Quercetin induces protective autophagy and apoptosis through ER stress via the p-STAT3/Bcl-2 axis in ovarian cancer

Liu, Y.; Gong, Wei; Yang, Zongyuan; Xiao, Zhijie; Chen, Gong; Zhang, T. R.; Wu, Xiao; Ma, Ding; Ye, F.; Gao, Qinglei

doi:10.1007/s10495-016-1334-2

Cited by 141 publications

(107 citation statements)

References 36 publications

Supporting

Mentioning

100

Contrasting

Order By: Relevance

“…It is regarded to have protective effect on cardiovascular and respiratory systems. Moreover, it has been shown that quercetin can reduce carcinogens and inhibit the growth of cancer cells (14). It is found that the quercetin flavors extracted from French red wine can effectively inhibit the proliferation of prostate cancer cells and only a small dose is enough, which is equivalent to the amount contained in two cups of red wine every day (15).…”

Section: Introductionmentioning

confidence: 99%

Quercetin prevents alcohol‑induced liver injury through targeting of PI3K/Akt/nuclear factor‑κB and STAT3 signaling pathway

2017

View full text Add to dashboard Cite

Abstract. Quercetin is a type of flavonoid compound, which has potent antioxidant and anti-inflammatory activities, capable of treating a variety of diseases including neurodegenerative diseases, tumors, diabetes and obesity. The present study selected alcohol-induced liver injury model mice and aimed at studying the protective role of quercetin in preventing alcohol-induced liver injury. In alcohol-induced liver injury mice treated with quercetin, it was demonstrated that levels of aspartate transaminase, alanine transaminase, total bilirubin and triglyceride were reduced. In addition to this, the activities of the antioxidant enzymes superoxide dismutase and glutathione peroxidase were increased, malondialdehyde was inhibited, and interleukin (IL)-1β, IL-6, IL-10 and inducible nitric oxide synthase were suppressed. Quercetin additionally suppressed the protein expression levels of B-cell lymphoma (Bcl)-2, Bcl-2 associated X apoptosis regulator, Caspase-3, poly ADP-ribose polymerase, and signal transducer and activator of transcription (STAT) 3 phosphorylation, nuclear factor (NF)-κB and protein kinase B (Akt) phosphorylation levels in alcohol-induced liver injured mice. These results suggested that the protective role of quercetin prevents alcohol-induced liver injury through the phosphoinositide 3-kinase/Akt/NF-κB and STAT3 pathway.

show abstract

Section: Introductionmentioning

confidence: 99%

Quercetin prevents alcohol‑induced liver injury through targeting of PI3K/Akt/nuclear factor‑κB and STAT3 signaling pathway

2017

View full text Add to dashboard Cite

show abstract

“…Also a DPPH free radical scavenging activity (EC50=33.1 ± 0.59 mM) of quercetin was shown [77]. Studies by Liu et al [78] on human ovarian cancer (OC) CAOV3 cells and on primary OC cells provided evidences for a novel role of endoplasmic reticulum (ER-responsible for protein translocation, protein folding, and protein post-translational modifications) stress (perturbations in ER function triggering the unfolded protein response (UPR), a tightly orchestrated collection of intracellular signal transduction reactions designed to restore protein homeostasis; triggering the apoptotic machinery ultimately leading to cell death under severe or chronic stress conditions) as, as authors described, a "double edge sword" participating in quercetin-induced apoptosis [78]. In this study quercetin (40 μM; 80 μM for 48 h) irreversibly evoked ER stress to involve in mitochondria apoptosis pathway via the p-STAT3/ Bcl-2 axis in OC cell lines and in primary OC cells.…”

Section: Chemoprotective Activities In Ovarian Cancer Cells Of Quercementioning

confidence: 88%

“…on suppression of signal transduction activity of several cellular kinases [37,[47][48][49]60,75], induction of apoptosis [52,58], cell cycle arrest [37,55,59]) induction of ER stress activating protective autophagy via the p-STAT3/Bcl-2 axis [78], as well as their strong potential to sensitization of ovarian cancer cells to the presence of several platinum-based cytostatics (cisplatin and oxaliplatin) [75] and others.…”

Section: Discussionmentioning

confidence: 99%

“…For this purpose following in vivo experimental conditions were carried out: 5 days after tumor implantation the mice were treated i.p. with 80 mg/kg of quercetin twice a week; 30 mg/kg 3MA twice a week; a combination of 30 mg/kg 3 MA and 80 mg/kg of quercetin twice a week; or a vehicle control injected with the same volume of saline for 4 weeks [78]. The results of this study are consistent with the trend of predecessor studies [56,60,77] showing that quercetin has the potential to induce protective autophagy in cancer cells through AKT-mTOR and hypoxia-induced factor 1α signaling [79,80] and in this way to induce autophagy in ovarian cancer cells [81].…”

