Quercitrin, a glycoside form of quercetin, prevents lipid peroxidation in vitro

Wagner, Caroline; Fachinetto, Roselei; Corte, Cristiane Lenz Dalla; Brito, Verônica Bidinotto; Severo, Diego Fernandes Dias; Dias, Gilvan de Oliveira Costa; Morel, Ademir F.; Nogueira, Cristina W.; Rocha, João Batista Teixeira da

doi:10.1016/j.brainres.2006.05.084

Cited by 94 publications

(52 citation statements)

References 70 publications

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“…The composition of flavonols in genus Allium varies widely depending on the growing conditions and storage (10). Previous animal studies have revealed that quercetin enhanced the antioxidant levels in the plasma (11)(12)(13)(14). Quercetin derivatives have been used in the treatment of peroxynitrite-oxidized sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (15).…”

Section: Introductionmentioning

confidence: 99%

“…Quercetin derivatives have been used in the treatment of peroxynitrite-oxidized sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (15). In addition, the quercetin glucosides are more effectively absorbed than quercetin aglycone in humans (11,16). The difference in absorption rate was attributed to glycosylation in quercetin metabolism.…”

Section: Introductionmentioning

confidence: 99%

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Effect of quercetin glucosides from Allium extracts on HepG2, PC‑3 and HT‑29 cancer cell lines

Pan

Zheng

2018

Oncol Lett

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of quercetin glucosides from Allium extracts on HepG2, PC‑3 and HT‑29 cancer cell lines

Pan

Zheng

2018

Oncol Lett

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“…Recently, Compound 7, quercetin-3-O-α-L-rhamnopyranoside was reported the protective effect against hydrogen peroxideinduced dysfunction in osteoblastic MC3T3-E1 cells (Choi, 2010), and lipid peroxidation (Wagner et al, 2006). It was reported that compound 3, quercetin has protective effects on rat liver against lead-induced oxidative stress and apoptosis, and kidney against oxidative stress-mediated DNA damage and apoptosis induced by lead (Liu et al, 2010a;2010b).…”

Section: Resultsmentioning

confidence: 99%

Antioxidative Constituents of the Aerial Parts of Galium spurium

Yang¹,

Park²,

Ahn³

et al. 2011

Biomolecules and Therapeutics

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Reactive oxygen species (ROS), in the form of superoxide anion(O 2 − ), hydroxyl radical (·OH) and hydrogen peroxide (H 2 O 2 ), are generated in living organisms through many pathways (Chung et al., 2005). An imbalance between production of ROS and their elimination in the organisms cause oxidative stress (Monika et al., 2010). Oxidative stress has been implicated as a possible factor in the etiology of several human diseases, including cancer, cardiovascular disease, Alzheimer's disease and aging (Suganya et al., 2007). Antioxidants are the important defense factors against oxidative stress caused by ROS. However, the use of synthetic antioxidant components, such as butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT), has been limited because of their possible toxic and carcinogenic effects (Branen, 1975). Thus, there is a growing interest in fi nding natural herbal plants with low in toxicity and high in radical scavenging activity (Branen, 1975). In the course of screening for antioxidant from Korean natural plants by measuring the radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH), a total extract of the Galium spurium L. (Rubiaceae) was found to show a potent antioxidant activity. G. spurium is annual or biannual plant. Phytochemical studies on the genus have shown it to be chemically diverse, yielding among others, triterpenoid saponins, iridoidAs part of an ongoing search for natural plants with antioxidant compounds by measuring the radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH), a total extract of the twigs of Galium spurium L. (Rubiaceae) was found to show potent antioxidant activity. Subsequent activity-guided fractionation of the methanolic extract led to the isolation of nine compounds, asperulosidic acid methyl ester (1), asperuloside (2), caffeic acid ( (8), and quercetin (9). Their structures were elucidated by spectroscopic studies. Compounds 1, 3-8 were isolated for the fi rst time from this plant. Among them, compounds 3 and 9 showed the signifi cant radical scavenging effects on DPPH, and compounds 3 and 7 showed the potent ribofl avin originated superoxide quenching activities. et al., 2000). Some iridoids (Deliorman et al., 2001), anthraquinones (Koyama et al., 1993) and fl avonoids (Cai et al., 2009) were analyzed from G. spurium. Its aerial parts have been used for the treatment of the bones and sinews pain and hematuria. Crude extract of G. spurium was also used as a anticancer agent in folk medicine. It has been reported to have immunostimulant and anti-tumor activity (Yoon et al., 2005). However, information concerning the antioxidant activity of G. spurium is unavailable. This paper deals with the isolation and structural characterization of these compounds and their scavenging activity of the stable DPPH free radical and superoxide quenching activities.

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“…On the other hand, quercetin and its derivatives in the body can selectively inhibit NMDA receptor functionality [in some ways acting as an antagonist] [34] and in this way exert their beneficial effect in some animal model of neural diseases like Parkinson's disease (PD).…”

Section: Discussionmentioning

confidence: 99%

Behavioral Studies of Wistar Rats in Rotenone Induced Model of Parkinson’s Disease

Priyanga

Krishnamurthy

Selvaraj

2017

Int J Pharm Pharm Sci

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Objective: The objective of the study was to determine the behavioral activities of Wistar rats induced with rotenone.Methods: Thirty-six male Wistar rats were taken for the study and divided into six groups of six rats each. Group-I is the vehicle-treated, Group-II animals were induced with rotenone (3 mg/kg/bwt) by i. p. Group-III were co-treated with rotenone and L-DOPA (10 mg/kg/bwt) orally, Group-IV were co-treated with rotenone and quercetin (25 mg/kg/bwt) orally, Group-V were co-treated with rotenone and hesperidin (50 mg/kg/bwt) orally, Group-VI were treated with rotenone, quercetin and hesperidin in the same dosage regime for 60 d. The behavioural tests, such as open field test, ladder climbing test and hanging wire test were performed. The biochemical parameters such as urea, creatinine and activities of ALT and AST were also analysed.Results: All data are expressed as the mean±SD. Disability was noted in the behaviour of rats induced with Parkinson's disease (PD). The deficits in behavioral activity were significantly changed when compared with an induced group (p<0.001) and biochemical parameters due to rotenone were significantly (p<0.001) restored by co-treatment with quercetin and hesperidin. Conclusion:In our in vivo study, we have demonstrated the combination of quercetin and hesperidin to serve as neuroprotective compounds by improving the behavioral abnormalities and restoring the biochemical parameters. Hence, these powerful antioxidants may protect brain cells.

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Quercitrin, a glycoside form of quercetin, prevents lipid peroxidation in vitro

Cited by 94 publications

References 70 publications

Effect of quercetin glucosides from Allium extracts on HepG2, PC‑3 and HT‑29 cancer cell lines

Effect of quercetin glucosides from Allium extracts on HepG2, PC‑3 and HT‑29 cancer cell lines

Antioxidative Constituents of the Aerial Parts of Galium spurium

Behavioral Studies of Wistar Rats in Rotenone Induced Model of Parkinson’s Disease

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