Application of Quercetin in the Treatment of Gastrointestinal Cancers

Mirazimi, Seyed Mohammad Ali; Dashti, Fatemeh; Tobeiha, Mohammad; Shahini, Ali; Jafari, Raha; Khoddami, Mehrad; Sheida, Amirhossein; EsnaAshari, Parastoo; Aflatoonian, Amir Hossein; Elikaii, Fateme; Zakeri, Melika Sadat; Hamblin, Michael R.; Aghajani, Mohammad; Bavarsadkarimi, Minoodokht; Mirzaei, Hamed

doi:10.3389/fphar.2022.860209

Cited by 20 publications

(11 citation statements)

References 253 publications

(135 reference statements)

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“…The anti-tumor activity of flavonoids has been extensively described and widely accepted ( Teillet et al, 2008 ). Quercetin, a flavonoid found in abundance in herbal plants and daily consumed foods, can not only restrain the proliferation and induce the apoptosis of various tumor cells via different pathways ( Su et al, 2016 ; Mirazimi et al, 2022 ; Reyes-Avendaño et al, 2022 ), but can also act as a free-radical scavenger to exert antioxidant and anti-inflammatory effects, therefore, inhibiting oncogenesis ( Hsieh et al, 2022 )and inflammatory diseases ( Yang et al, 2022 ). Citrus fruits and extracts of many herbs are also rich in diosmetin ( Roowi and Crozier, 2011 ), another commonly encountered flavone with numerous pharmacological functions, such as anti-inflammation, anti-oxidative stress, and anti-neoplasia ( Roma et al, 2018 ; Chen et al, 2020 ; Ma and Zhang, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

The potential mechanism of Longsheyangquan Decoction on the treatment of bladder cancer: Systemic network pharmacology and molecular docking

Zhang

et al. 2022

Front. Pharmacol.

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Our goal was to explore the bioactive constituents of Longsheyangquan (LSYQ) Decoction and elucidate its mechanisms on the treatment of bladder cancer (BCa). A total of 38 compounds were selected based on their pharmacokinetic properties in three large traditional Chinese medicine (TCM) databases. 654 putative targets of LSYQ Decoction were predicted using a structure-based, reverse-docking algorithm online, of which 343 overlapped with BCa-related protein-coding genes. The protein-protein interaction (PPI) network was constructed to perform module analysis for further Gene Ontology (GO) annotations and Kyoto Encyclopedia Genes and Genomes (KEGG) pathway enrichment analysis, which identified CDK2, EGFR, MMP9 and PTGS2 as hub targets. The TCM-compound-target network and compound-target-pathway network together revealed that quercetin, diosmetin, enhydrin and luteolin were the main components of LSYQ Decoction. Finally, molecular docking showed the affinity between the key compounds and the hub target proteins to verify the accuracy of drug target prediction in the first place. The present study deciphered the core components and targets of LSYQ Decoction on the treatment of BCa in a comprehensive systemic pharmacological manner.

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Section: Discussionmentioning

confidence: 99%

The potential mechanism of Longsheyangquan Decoction on the treatment of bladder cancer: Systemic network pharmacology and molecular docking

Zhang

et al. 2022

Front. Pharmacol.

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“…Quercetin is a type of natural flavonoid isolated from various fruits and vegetables ( Mirazimi et al, 2022 ). Previous studies have shown that quercetin possesses many functions, including anti-cancer, anti-oxidative, and anti-inflammatory properties ( Pinheiro et al, 2021 ; Yin et al, 2021 ; Sun et al, 2022 ).…”

Section: Phytochemicals For the Treatment Of Idd By Targeting Inflamm...mentioning

confidence: 99%

Targeting Oxidative Stress and Inflammation in Intervertebral Disc Degeneration: Therapeutic Perspectives of Phytochemicals

et al. 2022

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Low back pain is a major cause of disability worldwide that declines the quality of life; it poses a substantial economic burden for the patient and society. Intervertebral disc (IVD) degeneration (IDD) is the main cause of low back pain, and it is also the pathological basis of several spinal degenerative diseases, such as intervertebral disc herniation and spinal stenosis. The current clinical drug treatment of IDD focuses on the symptoms and not their pathogenesis, which results in frequent recurrence and gradual aggravation. Moreover, the side effects associated with the long-term use of these drugs further limit their use. The pathological mechanism of IDD is complex, and oxidative stress and inflammation play an important role in promoting IDD. They induce the destruction of the extracellular matrix in IVD and reduce the number of living cells and functional cells, thereby destroying the function of IVD and promoting the occurrence and development of IDD. Phytochemicals from fruits, vegetables, grains, and other herbs play a protective role in the treatment of IDD as they have anti-inflammatory and antioxidant properties. This article reviews the protective effects of phytochemicals on IDD and their regulatory effects on different molecular pathways related to the pathogenesis of IDD. Moreover, the therapeutic limitations and future prospects of IDD treatment have also been reviewed. Phytochemicals are promising candidates for further development and research on IDD treatment.

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“…Many in vitro and in vivo studies have demonstrated the anticancer effects of quercetin against breast, prostate, kidney, colorectal, ovarian, gastric, nasopharyngeal, and pancreatic cancer. The antitumor effects include the inhibition of angiogenesis proliferation, the inhibition of the cell cycle, and tumor metastasis prevention [ 56 ].…”

Section: Nutraceuticalsmentioning

confidence: 99%

The Anticancer Potential of Plant-Derived Nutraceuticals via the Modulation of Gene Expression

Vranceanu

Galimberti

Banc

et al. 2022

Plants

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Current studies show that approximately one-third of all cancer-related deaths are linked to diet and several cancer forms are preventable with balanced nutrition, due to dietary compounds being able to reverse epigenetic abnormalities. An appropriate diet in cancer patients can lead to changes in gene expression and enhance the efficacy of therapy. It has been demonstrated that nutraceuticals can act as powerful antioxidants at the cellular level as well as anticarcinogenic agents. This review is focused on the best studies on worldwide-available plant-derived nutraceuticals: curcumin, resveratrol, sulforaphane, indole-3-carbinol, quercetin, astaxanthin, epigallocatechin-3-gallate, and lycopene. These compounds have an enhanced effect on epigenetic changes such as histone modification via HDAC (histone deacetylase), HAT (histone acetyltransferase) inhibition, DNMT (DNA methyltransferase) inhibition, and non-coding RNA expression. All of these nutraceuticals are reported to positively modulate the epigenome, reducing cancer incidence. Furthermore, the current review addresses the issue of the low bioavailability of nutraceuticals and how to overcome the drawbacks related to their oral administration. Understanding the mechanisms by which nutraceuticals influence gene expression will allow their incorporation into an “epigenetic diet” that could be further capitalized on in the therapy of cancer.

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Application of Quercetin in the Treatment of Gastrointestinal Cancers

Cited by 20 publications

References 253 publications

The potential mechanism of Longsheyangquan Decoction on the treatment of bladder cancer: Systemic network pharmacology and molecular docking

The potential mechanism of Longsheyangquan Decoction on the treatment of bladder cancer: Systemic network pharmacology and molecular docking

Targeting Oxidative Stress and Inflammation in Intervertebral Disc Degeneration: Therapeutic Perspectives of Phytochemicals

The Anticancer Potential of Plant-Derived Nutraceuticals via the Modulation of Gene Expression

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