Quetiapine as a first-choice agent in subjects at high-risk to psychosis?

Outreach and support in South London (OASIS), 2001–2011: Ten years of early diagnosis and treatment for young individuals at high clinical risk for psychosis

“…Repeated psychometric measures and discussion with the clinical team are used to map the response to the treatment and the needs of the patients. Most of the OASIS clients (63%) did receive some CBT: as single first-line therapy (33%) or in co-therapy with antidepressants (11%) [25] or antipsychotics (19%) [56] (Table 2). Low-dosages antipsychotics, more frequently Quetiapine 25-200 mg are allowed when patients complained of persistent attenuated psychotic symptoms impacting their overall functioning and subjective quality of life.…”

Are we really mapping psychosis risk? Neuroanatomical signature of affective disorders in subjects at ultra high risk

“…Given that antipsychotics and antidepressants in addition to psychological interventions can prevent the onset of psychosis (Fusar-Poli et al 2007), the longitudinal results of our cohort do not represent the natural history of the UHR state. Furthermore, treatments for the UHR state are commonly non-specific and may target depression and anxiety and not only attenuated symptoms (O'Connor et al 2007). This model is further supported by recent meta-analytical evidence indicating that ACC structure is particularly sensitive to antipsychotic treatment during the early phases of psychosis (Radua et al 2012).…”