Quercetin-rich onion peel extract suppresses adipogenesis by down-regulating adipogenic transcription factors and gene expression in 3T3-L1 adipocytes

Bae, Cho-Rong; Park, Yun-Kyung; Cha, Youn‐Soo

doi:10.1002/jsfa.6604

Cited by 57 publications

(42 citation statements)

References 42 publications

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“…Flavonoids are found in onions, with notable bioactivity (1,2). These plant-derived polyphenols serve beneficial roles in humans (3,4) and contain chemical substances that irritate the eyes (1). Certain phenolic compounds and flavonoids exhibit anti-inflammatory, anti-cholesterol, anticancer and antioxidant properties (1)(2)(3)(4).…”

Section: Introductionmentioning

confidence: 99%

“…These plant-derived polyphenols serve beneficial roles in humans (3,4) and contain chemical substances that irritate the eyes (1). Certain phenolic compounds and flavonoids exhibit anti-inflammatory, anti-cholesterol, anticancer and antioxidant properties (1)(2)(3)(4). These plant-derived phytochemical flavonols include quercetins (3,5) and quercetin glycosides (6,7).…”

Section: Introductionmentioning

confidence: 99%

“…Certain phenolic compounds and flavonoids exhibit anti-inflammatory, anti-cholesterol, anticancer and antioxidant properties (1)(2)(3)(4). These plant-derived phytochemical flavonols include quercetins (3,5) and quercetin glycosides (6,7). Quercetins have been reported to exhibit anticancer and anti-inflammatory activities (8,9).…”

Section: Introductionmentioning

confidence: 99%

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Effect of quercetin glucosides from Allium extracts on HepG2, PC‑3 and HT‑29 cancer cell lines

Pan

Zheng

2018

Oncol Lett

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of quercetin glucosides from Allium extracts on HepG2, PC‑3 and HT‑29 cancer cell lines

Pan

Zheng

2018

Oncol Lett

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“…In 3T3-L1 cells, quercetin and quercetin-rich OPE attenuated adipogenesis [1718] and decreased liver fat accumulation in mice fed a Western diet or high-fat diet (HFD) [79]. Recently, Yang and Kim [19] demonstrated that the obesity index (% fat, BMI, waist circumstance) were significantly decreased by OPE intake for 12 weeks in obese university women.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Onion Peel Extract on Inflammatory Mediators in Korean Overweight and Obese Women

Kim

Yim

2016

Clin Nutr Res

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Quercetin, found abundantly in onion peel, has been known to have antioxidant and anti-obesity effects and improves endothelial function. The purpose of this study was to evaluate the effects of a quercetin-rich onion peel extract (OPE) on the inflammatory mediators in overweight and obese women. This study was a randomized double-blind, placebo-controlled study. Thirty-seven healthy overweight and obese women were randomly assigned to two groups, and one group was given a soft capsuled OPE (100 mg quercetin/day, n = 18) and the other group a same capsuled placebo (n = 19) for 12 weeks. Fat mass was measured by bioimpendance method at baseline and after 12 weeks of intervention. The levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured with colorimetric assay kits. The concentrations of leptin, adiponectin, visfatin, tumor necrosis factor (TNF)-α and interleukin (IL)-4 in plasma were determined by using enzyme-linked immunosorbent assay kits. Baseline characteristics of anthropometric indicators and blood metabolic profiles were not significantly different between placebo and OPE groups. Compared with baseline value, both placebo and OPE supplementation significantly decreased the percent of body fat mass and induced plasma adiponectin levels while ALT and AST activities as well as leptin, visfatin, TNF-α, and IL-4 levels in plasma were not significantly different between two groups after 12 weeks of the supplementation. These findings suggest that 12-week supplementation of OPE do not affect modulators of systemic inflammation in overweight and obese women.

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“…Onion (Allium cepa L.) is a universally consumed functional food rich in flavonoids, mainly quercetin and saponins (9), which suppress oxidative stress and inflammation as well as induce lipolysis (10). More than 500,000 tons of onion peel waste is produced annually in the European Union and other parts of the world.…”

Section: Introductionmentioning

confidence: 99%

Hypocholesterolemic effect of quercetin-rich onion peel extract in C57BL/6J mice fed with high cholesterol diet

Kang

Pichiah

Abinaya

et al. 2016

Food Sci Biotechnol

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Onion peel (OP) extract is known as a rich source of flavonoids, mainly quercetin. We hypothesized that OP has hypocholesterolemic effects. To investigate the effect of OP, C57BL/6J mice were divided into 4 dietary groups (=10); normal diet (ND); high cholesterol diet (HC); and high cholesterol diet with 100 or 200 mg OP extract (OP-100 or OP-200, respectively) per kg of body weight. After 12 weeks, lower values of liver weight, serum total cholesterol levels, LDL cholesterol, atherogenic index, cardiac risk factor, hepatic triacylglycerol, and total cholesterol, and higher fecal cholesterol levels were observed in the OP-200 than in the HC group. The hepatic mRNA expression levels of low-density lipoprotein receptors (LDL-R) and cholesterol 7-alpha-monooxygenase (CYP7A1) were high in the OP-200 compared to the HC group. These observations suggest that OP promoted lowering of serum and hepatic cholesterol in mice primarily via fecal excretion.

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Quercetin-rich onion peel extract suppresses adipogenesis by down-regulating adipogenic transcription factors and gene expression in 3T3-L1 adipocytes

Abstract: The results indicate that OPE treatment significantly prevents intracellular lipid accumulation via hyperactivation of genes regulating lipolysis as compared with quercetin alone.

Cited by 57 publications

References 42 publications

Effect of quercetin glucosides from Allium extracts on HepG2, PC‑3 and HT‑29 cancer cell lines

Effect of quercetin glucosides from Allium extracts on HepG2, PC‑3 and HT‑29 cancer cell lines

The Effect of Onion Peel Extract on Inflammatory Mediators in Korean Overweight and Obese Women

Hypocholesterolemic effect of quercetin-rich onion peel extract in C57BL/6J mice fed with high cholesterol diet

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