Quercetin Dampens Postprandial Hyperglycemia in Type 2 Diabetic Patients Challenged with Carbohydrates Load

Abstract

Postprandial hyperglycemia is a major risk factor for diabetic co mp licat ions leading to disabilities and mortality in diabetics. Quercetin, a flavonoid, has been tried in trad itional med icine for treat ing many disorders including diabetes. The present study was designed to evaluate the potential of quercetin to damp postprandial blood glucose level after maltose and glucose loading in patients with type 2 diabetes mellitus (DM). In a rando mized, b linded crossover study, single oral dose (400mg) of quercetin or placebo formula was ad min istered to the patients 30 min before loading with either maltose (2g/kg) or g lucose (100g), blood samp les are taken at different intervals for measurement of plas ma g lucose. The results clearly showed amelio rated postprandial hyperglycemia due to the use of quercetin, it significantly dampened the postprandial hyperglycemia only after maltose loading compared to placebo; no effect reported for quercetin after glucose loading. In conclusion, quercetin effectively suppresses postprandial hyperglycemia in patients with type 2 DM loaded with maltose, which may be attributed to α-glucosidase inhibition.

Quercetin and metabolic syndrome: A review

“…Quercetin reduced maltose-induced postprandial hyperglycemia while did not affect hyperglycemia-induced glucose. The hypoglycemic effect of quercetin is linked to the prevention of α-glucosidase (Hussain et al, 2012). In a randomized study, the type 2 diabetic patients received quercetin at a dose of 250 mg/day for 8 weeks.…”

Therapeutic Properties of Stingless Bee Honey in Comparison with European Bee Honey

“…The potential role of honey polyphenols in inhibiting α -amylase and α -glucosidase enzymes that facilitate carbohydrate breakdown has been confirmed. Quercetin successfully inhibits the α -glucosidase enzymes and reduces maltose-induced postprandial hyperglycemia in patients diagnosed with type 2 diabetes mellitus (T2DM) [96]. Meanwhile, another study proved the inhibition of α -amylase and α -glucosidase by luteolin and luteolin-7-0-glycoside [97].…”

Pancreatic regenerative potential of manuka honey evidenced through pancreatic histology and levels of transcription factors in diabetic rat model

“…Besides, polyphenols present in manuka have been known to play role in controlling hyperglycemia via inhibition of α -amylase and α -glucosidase which are involved in carbohydrate breakdown. Quercetin efficiently hinders α -glucosidase enzymes and decreases maltose-induced postprandial hyperglycemia in diabetic individuals [ 46 ]. Another polyphenol luteolin is also shown to supress the activity of α -amylase and α -glucosidase thus ameliorating hyperglycemia [ 47 ].…”