Quercetin inhibits invasion and angiogenesis of esophageal cancer cells

Liu, Yue; Li, Cai-Li; Xu, Qianqian; Cheng, Dan; Liu, Kedi; Sun, Zequn

doi:10.1016/j.prp.2021.153455

Cited by 34 publications

(10 citation statements)

References 26 publications

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“…Quercetin has shown to either inactivate vascular endothelial growth factor (VEGF) or abrogate JAK2/STAT3 signaling pathway and as a result, the angiogenesis has been inhibited [ 30 , 46 , 47 ]. Additionally, the anti-angiogenic effect of quercetin has been closely linked to the decrease of VEGF-A, MMP2, and MMP9 expression [ 48 ], as well as to the inhibition of both tumor growth and angiogenesis by targeting VEGFR2 regulated by AKT/mTOR/P70S6K signaling pathway [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Quercetin Regulates Key Components of the Cellular Microenvironment during Early Hepatocarcinogenesis

et al. 2022

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Hepatocellular carcinoma (HCC) is a health problem worldwide due to its high mortality rate, and the tumor microenvironment (TME) plays a key role in the HCC progression. The current ineffective therapies to fight the disease still warrant the development of preventive strategies. Quercetin has been shown to have different antitumor activities; however, its effect on TME components in preneoplastic lesions has not been fully investigated yet. Here, we aimed to evaluate the effect of quercetin (10 mg/kg) on TME components during the early stages of HCC progression induced in the rat. Histopathological and immunohistochemical analyses showed that quercetin decreases the size of preneoplastic lesions, glycogen and collagen accumulation, the expression of cancer stem cells and myofibroblasts markers, and that of the transporter ATP binding cassette subfamily C member 3 (ABCC3), a marker of HCC progression and multi-drug resistance. Our results strongly suggest that quercetin has the capability to reduce key components of TME, as well as the expression of ABCC3. Thus, quercetin can be an alternative treatment for inhibiting the growth of early HCC tumors.

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Section: Discussionmentioning

confidence: 99%

Quercetin Regulates Key Components of the Cellular Microenvironment during Early Hepatocarcinogenesis

et al. 2022

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“…Yue Liu et al evaluated the effects of quercetin on the angiogenesis and migration of esophageal cancer cells, in addition to the underlying mechanism ( Liu et al, 2021 ). In their study, human esophageal cancer cells (Eca109) received 5 or 10 μg/ml of quercetin.…”

Section: Quercetin and Gastrointestinal Cancermentioning

confidence: 99%

“…Tube formation ability and migration of endothelial cells was inhibited in cells incubated in Eca109 conditioned medium. The group treated with 10 μg/ml quercetin showed reduced levels of MMP2, MMP9, and VEGF-A ( Liu et al, 2021 ). Table 4 lists some studies on the therapeutic effects of quercetin in esophageal cancer.…”

Section: Quercetin and Gastrointestinal Cancermentioning

confidence: 99%

Application of Quercetin in the Treatment of Gastrointestinal Cancers

et al. 2022

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Many cellular signaling pathways contribute to the regulation of cell proliferation, division, motility, and apoptosis. Deregulation of these pathways contributes to tumor cell initiation and tumor progression. Lately, significant attention has been focused on the use of natural products as a promising strategy in cancer treatment. Quercetin is a natural flavonol compound widely present in commonly consumed foods. Quercetin has shown significant inhibitory effects on tumor progression via various mechanisms of action. These include stimulating cell cycle arrest or/and apoptosis as well as its antioxidant properties. Herein, we summarize the therapeutic effects of quercetin in gastrointestinal cancers (pancreatic, gastric, colorectal, esophageal, hepatocellular, and oral).

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“…Quercetin is a well-known antioxidant flavonoid that has antitumor effects [109]. Quercetin induces autophagy in different cancer cells through the modulation of the AKT-mTOR signal pathway [110].…”

Section: Quercetinmentioning

confidence: 99%

Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer

Al-Bari

Ito

Ahmed

et al. 2021

IJMS

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Macro-autophagy (autophagy) is a highly conserved eukaryotic intracellular process of self-digestion caused by lysosomes on demand, which is upregulated as a survival strategy upon exposure to various stressors, such as metabolic insults, cytotoxic drugs, and alcohol abuse. Paradoxically, autophagy dysfunction also contributes to cancer and aging. It is well known that regulating autophagy by targeting specific regulatory molecules in its machinery can modulate multiple disease processes. Therefore, autophagy represents a significant pharmacological target for drug development and therapeutic interventions in various diseases, including cancers. According to the framework of autophagy, the suppression or induction of autophagy can exert therapeutic properties through the promotion of cell death or cell survival, which are the two main events targeted by cancer therapies. Remarkably, natural products have attracted attention in the anticancer drug discovery field, because they are biologically friendly and have potential therapeutic effects. In this review, we summarize the up-to-date knowledge regarding natural products that can modulate autophagy in various cancers. These findings will provide a new position to exploit more natural compounds as potential novel anticancer drugs and will lead to a better understanding of molecular pathways by targeting the various autophagy stages of upcoming cancer therapeutics.

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Quercetin inhibits invasion and angiogenesis of esophageal cancer cells

Cited by 34 publications

References 26 publications

Quercetin Regulates Key Components of the Cellular Microenvironment during Early Hepatocarcinogenesis

Quercetin Regulates Key Components of the Cellular Microenvironment during Early Hepatocarcinogenesis

Application of Quercetin in the Treatment of Gastrointestinal Cancers

Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer

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