Quercetin impregnated chitosan–fibrin composite scaffolds as potential wound dressing materials — Fabrication, characterization and in vivo analysis

Development, Optimization and In Vitro/In Vivo Characterization of Collagen-Dextran Spongious Wound Dressings Loaded with Flufenamic Acid

“…Such NSAIDs-based drug delivery systems (DDS) with non-biodegradable polymers support are to be avoided as they need frequent replacements that affect a patient’s comfort and can cause additional trauma to the new epithelial tissue formed, the risk of secondary infection being very high [ 7 , 9 , 24 , 25 , 26 , 27 ]. Therefore, biodegradable polymers are considered to be ideal vehicles for drugs delivery [ 28 ], collagen being preferred due to its properties such as biodegradability, bioresorbability, biocompatibility, hemostasis ability, well-known structure, and reduced manufacturing cost [ 29 , 30 , 31 , 32 , 33 , 34 , 35 ]. The use of collagen as drug release support is however limited by its mechanical properties and resistance to in vivo enzymatic degradation, but these characteristics could be enhanced by chemical reaction using various crosslinkers such as glutaraldehyde [ 31 , 32 , 36 , 37 ], or by blending with other biopolymers.…”

Surface refined AuQuercetinnanoconjugate stimulates dermal cell migration: possible implication in wound healing

“…The promotive role of quercetin in wound healing scenario is well documented 37 and has been successfully used as a component of scaffolds and hydrogel based wound dressings. 36,38,39 The specic mechanisms by which quercetin NPs enhance healing of wounds is not yet elucidated. It is probable that Au Qur NP functions through inducing collagen synthesis 24 and elongated brilogenesis (Fig.…”

Application of additive manufacturing in customized titanium mandibular implants for patients with oral tumors

“…Current obstacles remain to develop an ideal biocompatible bone repair scaffold that possesses suitable microstructure. Natural biological materials, such as chitosan-fibrin and hydroxyapatite, possess excellent cell adhesion and growth support properties (71,72). However, these polymers lack mechanical strength and physical stability, which limit their application in reconstruction of load-bearing areas of the mandible, and are thus likely to result in the implant failure (70).…”