“…Therefore, when PQ is absorbed into the bloodstream, it directly causes damage to vascular endothelial cells. It has been demonstrated that PQ exposure induces glutathione redox cycle dysfunction and excessive endothelial albumin permeability in microvascular endothelial cells ( 6 , 7 ). Therefore, identification of therapeutic agents that can maintain the endothelial barrier and attenuate pulmonary microvascular permeability may reduce mortality and improve prognosis, which is of great significance for the clinical treatment of PQ-induced acute lung injury (ALI), but its protective mechanism needs further study.…”