Quince seed hydrogel (glucuronoxylan): Evaluation of stimuli responsive sustained release oral drug delivery system and biomedical properties

Ashraf, Muhammad; Hussain, Muhammad Ajaz; Bashir, Sajid; Haseeb, Muhammad Tahir; Hussain, Zakir

doi:10.1016/j.jddst.2018.04.008

Cited by 38 publications

(17 citation statements)

References 36 publications

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“…Our results were correlated with the previous study in which more swelling was observed at higher concentration of quince gel due to higher proportion of deprotonation of carboxyl group of polysaccharides at basic or neutral pH. Similarly, the higher swelling behaviour is also associated with the presence of greater number of carboxylate ions in the solution that produces more repulsion [ 32 ]. Such high values of swelling index make quince hydrogel an excellent candidate to be used as binder, disintegrating and matrix agent for sustained release dosage forms [ 41 ].…”

Section: Resultssupporting

confidence: 90%

“…The quince mucilage, a source of high quality nanofibrillar cellulosic materials, has good mechanical properties that make it attractive to build novel bio-materials and composite structures [ 31 ]. A pH responsive swelling behaviour of quince mucilage was observed; significant swelling was observed in a basic media, while insignificant swelling was observed in an acidic media [ 32 ]. Quince-seed mucilage was used as a stabilizer in emulsion preparation and green synthesis of zinc oxide nanoparticles and as a bioabsorbant to remove calcium ions from solution [ 33 – 35 ].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of calcium carbonate-quince bio-composite for programmed and on-demand drug release of paracetamol at target site: a green chemistry approach

et al. 2022

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In this study, an inorganic–organic composite system was developed through biomineralization of calcium carbonate in the quince-seed mucilage-based hydrogel. Drug-polymer interactions were studied by FTIR, DSC, XRD and SEM analysis. The water absorption capacity was calculated by swelling index. Drug release was determined at various pH. Several in vitro kinetic models were applied to observe drug release behaviour. Studies of drug-polymer interactions and particle flow characteristics of the developed composite material have shown that there is good compatibility between drug and the excipients. The XRD and SEM results confirmed calcite polymorphs in the developed composite material. Thermograms showed that the developed composite material was heat stable. A restricted drug release was observed in an acidic medium (pH 1.2). A controlled drug release was depicted from the developed system at pH 6.8. The drug release mechanism of Super Case II was suggested. The developed system was considered to be an effective drug carrier for colon targeted oral delivery of non-steroidal anti-inflammatory drugs (NSAIDs) to avoid gastric irritation and risk of ulceration. Graphical abstract An illustration of extraction of quince hydrogel and development of calcium carbonate-quince (CaCO 3 -Q) composite system; QSM = Quince seed mucilage Supplementary Information The online version contains supplementary material available at 10.1007/s00289-022-04400-1.

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Section: Resultssupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Synthesis of calcium carbonate-quince bio-composite for programmed and on-demand drug release of paracetamol at target site: a green chemistry approach

et al. 2022

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“…The value of was found from 1.295-1.402 indicating a super case-II transport, i.e., erosion-based drug release [42]. during blood-hydrogel interaction and compared to the control [43]. The weight of the clot formed and thrombose (%) was found to be 0.41 ± 0.03 g and 92.11 ± 2.18%, respectively (Table 4).…”

Section: In Vitro Drug Release Study and Mechanismmentioning

confidence: 94%

Polysaccharide-Based Superporous, Superabsorbent, and Stimuli Responsive Hydrogel from Sweet Basil: A Novel Material for Sustained Drug Release

