Quinoline – a Promising Fragment in the Search for New Antimalarials

Abstract

Malaria continues to be a potentially fatal threat to almost half of the world's population. In the present review, efforts have been made to provide a literature concerning the study of quinoline as a privilege structure for search of new malarials. The review covers advances in that field made in few last years.

7-Hydroxy-4-phenyl-1, 2-dihydroquinoline derivatives: synthesis via one-pot, three-component reaction and structure elucidation

“…They show excellent antiviral activity against dengue virus [ 11 ], zika virus [ 12 ], avian influenza virus [ 13 ] and now in recent pandemic conditions against COVID-19 [ 14 , 15 , 16 , 17 ]. They also possess pharmacological properties such as anti-inflammatory [ 18 , 19 , 20 ], antimalarial [ 21 , 22 , 23 , 24 , 25 ], anti-cancer [ 26 , 27 , 28 , 29 , 30 , 31 ], anti-hypertension [ 32 ], anti-bacterial [ 33 , 34 , 35 , 36 , 37 ], anti-tubercular [ 38 , 39 , 40 , 41 , 42 , 43 ], anti-fungal [ 33 , 44 , 45 , 46 , 47 ], anti-urease [ 48 ], anti-Alzheimer [ 49 ], anti-diabetic [ 50 ] and anti-oxidant [ 51 , 52 , 53 ]. Quinoline moiety is a vital part of various natural and pharmacologically active compounds exhibiting a wide-range of biological activities [ 54 , 55 , 56 ].…”

Synthesis and Antimicrobial Evaluation of Some Tricyclic Substituted benzo[h]quinazolines, benzo[h]quinolines and naphthaleno[d]thiazoles

“…These pharmacological activities include DNA binding 4 , antitumor [5][6][7] , benzodiazepine and GABA receptor ligand activity 8 , antiviral 9,10 , antibacterial 11 , antituberculosis 12,13 and cellular phosphorylation and tyrosine kinase inhibition 14 . Many marketed drugs comprise quinazoline nucleus in their structures such as; , treatment of lupus 25 , treatment of neurodegenerative diseases 26 , antitubercular 27,28 , antiprotozoal 29,30 and anticancer 31,32 . Among the marketed drugs carrying quinoline nucleus is the fluoroquinolone antibacterial ciprofloxacin.…”

Metal-free domino one-pot protocols for quinoline synthesis

“…In coordination chemistry, quinolines are used to chelate metallic ions as N-donor ligands. 2 The quinoline scaffold has been reported to possess diverse range of pharmacological activities [3][4][5][6][7][8][9][10][11][12][13][14] including antiprotozoal, [15][16][17][18][19][20] antitubercular, 21,22 anticancer, 4,23,24 antipsychotics, 25 antiinammatory, 26,27 antioxidant, 3 anti-HIV, 28 antifungal, 29 as efflux pump inhibitors, 30 and for treatment of neurodegenerative diseases, 19 and treatment of lupus, 31 etc.…”