity of which appears greatly reduced, while the morphology of testicular cells and epididymal spermatozoa is only partially affected. The antifertility effect is completely reversible.

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Section: Alkaloidssupporting

confidence: 88%

“…Most of the alkaloids and flavonoids are present in the flowers and in the ripe fruits. We found, in agreement with Lurz et al (1990), that the epigeal part of the plant is richer in alkaloids and flavonoids at the beginning of the flowering cycle than at the beginning of the vegetative cycle (Table 1).…”

Section: Alkaloidssupporting

confidence: 88%

Evaluation of the antifertility activity of the broomSpartium junceumin the mammalian male

Baccetti¹,

Burrini²,

Chen³

et al. 1993

Zygote

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“…Greinwald et al, 44 reported that there were significant differences in the amount of alkaloid between the different parts of the plant, the alkaloid content varied depending on the seasons, while there was a limited variation in the amount of alkaloid according to geographical origin. In the various parts of S. junceum, especially the flowers, quinolinidine alkaloids (cyticin, N-methylcithin, anagirin) were also isolated [16][17][18]45 . Some other alkaloids, especially quinolizide alkaloids, were reported to show antiviral activity against herpes viruses [46][47] .…”

Section: Resultsmentioning

confidence: 99%

“…The antimicrobial, antioxidant and cytotoxic activities of aromatic water obtained from S. junceum flowers were investigated, and it was determined that aromatic water had a significant cytotoxic and antioxidant activity 15 . Researchers have shown that this plant contains high amounts of quinolizidine alkaloids [16][17][18] , flavonoids (flavonols, isoflavones, flavones) 19 , triterpenoid saponin 20 and proanthocyanidin 21 , including sparteine showing interesting biological activities.…”

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confidence: 99%

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2019

IJPSR

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This study was carried out to evaluate the antiviral activities of methanol and aqueous extracts prepared from the flowers and stems of Spartium junceum L., used as herbal medicine in the treatment of gastric ulcer in Turkish folk medicine, against herpes simplex virus type 1 (HSV-1). The maximum non-toxic concentration of the extracts (MNTC) was determined against Vero cells by using the serial twofold dilution of MNTC (specific for each extract). The cytotoxic activity of the extracts and their ability to inhibit the cytopathic effect (CPE) caused by the virus in tissue culture was evaluated by colorimetric XTT assay after three days of inoculation and incubation. 50% cytotoxic concentration (CC 50) and 50% effective concentration (EC 50) were determined using graph pad prism, and the selectivity index (SI) was calculated from the EC 50 ratio of CC 50. As a result of the research, the strongest antiviral activity against HSV-1 was determined from flower aqueous extract with 1290.88 μg/mL EC 50 and 24.09 SI values, and this was followed by stem aqueous extract (EC 50 = 1217.52 μg/mL, SI = 12.22), flower methanol (EC 50 = 1673.41 μg/mL, SI = 6.74) and stem methanol extracts (EC 50 = 795.31 μg/mL, SI = 4.86). As a result, we can say that S. junceum extracts are worthy of further study to develop as an alternative to the drugs used clinically against HSV-1. This is the first report on S. junceum for anti-HSV-1 activity. INTRODUCTION: Herpes simplex virus type 1 (HSV-1) in the herpesviridae family is an enveloped double-stranded DNA virus 1. HSV-1 infections are common and contagious. Approximately 60% to 90% of the adult world population is seropositive for HSV-1 2 .

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“…Recently, the production and distribution of alkaloids has been investigated in the different plant parts, at different stages of its life cycle (4,5). Yesilada et al recorded the utilization of a flower infusion for the treatment of gastric ulcers in southern Anatolia (6); a recent study on S. junceum justified this traditional use, demonstrating the potent anti-ulcerogenic activity of the flowers, due to the presence of an oleanene-type saponin (7).…”

Section: Introductionmentioning

confidence: 99%

Identification of Volatile Constituents from the Flower Oil ofSpartium junceum

Miraldi¹,

Ferri²,

Giorgi³

2004

Journal of Essential Oil Research

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The essential oil, isolated by hydrodistillation from fresh flowers of Spartium junceum L., was investigated by GC and GC/MS. The 24 main constituents of the samples were identified; the main components of the oil were kairomonal compounds, tricosane (22.9%), tetracosane (8.9%) and pentacosane (16.1%), constituting altogether almost 48% of total composition. These hydrocarbons constitute an important aspect governing the sensitivity of the insects in plant host selection.

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Quinolizidine Alkaloids inSpartium junceum

Cited by 6 publications

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Evaluation of the antifertility activity of the broomSpartium junceumin the mammalian male

Evaluation of the antifertility activity of the broomSpartium junceumin the mammalian male

Untitled

Identification of Volatile Constituents from the Flower Oil ofSpartium junceum

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