Lodhi

Hussain

Sher

et al. 2019

Advances in Polymer Technology

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This study is carried out on polysaccharide-based hydrogel extracted from the seeds of Ocimum basilicum L. for its evaluation as a superabsorbent and stimuli responsive biomaterial for sustained release drug delivery system. O. basilicum (Syn: Basil) seed hydrogel (BSH) expressed high swelling capacity at pH 6.8 and 7.4 and deionized water. Highly reversible on-off switching (swellingdeswelling) behavior of BSH was ascertained in deionized water and ethanol, pH 7.4 and 1.2, and deionized water and normal saline. Scanning electron microscopy (SEM) of BSH has revealed macroporous structure of BSH having average pore size of 1.92 ± 3.83 m noted after swelling and lyophilization. BSH containing tablet formulations showed a sustained release pattern of diclofenac sodium (DS) which is dependent on the concentration of BSH. When comparing with commercially available formulation of DS, even better sustained release behavior of DS was observed in BSH-based formulation. Super case-II transport mechanism is followed by the DS release from BSH matrix tablet. Haemocompatibility studies of BSH were also performed and found it nonhaemolytic and nonthrombogenic. Recently, polysaccharide-based hydrogels have gained a lot of interest in drug delivery system due to their extraordinary swelling indices, stimuli responsive properties, biodegradability, biocompatibility, and nontoxicity [9][10][11][12][13].Ocimum basilicum L., (Syn: sweet basil in English, Babui tulsi in Hindi and Marathi, Rihan in Arabic, Niasabo in Gujrati, Jangli tulsi in Urdu, Tohrakhurasani in Persian, and Okimon in Unani) is a popular culinary and ornamental herb

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“…Swelling Studies. The swelling ratio (dynamic swelling) of copolymers was performed up to 72 h, and equilibrium swelling of copolymers was continued for 2-3 weeks until a constant weight was achieved in 100 mL buffer solutions of different pH, respectively [25,26]. Dynamic and equilibrium swelling was calculated from the following formulas:…”

Section: Synthesis Of Artemisia Vulgaris-aammentioning

confidence: 99%

Formulation, In Vitro Evaluation, and Toxicity Studies of A. vulgaris-co-AAm Carrier for Vildagliptin

Kausar

Erum

Tulain

et al. 2021

Advances in Polymer Technology

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This study investigated the use of Artemisia vulgaris L. seed mucilage as a new excipient for sustained delivery of Vildagliptin. Copolymeric carrier of A. vulgaris seed mucilage-co-AAm was devised by using acrylamide (AAm) as a monomer, methylene-bis-acrylamide (MBA) as a crosslinker, and potassium persulfate (KPS) as an initiator through free radical polymerization. Different formulations of A. vulgaris-co-AAm were devised by varying contents of polymer, monomer, crosslinking agent, initiator, and reaction temperature. Copolymeric structures were characterized through XRD analysis, Fourier transform infrared (FTIR) spectroscopy, TGA and DSC analysis, and scanning electron microscopy. Porosity, gel fraction, and Vildagliptin loading capacity of copolymers were also established. Swelling and in vitro drug release studies were conducted. XRD evaluation showed the alteration of the crystalline structure of Vildagliptin into an amorphous form. FTIR analysis confirmed the successful grafting of AAm to A. vulgaris seed mucilage backbone. Porosity was increased with increasing polymer concentration and reaction temperature while it was decreased with an increasing amount of AAm, MBA, and KPS. Gel content was decreased with increasing polymer concentration and reaction temperature while it was increased with an increasing amount of AAm, MBA, and KPS. Acute oral toxicity of copolymeric network was done in animal models to evaluate the safety. Copolymers showed the same swelling behavior at all pH 1.2, 4.5, 6.8, and 7.4. Vildagliptin release from copolymer showed a cumulative trend by increasing polymer content and reaction temperature, while a declining trend was observed with increasing contents of monomer, crosslinking agent, and initiator. Sustained release of Vildagliptin was observed from copolymers and release followed the Korsmeyer-Peppas model. From the acute oral toxicity studies, it is evident that newly synthesized copolymeric carriers are potentially safe for eyes, skin, and vital organs.

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Quince seed hydrogel (glucuronoxylan): Evaluation of stimuli responsive sustained release oral drug delivery system and biomedical properties

Cited by 38 publications

References 36 publications

Synthesis of calcium carbonate-quince bio-composite for programmed and on-demand drug release of paracetamol at target site: a green chemistry approach

Synthesis of calcium carbonate-quince bio-composite for programmed and on-demand drug release of paracetamol at target site: a green chemistry approach

Polysaccharide-Based Superporous, Superabsorbent, and Stimuli Responsive Hydrogel from Sweet Basil: A Novel Material for Sustained Drug Release

Formulation, In Vitro Evaluation, and Toxicity Studies of A. vulgaris-co-AAm Carrier for Vildagliptin

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