Surface refined Au<sup>Quercetin</sup>nanoconjugate stimulates dermal cell migration: possible implication in wound healing

Madhyastha, Harishkumar; Halder, Sourav; Intan, N Queen; Madhyastha, Radha; Arumugam, Mohanapriya; Sudhakaran, R.; Sajitha, L S; Banerjee, Kaushita; Bethasiwi, P; Daima, Hemant Kumar; Navya, P. N.; Maruyama, Masugi; Nakajima, Yuichi

doi:10.1039/d0ra06690g

Cited by 22 publications

(7 citation statements)

References 45 publications

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“…The effect of colloidal AuNP coupled with quercetin (Au Qur NPs) on the fibroblast cell migration-assisted wound healing mechanism was depicted by Madhyastha et al Au Qur NPs displayed enhanced cell proliferation and migration of keratinocytes, which was directed through the TGF-β1-dependent SMAD signaling pathway. This initial study on nanoceutical-engineered gold particles brings forth molecular and cellular evidence-based data to elevate the promising healing applications of Au Qur NPs in upcoming nanomedicine for skin etiology [116] (Figure 3).…”

Section: Engineered Metal Composites Implemented For Healingmentioning

confidence: 98%

“…pathway. This initial study on nanoceutical-engineered gold particles brings forth molecular and cellular evidence-based data to elevate the promising healing applications of Au-Qur NPs in upcoming nanomedicine for skin etiology [116] (Figure 3). Zinc-oxide nanoparticles (ZnONPs) exhibit potent antibacterial activity, and combined with hydrogel-based wound dressings [22], can activate keratinocyte migration and improve re-epithelialization [117] (Figure 4).…”

Section: Engineered Metal Composites Implemented For Healingmentioning

confidence: 98%

“…Black, green, and red lines depict the start, end-point of cell migration, and migratory cell edge, respectively (magnification:10X). (reprinted with permission from reference[116]. Reproduced with permission of The Royal Society of Chemistry).…”

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confidence: 99%

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Nanoceutical Adjuvants as Wound Healing Material: Precepts and Prospects

Banerjee

Madhyastha

Nakajima

et al. 2021

IJMS

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Dermal wound healing describes the progressive repair and recalcitrant mechanism of 12 damaged skin, and eventually, reformatting and reshaping the skin. Many probiotics, nutritional supplements, metal nanoparticles, composites, skin constructs, polymers, and so forth have been associated with the improved healing process of wounds. The exact mechanism of material-cellular interaction is a point of immense importance, particularly in pathological conditions such as diabetes. Bioengineered alternative agents will likely continue to dominate the outpatient and perioperative management of chronic, recalcitrant wounds as new products continue to cut costs and improve the wound healing process. This review article provides an update on the various remedies with confirmed wound healing activities of metal-based nanoceutical adjuvanted agents and also other nano-based counterparts from previous experiments conducted by various researchers.

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Section: Engineered Metal Composites Implemented For Healingmentioning

confidence: 98%

Section: Engineered Metal Composites Implemented For Healingmentioning

confidence: 98%

See 1 more Smart Citation

Nanoceutical Adjuvants as Wound Healing Material: Precepts and Prospects

Banerjee

Madhyastha

Nakajima

et al. 2021

IJMS

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“…and their pro-migratory effects were evaluated on fibroblasts and keratinocytes in vitro (141). The rate of cell migration towards the artificially-generated wound edges was reported as the following:…”

Section: Nanoparticlesmentioning

confidence: 99%

Quercetin-loaded Biocomposites for Wound Healing Applications

Nazarnezhad,

Nasiri,

Gorgani

et al. 2024

Preprint

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Skin plays a vital role in protecting the human body from hazardous stimuli such as oxidizing agents and inflammatory triggers. To improve the skin's defense mechanisms against endogenous and exogenous damage, the administration of antioxidants can be a promising strategy. Quercetin (Que) is a well-known flavonoid with prominent antioxidant, anti-inflammatory, anti-aging, and anti-microbial properties, contributing to better wound healing and skin care. However, its poor solubility has limited the penetration capacity into the skin. To overcome this limitation, various formulations and composite strategies have been developed to efficiently increase its cutaneous penetration. Here we have provided an overview of the underlying mechanisms of wound healing with a focus on the therapeutic capability and performance of quercetin in every stage of this process. In the end, a range of drug delivery approaches that promote the transdermal penetration of Que has been discussed.

