Quercetin regulates vascular endothelium function in chronic renal failure via modulation of Eph/Cav‐1 signaling

Chen, Jing; Zhang, Huaming; Yang, Yanbo; Chen, Bo

doi:10.1002/ddr.21940

Cited by 8 publications

(7 citation statements)

References 35 publications

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“…Cav-1 is critical for NO production via inactivating eNOS. Both Cav-1 and eNOS are modulated by PI3K/AKT signaling ( Chen et al, 2021 ; Chen J. et al, 2022 ). To further understand the effector molecules of YBT-induced Cav-1 regulation, we performed immunoblotting and immunohistochemical experiments on PI3K/AKT and eNOS signaling, respectively.…”

Section: Resultsmentioning

confidence: 99%

Yue-bi-tang attenuates adriamycin-induced nephropathy edema through decreasing renal microvascular permeability via inhibition of the Cav-1/ eNOS pathway

Cheng

Lin

et al. 2023

Front. Pharmacol.

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Edema is one of the most typical symptoms of nephrotic syndrome. Increased vascular permeability makes a significant contribution to the progression of edema. Yue-bi-tang (YBT) is a traditional formula with excellent clinical efficacy in the treatment of edema. This study investigated the effect of YBT on renal microvascular hyperpermeability-induced edema in nephrotic syndrome and its mechanism. In our study, the content of target chemical components of YBT was identified using UHPLC-Q-Orbitrap HRMS analysis. A nephrotic syndrome model was replicated based on male Sprague-Dawley rats with Adriamycin (6.5 mg/kg) by tail vein injection. The rats were randomly divided into control, model, prednisone, and YBT (22.2 g/kg, 11.1 g/kg, and 6.6 g/kg) groups. After 14 d of treatment, the severity of renal microvascular permeability, edema, the degree of renal injury, and changes in the Cav-1/eNOS pathway were assessed. We found that YBT could regulate renal microvascular permeability, alleviate edema, and reduce renal function impairment. In the model group, the protein expression of Cav-1 was upregulated, whereas VE-cadherin was downregulated, accompanied by the suppression of p-eNOS expression and activation of the PI3K pathway. Meanwhile, an increased NO level in both serum and kidney tissues was observed, and the above situations were improved with YBT intervention. It thus indicates YBT exerts therapeutic effects on the edema of nephrotic syndrome, as it improves the hyperpermeability of renal microvasculature, and that YBT is engaged in the regulation of Cav-1/eNOS pathway-mediated endothelial function.

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Section: Resultsmentioning

confidence: 99%

Yue-bi-tang attenuates adriamycin-induced nephropathy edema through decreasing renal microvascular permeability via inhibition of the Cav-1/ eNOS pathway

Cheng

Lin

et al. 2023

Front. Pharmacol.

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“…Polyphenols have antioxidant and anti-atherosclerotic properties that inhibit peroxyl radical-induced DNA strand damage, inhibit platelet aggregation, reduce low-density lipoprotein (LDL) oxidation, and improve vascular endothelial function [84]. Resveratrol (RSV), a polyphenol compound found in grapes, red wine, mulberries, white flamingos (Veratrum grandiflorum O. Loes), and Polygonum cuspidatum, has been widely studied for its beneficial effects on human health, including neurological protective effects [85,86], cardioprotective [87], and anti-tumor [88].…”

Section: Discussionmentioning

confidence: 99%

Research Progress on Effects of Ginsenoside Rg2 and Rh1 on Nervous System and Related Mechanisms

