Quercetin Loaded Rifampicin-Floating Microspheres for Improved Stability and In-vitro Drug Release

Abstract

After HIV, tuberculosis (TB) is the world's second most frequent disease. MTB (Mycobacterium tuberculosis) is a major infectious disease that poses a considerable public health issue. Fixed-dose drug combination microspheres appear to be a better option for long-term, regulated medication therapy. The drugs could be given orally once a week to encourage patient compliance. For longterm pharmaceutical therapy, fixed-dose drug combination microspheres appear to be a superior option. Oral administration is the most common and favored mode of pharmaceutical administration. Drug release is modulated throughout the GI tract with oral controlled-release (CR) formulations. Swelling and expanding systems, floating systems, forms of the mucoadhesive systems of high-density dose, and magnetic systems have all been employed. The goal of this study is to develop rifampicin-floating microspheres that will increase gastric retention time. The influence of quercetin on in-vitro drug release has been looked. The efficiency of entrapment was determined to be 76.50 percent. After 8 hours, the percentage buoyancy was observed at 61.50.In gastric media, the microspheres produced displayed extended drug release, indicating that they could be employed for long-term anti-tubercular medicine delivery.

In-silico Prediction of Drug Target, Molecular Modeling, and Docking Study of Potential Inhibitors against Burkholderia pseudomallei

“…The Rg values indicate the rigidity of the protein system and were analyzed during the MD simulation. The data show that the Rg value was very close to the maximum, indicating the system's stability throughout the five ns MD simulation (Pingale & Amrutkar, 2021). Also, there is a decreasing trend in the SASA value was observed.…”

Quercetin in Drug Carriers: Polymer Composite, Physical Characteristics, and In vitro Study

“…The buoyancy percentage was measured to be 61.50% after 8 hours. The microspheres produced in the stomach environment demonstrated extended drug release, indicating great potential application for the prolonged delivery of antitubercular drugs (Pingale and Amrutkar, 2021) . The in vitro test results of using ethyl cellulose as polymers are shown in Table 16.…”

Advanced drug delivery and therapeutic strategies for tuberculosis treatment

“…Floating drug delivery methods are low-density devices that allow the drug to float on top of the stomach juice, boosting retention time and bioavailability. Quercetinloaded RIF floating microspheres were developed to treat TB and maintain RIF release in the stomach, and they were found to be stable after six months [194]. RIF stability can be increased by integrating it into sustained-release microporous floating microspheres and gastric-resistant INH sustained-release microspheres.…”