Quinolines VI. Some 4-Aminoquinoline Derivatives

Abstract

Reduced Mannich Product Derived from V.-The ManFound: C1, 12.0; IT, 14.4. 17.6. Found: C, 45.6; H, 3.81; N, 17.3. nich product was hydrogenated in the usual manner with Summary palladized charcoal catalyst at two atmospheres for two hours using methanol as a solvent. The product after Directions for the synthesis 214-divacuum drying ai: 50 O was a very hygroscopic yellow plastic methyl-8-quinazolyl ketone and 4-hydroxy-8-quinsolid which gave no definite melting point. azoline carboxylic acid from 2-nitroisophthalic The dipicrate of the amino alcohol was prepared from the acid are given. ethereal solutions of both the free base and picric acid, m. p. 92-94'.

Molecular and Biological Aspects of Antimalarial Resistance in Plasmodium falciparum and Plasmodium vivax

“…Since the medicinal properties of the Peruvian bark were discovered in XVII century, its active molecule Quinine (QN) is used to treat malaria [6]. During the 30's, Andersag investigated the action of two structurally related 4-aminoquinolines [8]. The 7-chloroquinoline and the 6-methoxyquinoline were shown to have excellent activity.…”

Structural modification study of bis(substituted aminoalkylamino)anthraquinones. An evaluation of the relationship of the [2-[(2-hydroxyethyl)amino]ethyl]amino side chain with antineoplastic activity

“…The The chloroquine analogue 6 was prepared according to the procedure of Steck et al6 The naphthoquinone derivatives 7a and 7b were prepared by treatment of 1,4-naphthoquinone with 2-[(2-aminoethyl)amino]ethanol and [2-(dimethylamino)ethyl]amine, respectively. Compounds 7c and 7d were prepared in a similar manner from 2,3dichloro-1,4-naphthoquinone and the appropriate amine.…”