Liu,

Chen,

Zhao

et al. 2023

Molecules

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Neurological-related disorders are diseases that affect the body’s neurons or peripheral nerve tissue, such as Parkinson’s disease (PD) and Alzheimer’s disease (AD). The development of neurological disorders can cause serious harm to the quality of life and functioning of the patient. The use of traditional therapeutic agents such as dopamine-promoting drugs, anticholinergic drugs, cholinesterase inhibitors, and NMDA receptor antagonists is often accompanied by a series of side effects such as drug resistance, cardiac arrhythmia, liver function abnormalities, and blurred vision. Therefore, there is an urgent need to find a therapeutic drug with a high safety profile and few side effects. Herbal medicines are rich in active ingredients that are natural macromolecules. Ginsenoside is the main active ingredient of ginseng, which has a variety of pharmacological effects and is considered to have potential value in the treatment of human diseases. Modern pharmacological studies have shown that ginsenosides Rg2 and Rh1 have strong pharmacological activities in the nervous system, with protective effects on nerve cells, improved resistance to neuronal injury, modulation of neural activity, resistance to cerebral ischemia/reperfusion injury, improvement of brain damage after eclampsia hemorrhage, improvement of memory and cognitive deficits, treatment of AD and vascular dementia, alleviation of anxiety, pain, and inhibition of ionic-like behavior. In this article, we searched the pharmacological research literature of Rg2 and Rh1 in the field of neurological diseases, summarized the latest research progress of the two ginsenosides, and reviewed the pharmacological effects and mechanisms of Rg2 and Rh1, which provided a new way of thinking for the research of the active ingredients in ginseng anti-neurological diseases and the development of new drugs.

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“…Quercetin exerts gastroprotective activity against TNF‐α‐induced injury to the gastric mucosal epithelium 10 . Quercetin regulates vascular endothelium function in chronic renal failure via modulation of Eph/Cav‐1 signaling 11 . The antioxidant properties of quercetin have been widely reported in vivo and in vitro.…”

Section: Introductionmentioning

confidence: 99%

“… 10 Quercetin regulates vascular endothelium function in chronic renal failure via modulation of Eph/Cav‐1 signaling. 11 The antioxidant properties of quercetin have been widely reported in vivo and in vitro. Free radical scavenging activity of quercetin protects from various age‐associated disorders.…”

Section: Introductionmentioning

confidence: 99%

Quercetin attenuates inflammation in LPS‐induced lung epithelial cells via the Nrf2 signaling pathway

Lv,

Han,

Cui

et al. 2024

Immunity Inflam & Disease

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BackgroundPneumonia is the leading cause of death among children under five, and kill almost two million children each year. Quercetin, a flavonoid polyphenolic compound, exerts many beneficial biological activities, including anti‐inflammatory functions. Our study aimed to investigate the possibility of quercetin as a therapeutic agent for pneumonia and its role in the inflammatory response induced by lipopolysaccharide (LPS).MethodsLPS induced human alveolar epithelial cell A549 as a lung inflammation model in vitro. The effects of quercetin on the production of cytokines and the expression of related‐proteins were detected by Enzyme‐Linked ImmunoSorbent Assay and Western Blot, respectively. Cell Counting Kit‐8 assay was used to detect cell viability. flow cytometry was used to measure cell apoptosis. NO levels were also analyzed through NO kit.ResultsOur results found that quercetin attenuated the release of IL‐1β, IL‐6, PGE2, and nitrite in LPS‐induced A549 cells. In addition, quercetin inhibits cell apoptosis and relieves ROS generation in LPS‐induced A549 cells. Quercetin also inhibits LPS‐induced NF‐κB activation. They have upregulated the expression of nuclear factor erythroid 2 (Nrf2) and HO‐1.ConclusionIn conclusion, these results suggested that quercetin attenuates LPS‐induced inflammation in A549 by activating the Nrf2 signaling pathway.

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Quercetin regulates vascular endothelium function in chronic renal failure via modulation of Eph/Cav‐1 signaling

Cited by 8 publications

References 35 publications

Yue-bi-tang attenuates adriamycin-induced nephropathy edema through decreasing renal microvascular permeability via inhibition of the Cav-1/ eNOS pathway

Yue-bi-tang attenuates adriamycin-induced nephropathy edema through decreasing renal microvascular permeability via inhibition of the Cav-1/ eNOS pathway

Research Progress on Effects of Ginsenoside Rg2 and Rh1 on Nervous System and Related Mechanisms

Quercetin attenuates inflammation in LPS‐induced lung epithelial cells via the Nrf2 signaling pathway

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