Quercetin-PVP K25 solid dispersions

Costa, Ana Rita de Mello; Marquiafável, Flávia Silva; Vaz, Mirela Mara de Oliveira Lima Leite; Rocha, Bruno Alves; Bueno, Paula Carolina Pires; Amaral, Pedro Luiz M.; Barud, Hernane da Silva; Berreta-Silva, Andresa Ap.

doi:10.1007/s10973-010-1083-3

Cited by 42 publications

(10 citation statements)

References 25 publications

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“…For example, the formulation of quercetin to polyvinylpyrrolidone solid dispersions considerably could improve the solubility of quercetin as well as its antioxidant activity [77]. For example, the formulation of quercetin to polyvinylpyrrolidone solid dispersions considerably could improve the solubility of quercetin as well as its antioxidant activity [77].…”

Section: Effects Of Polyphenols On Physical Properties Of Formulationsmentioning

confidence: 99%

“…Some authors report the incorporation of polyphenols into solid carrier, in order to increase the solubility of polyphenols in aqueous media as well as to improve their stability in the topical formulation. For example, the formulation of quercetin to polyvinylpyrrolidone solid dispersions considerably could improve the solubility of quercetin as well as its antioxidant activity [77]. The encapsulation of quercetin in tristearin microparticles using phosphatidylcholine as emulsifier decreased its photodegradation in the topical formulation and considerably improved the storage stability [78].…”

Section: Effects Of Polyphenols On Physical Properties Of Formulationsmentioning

confidence: 99%

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Polyphenols as active ingredients for cosmetic products

Zillich

Schweiggert‐Weisz

Eisner

et al. 2015

Intern J of Cosmetic Sci

263

188

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Polyphenols are secondary plant metabolites with antioxidant, anti-inflammatory and anti-microbial activity. They are ubiquitously distributed in the plant kingdom; high amounts contain, for example, green tea and grape seeds. Polyphenolic extracts are attractive ingredients for cosmetics and pharmacy due to their beneficial biological properties. This review summarizes the effects of polyphenols in the context of anti-ageing activity. We have explored in vitro studies, which investigate antioxidant activity, inhibition of dermal proteases and photoprotective activity, mostly studied using dermal fibroblasts or epidermal keratinocytes cell lines. Possible negative effects of polyphenols were also discussed. Further, some physicochemical aspects, namely the possible interactions with emulsifiers and the influence of the cosmetic formulation on the skin delivery, were reported. Finally, few clinical studies, which cover the anti-ageing action of polyphenols on the skin after topical application, were reviewed.

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Section: Effects Of Polyphenols On Physical Properties Of Formulationsmentioning

confidence: 99%

Section: Effects Of Polyphenols On Physical Properties Of Formulationsmentioning

confidence: 99%

Polyphenols as active ingredients for cosmetic products

Zillich

Schweiggert‐Weisz

Eisner

et al. 2015

Intern J of Cosmetic Sci

263

188

View full text Add to dashboard Cite

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“…According to the TG and DSC curves of the IVS320-polymer systems, the materials obtained have a stable thermal profile, showing that the presence of IVS320 does not interfere with the thermal profile of the polymeric carriers, which is behavior that strongly suggests a good interface between compound and polymers [37].…”

Section: Thermogravimetric Analysis (Tg)mentioning

confidence: 94%

Novel Solid Dispersions of Naphthoquinone Using Different Polymers for Improvement of Antichagasic Activity

et al. 2020

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IVS320 (3a,10b-dihydro-1H-cyclopenta[b]naphtho[2,3-d]furan-5,10-dione) is a naphthoquinone that has low solubility in aqueous medium, a physical behavior that limits its biological activities, considering that compounds from this class have several activities. In this work, solid dispersions (SDs) prepared between IVS320 and polymers hydroxypropyl methylcellulose (HPMC), polyethylene glycol (PEG), and polyvinylpyrrolidone (PVP) were developed using physical mixture (PM), kneading (KN), and rotary evaporation (RE) methods. Dispersions were investigated using Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetry (TG), powder X-ray diffraction (PXRD), and scanning electron microscopy (SEM). In addition, in vitro antiparasitic activity in Trypanosoma cruzi Y strains was evaluated. Physical-chemical characterization demonstrated the formation of SDs through the interaction of IVS320 with polymeric matrices. SDs of IVS320-polymer presented a significant potentiation of antichagasic activity, with inhibitory growth around 62% (IVS320-HPMC/RE), 55% (IVS320-PEG/RE), and 85% (IVS320-PVP/RE), while pure IVS320 showed a value of 48% for the highest concentrations evaluated (50 µg/mL).

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“…As relações utilizadas para a codificação dos fatores encontram-se nas Equações (COSTA et al, 2010;DOWD, 1959). As análises foram realizadas em triplicata.…”

Section: Materiais E Métodosunclassified

Obtenção de produtos a partir das folhas de Copaifera langsdorffii Desf.: otimização da extração e secagem em spray dryer utilizando planejamentos experimentais

Costa-Machado¹

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Agradeço especialmente ao Prof. Dr. Luís Alexandre Pedro de Freitas, pela orientação me possibilitando clareza nos momentos de dúvida juntamente com a concessão de autonomia para direcionar meu trabalho. Agradeço também pela confiança, receptividade e acolhimento ao longo destes 28 meses. Agradeço aos Senhores Antônio Carlos Meda e Manoel Eduardo Tavares Ferreira, diretores da Apis Flora, pela oportunidade concedida e possibilidade de realizar este trabalho. Ao Prof. Dr. Jairo Kenupp Bastos, pela confiança e por me permitir participar de uma das suas brilhantes pesquisas. À Profa. Dra. Simone de Pádua Teixeira e sua equipe, pelo auxílio na identificação e localização da árvore da espécie estudada. À Andresa Ap. Berretta e Silva, pela valiosa contribuição e pelas oportunidades profissionais, além de modelo de entusiasmo e motivação. À Paula Carolina Pires Bueno, minha colega e amiga, pela orientação valiosa, pelos ensinamentos científicos, profissionais e pessoais, pela amizade e felicidade de sua companhia. Ao Bruno mineiro, pela companhia, ajuda e suor (rsrs) para coletar as folhas da árvore, além de sua amizade. À Mirela Vaz, pelo auxílio ao desenvolvimento do método cromatográfico e pela amizade, claro! Ao amigo, Henrique Moretto, por me ensinar as malícias da vida e pela capa maravilhosa desta dissertação. Aos queridos colegas da Apis Flora, por fazerem do local de trabalho um segundo lar e pela ajuda a este trabalho. Aos funcionários da Seção de Pós-Graduação, pela atenção. Aos meus colegas do LADIFARP, pela ajuda, carinho e receptividade. Agradeço ao apoio financeiro concedido pela Apis Flora, FINEP e FAPESP. A todos que me auxiliaram e contribuíram para a realização deste trabalho. i RESUMO Costa-Machado, A. R. M. Obtenção de produtos a partir das folhas de Copaifera langsdorffii Desf.: otimizaçao da extração e secagem por spray dryer utilizando planejamentos experimentais. 2011. 130f. Dissertação (mestrado)

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Quercetin-PVP K25 solid dispersions

Cited by 42 publications

References 25 publications

Polyphenols as active ingredients for cosmetic products

Polyphenols as active ingredients for cosmetic products

Novel Solid Dispersions of Naphthoquinone Using Different Polymers for Improvement of Antichagasic Activity

Obtenção de produtos a partir das folhas de Copaifera langsdorffii Desf.: otimização da extração e secagem em spray dryer utilizando planejamentos experimentais

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