Section: Chemoprotective Activities In Ovarian Cancer Cells Of Quercementioning

confidence: 99%

See 1 more Smart Citation

Basic Studies on Chemopreventive Properties of Quercetin and Curcumin and Other Plant-origin Compounds in Ovarian Cancer Cells – A Mini-review

Kujawski¹,

Baraniak²,

Ożarowski³

et al. 2017

Altern Integr Med

View full text Add to dashboard Cite

Despite the increasing number of studies on the molecular actions of quercetin and curcumin, their anticancer efficacy, safety and molecular aspects of chemopreventive action in the ovarian cancer prophylaxis or treatment and also their potential in the sensitization to cytostatics used in the clinical practice remains still not clearly understood.Based on basic studies we have summarized evidences for inhibitory activities of several often studied plantorigin bio-active compounds (mostly quercetin and curcumin) against ovarian cancer cells proliferation, their mechanisms of action as well as their strong potential to sensitization of ovarian cancer cells to the presence of several platinum-based cytostatics -cisplatin and oxaliplatin. Up to date only several dietary, clinical (cohort and case-control) studies evaluating the association of some flavonoids (mostly nonisoflavones) and its subgroup components consumption and ovarian cancer risk were already performed. According to the researchers, there has been no association between ovarian cancer risk and total nonisoflavone flavonoids intake. There is a still an insufficient amount of data designed to explain the effect of quercetin or curcumin (alone or together) on ovarian cancer development and/or its chemotherapy. Obtained results provide limited support for an association between nonisoflavone flavonoids intake and ovarian cancer risk, therefore there is a need for further and more accurate studies to be confirmed. We are of the opinion that this paper will contribute to a better understanding of the molecular basis for positive interactions between concomitant usage of quercetin or curcumin with above-mentioned cytostatics and other bio-active agents. This work may also contribute to an increase in the number of preclinical studies or other clinical, dietary trials using these or other phenolic / alkaloid, plant-origin constituents in order to investigate efficiency and safety of pharmacotherapy of ovarian cancer patients.

show abstract

“…7,8 Furthermore, autophagy inhibitor 3-methyladenine (3-MA) enhanced quercetin-mediated tumor suppressive effects in mice xenografted with ovarian cancer cells. Quercetin was noted to activate protective autophagy simultaneously by activating the p-STAT3/ Bcl-2 axis.…”

Section: Jak-stat3mentioning

confidence: 99%

Quercetin‐mediated regulation of signal transduction cascades and microRNAs: Natural weapon against cancer

Farooqı

Jabeen

Attar

et al. 2018

J of Cellular Biochemistry

View full text Add to dashboard Cite

Recent technological and analytical breakthroughs in genomics and proteomics have deepened our understanding related to the multifaceted nature of cancer. Because of therapeutically challenging nature of cancer, there has been a renewed interest in phytochemistry, and much attention is currently being given to the identification of signaling pathway inhibitors. Data obtained through high-throughput technologies has provided a broader landscape of wiring maps of complex oncogenic signaling networks, thus revealing novel therapeutic opportunities. Increasingly, it is being realized that although our knowledge related to physiological and pathophysiological roles of signal transduction cascades has evolved rapidly, the clinical development of signaling pathway inhibitors has been challenging. Quercetin has attracted considerable attention because of its amazingly high pharmacological value. Research over decades has sequentially shown that quercetin effectively inhibited cancer development and progression. In this review, we have attempted to set the spotlight on the regulation of different cell signaling pathways by quercetin. We partition this multicomponent review into how quercetin effectively regulates the Wnt/β-catenin pathway, Janus kinase-signal transducer and activator of transcription pathway, and vascular endothelial growth factor/vascular endothelial growth factor receptor signaling cascade in different types of cancers. We also provide an overview of the regulation of NOTCH and SHH pathways by quercetin. MicroRNAs (miRNAs) have also emerged as versatile regulators of cancer, and contemporary studies have shed light on the ability of quercetin to control different miRNAs in various cancers. We have scattered information related to NOTCH and SHH pathways, and future studies must converge on the investigation of these pathways to see how quercetin modulates the signaling machinery of these pathways.

show abstract

Quercetin induces protective autophagy and apoptosis through ER stress via the p-STAT3/Bcl-2 axis in ovarian cancer

Cited by 141 publications

References 36 publications

Quercetin prevents alcohol‑induced liver injury through targeting of PI3K/Akt/nuclear factor‑κB and STAT3 signaling pathway

Quercetin prevents alcohol‑induced liver injury through targeting of PI3K/Akt/nuclear factor‑κB and STAT3 signaling pathway

Basic Studies on Chemopreventive Properties of Quercetin and Curcumin and Other Plant-origin Compounds in Ovarian Cancer Cells – A Mini-review

Quercetin‐mediated regulation of signal transduction cascades and microRNAs: Natural weapon against cancer

Contact Info

Product

Resources

About