Quick and selective extraction of<i>Z</i>-ligustilide from<i>Angelica sinensis</i>using magnetic multiwalled carbon nanotubes

Zeng, Qiong; Jia, Yanwei; Xu, Pei-Li; Xiao, Meng-Wei; Liu, Yiming; Peng, Shu‐Lin; Liao, Xun

doi:10.1002/jssc.201500862

Cited by 20 publications

(14 citation statements)

References 33 publications

(44 reference statements)

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“…Furthermore, Radix Angelica sinensis is regularly taken by almost half of tamoxifen-treated breast cancer survivors [23]. Z-ligustilide (Z-LIG) is a representative phthalide compound and accounts for more than 50% in the volatile oil of Radix Angelica sinensis [24]. Recently, Z-LIG was shown to exert inhibitory effect on a variety of human tumors, including colorectal cancer [25] and prostate cancer [26], leukemia [27] and brain tumor [28].…”

Section: Introductionmentioning

confidence: 99%

Sensitization of tamoxifen-resistant breast cancer cells by Z-ligustilide through inhibiting autophagy and accumulating DNA damages

Jiang

Wang

et al. 2017

Oncotarget

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Autophagy plays a pro-survival role in the tamoxifen-resistant breast cancer cells. Herein we found that autophagy was concomitantly induced in tamoxifen-resistant MCF-7 (MCF-7TR5) cells through the dissociation of Bcl-2 from Beclin 1 and subsequent enhancement of interaction among the ATG14-Beclin1-PI3KC3 complex. Moreover, higher level of DNA damage was observed in MCF-7TR5 cells with the decreased BRCA1 and RAD51 level and the increased Ku80 level. Interestingly, Nur77 was selectively degraded by autophagy, which causes the release of Ku80 from the Nur77-Ku80 complex, resulting in the increase of the DNA binding of Ku80 and DNA-PKcs. Meanwhile, Z-ligustilide, a phthalide compound from Radix Angelica sinensis, was shown to inhibit the autophagic flux by blocking the autophagosome-lysosome fusion. Importantly, Z-ligustilide-mediated autophagy inhibition restored Nur77 expression in MCF-7TR5 cells. Furthermore, Z-ligustilide promoted the interaction of Nur77 with Ku80 and thereby abolished the association of DNA-PKcs with DNA ends. Moreover, Z-ligustilide sensitized MCF-7TR5 cells in a caspase-independent cell death and enhanced the DNA damage caused by tamoxifen, which was found to be attenuated by shNur77. Together, these findings not only provide important insights into the formation of tamoxifen resistance in breast cancer cells, but also suggest Z-ligustilide may function as a novel autophagy inhibitor to overcome chemoresistance.

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Section: Introductionmentioning

confidence: 99%

Sensitization of tamoxifen-resistant breast cancer cells by Z-ligustilide through inhibiting autophagy and accumulating DNA damages

Jiang

Wang

et al. 2017

Oncotarget

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“…In the cyclic voltammetry (CV), the immobilization of nano‐composite on electrodes usually results in a change of current response; therefore, CV has usually been used to characterize the nano‐composite . In this work, the cyclic voltammograms of mCNTs and PD‐mCNTs were measured in phosphate buffer (PBS) (pH 7) containing 0.1 M KCl and 5 mM potassium ferricyanide.…”

Section: Resultsmentioning

confidence: 99%

“…Supporting electrolyte: pH 7 PBS containing 5 mM FeCN(K 3 Fe(CN) 6 ) and 0.1 M KCl; scan rate: 50 mV/s. Carbon rings served as the working and counter electrodes, Ag/AgCl reference electrode current response; therefore, CV has usually been used to characterize the nano-composite [40,41]. In this work, the cyclic voltammograms of mCNTs and PD-mCNTs were measured in phosphate buffer (PBS) (pH 7) containing 0.1 M KCl and 5 mM potassium ferricyanide.…”

Section: F I G U R E 3 (A) the Image Of Pd-mcnts (Left) And Mcnts (Rimentioning

confidence: 99%

Extraction of ochratoxin A in red wine with dopamine‐coated magnetic multi‐walled carbon nanotubes