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“…The FDA has granted Q GRAS (Generally Recognized As Safe) status [ 16 ]. Despite its broad-spectrum effects on the skin, there are several obstacles to Q topical administration, namely its limited aqueous solubility and high lipophilicity, which hinder its skin permeation [ 17 , 18 , 19 ]. Moreover, Q is chemically unstable and very susceptible to oxidation [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Nanostructured Lipid Carriers Enriched Hydrogels for Skin Topical Administration of Quercetin and Omega-3 Fatty Acid

Lúcio,

Giannino,

Barreira

et al. 2023

Pharmaceutics

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Chronic skin exposure to external hostile agents (e.g., UV radiation, microorganisms, and oxidizing chemicals) may increase oxidative stress, causing skin damage and aging. Because of their well-known skincare and protective benefits, quercetin (Q) and omega-3 fatty acids (ω3) have attracted the attention of the dermocosmetic and pharmaceutical sectors. However, both bioactives have inherent properties that limit their efficient skin delivery. Therefore, nanostructured lipid carriers (NLCs) and enriched PFC® hydrogels (HGs) have been developed as a dual-approach vehicle for Q and/or ω3 skin topical administration to improve bioactives’ stability and skin permeation. Two NLC formulations were prepared with the same lipid composition but differing in surfactant composition (NLC1—soy lecithin and poloxamer 407; NLC2—Tween® 80 and dioctyl sodium sulfosuccinate (DOSS)), which have an impact on physicochemical properties and pharmaceutical and therapeutic performance. Despite both NLCs presenting high Q loading capacity, NLC2′s physicochemical properties make them more suitable for topical skin administration and ensure longer colloidal stability. Additionally, NLC2 demonstrated a more sustained Q release, indicating higher bioactive storage while improving permeability. The occlusive effect of NLCs-enriched HGs also has a positive impact on skin permeability. Q-loaded NLC2, with or without ω3, -enriched HGs demonstrated efficacy as antioxidant and photoprotective formulations as well as effective reduction in S. aureus growth, indicating that they constitute a promising approach for topical skin administration to prevent skin aging and other damaging cutaneous processes.

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Surface refined Au^Quercetinnanoconjugate stimulates dermal cell migration: possible implication in wound healing

Abstract: AuQuercetin nano conjugates enhances cell migration via TGFβ1.

Cited by 22 publications

References 45 publications

Nanoceutical Adjuvants as Wound Healing Material: Precepts and Prospects

Nanoceutical Adjuvants as Wound Healing Material: Precepts and Prospects

Quercetin-loaded Biocomposites for Wound Healing Applications

Nanostructured Lipid Carriers Enriched Hydrogels for Skin Topical Administration of Quercetin and Omega-3 Fatty Acid

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Surface refined AuQuercetinnanoconjugate stimulates dermal cell migration: possible implication in wound healing

Abstract: AuQuercetin nano conjugates enhances cell migration via TGFβ1.

Cited by 22 publications

References 45 publications

Nanoceutical Adjuvants as Wound Healing Material: Precepts and Prospects

Nanoceutical Adjuvants as Wound Healing Material: Precepts and Prospects

Quercetin-loaded Biocomposites for Wound Healing Applications

Nanostructured Lipid Carriers Enriched Hydrogels for Skin Topical Administration of Quercetin and Omega-3 Fatty Acid

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Product

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Surface refined Au^Quercetinnanoconjugate stimulates dermal cell migration: possible implication in wound healing