Wan

Zhang

Bai

et al. 2017

J of Separation Science

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A new, rapid, green, and cost-effective magnetic solid-phase extraction of ochratoxin A from red wine samples was developed using polydopamine-coated magnetic multi-walled carbon nanotubes as the absorbent. The polydopamine-coated magnetic multi-walled carbon nanotubes were fabricated with magnetic multi-walled carbon nanotubes and dopamine by an in situ oxidative self-polymerization approach. Transmission electron microscopy, dynamic light scattering, X-ray photoelectron spectroscopy and vibrating sample magnetometry were used to characterize the absorbents. Ochratoxin A was quantified with high-performance liquid chromatography coupled with fluorescence detection, with excitation and emission wavelengths of 338 and 455 nm, respectively. The conditions affecting the magnetic solid-phase extraction procedure, such as pH, extraction solution, extraction time, absorbent amount, desorption solution and desorption time were investigated to obtain the optimal extraction conditions. Under the optimized conditions, the extraction recovery was 91.8-104.5% for ochratoxin A. A linear calibration curve was obtained in the range of 0.1-2.0 ng/mL. The limit of detection was 0.07 ng/mL, and the limit of quantitation was 0.21 ng/mL. The recoveries of ochratoxin A for spiked red wine sample ranged from 95.65 to 100.65% with relative standard deviation less than 8%. The polydopamine-coated magnetic multi-walled carbon nanotubes showed a high affinity toward ochratoxin A, allowing selective extraction and quantification of ochratoxin A from complex sample matrixes.

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“…The magnetic nanoparticles were synthesized based on a previous report using some modifications . The FeCl 3 ·6H 2 O (10 g) was dissolved in 200 mL of ethylene glycol, then 716 mg multiwalled carbon nanotubes were added into the solution, and sonicated (200 W, 40 Hz) for 30 min.…”

Section: Methodsmentioning

confidence: 99%

Magnetic solid‐phase extraction for determination of the total malachite green, gentian violet and leucomalachite green, leucogentian violet in aquaculture water by high‐performance liquid chromatography with fluorescence detection

Zhao

Wei

Yang

2016

J of Separation Science

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In this study, magnetic multi-walled carbon nanotube nanoparticles were synthesized and used as the adsorbent for the sums of malachite green, gentian violet and leucomalachite green, leucogentian violet in aquaculture water samples followed by high performance liquid chromatography with fluorescence detection. This method was based on in situ reduction of chromic malachite green, gentian violet to colorless leucomalachite green, leucogentian violet with potassium borohydride, respectively. The obtained adsorbent combines the advantages of carbon nanotubes and Fe3 O4 nanoparticles in one material for separation and preconcentration of the reductive dyes in aqueous media. The structure and properties of the prepared nanoparticles were characterized by transmission and scanning electron microscopy, X-ray diffraction, and Fourier-transform infrared spectroscopy. The main parameters affecting the adsorption recoveries were investigated and optimized, including reducing agent concentration, type and amount of sorbent, sample pH, and eluting conditions. Under the optimum conditions, the limits of detection in this method were 0.22 and 0.09 ng/mL for malachite green and gentian violet, respectively. Product recoveries ranged from 87.0 to 92.8% with relative standard deviations from 4.6 to 5.9%. The results indicate that the sorbent is a suitable material for the removal and concentration of triphenylmethane dyes from polluted environmental samples.

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Quick and selective extraction ofZ-ligustilide fromAngelica sinensisusing magnetic multiwalled carbon nanotubes

Cited by 20 publications

References 33 publications

Sensitization of tamoxifen-resistant breast cancer cells by Z-ligustilide through inhibiting autophagy and accumulating DNA damages

Sensitization of tamoxifen-resistant breast cancer cells by Z-ligustilide through inhibiting autophagy and accumulating DNA damages

Extraction of ochratoxin A in red wine with dopamine‐coated magnetic multi‐walled carbon nanotubes

Magnetic solid‐phase extraction for determination of the total malachite green, gentian violet and leucomalachite green, leucogentian violet in aquaculture water by high‐performance liquid chromatography with fluorescence detection

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