Quercetin and metabolic syndrome: A review

Abstract

Metabolic syndrome (MetS) is a complex of diseases that lead to mortality due to the development of cardiovascular problems. Quercetin, as an important flavonoid, has various properties such as decreasing blood pressure, anti-hyperlipidemia, anti-hyperglycemia, anti-oxidant, antiviral, anticancer, anti-inflammatory, anti-microbial, neuroprotective, and cardio-protective effects. In this review article, we collected original articles from different sources such as Google Scholar, Medline, Scopus, and Pubmed, which is related to the effect of quercetin on the improvement of the signs of MetS, including elevated glucose level, hyperlipidemia, obesity, and blood pressure.According to these data, quercetin may also have a role in the management of metabolic disorders via different mechanisms such as increasing adiponectin, decreasing leptin, anti-oxidant activity, reduction of insulin resistance, the elevation of insulin level, and blocking of calcium channel. We have attempted to make some recommendations on the quercetin application in patients. However, it needs to do further clinical trials and more investigations to show the real clinical value of quercetin on metabolic syndrome.

Quercetin Attenuates Cardiac Hypertrophy by Inhibiting Mitochondrial Dysfunction Through SIRT3/PARP-1 Pathway

“…Quercetin, one of the most distributed bioflavonoids, is widely present in a variety of vegetables and fruits. A growing number of studies have reported beneficial effects for quercetin in cardiovascular disease, cancer, metabolic syndrome, Alzheimer's disease, and nervous system disorders (Ebrahimpour et al, 2020;Hosseini et al, 2021). In the present study, quercetin decreased blood pressure and cardiac hypertrophy, including cardiomyocyte hypertrophy and cardiac fibrosis as revealed by changed left ventricular structure and enhanced collagen I and α-SMA, in vivo.…”

Changes in the Polyphenolic Profile and Antioxidant Activity of Wheat Bread after Incorporating Quinoa Flour

“…The more abundant compounds in QB, namely p -hydroxybenzoic acid, quercetin, and rutin (in the EPF) and acids ferulic and sinapic (in the HPF), are dietary polyphenols with potential biological activities. Several appreciable therapeutic roles have been attributed to them for their antioxidant capacity, and they could, hence, confer bread interesting functional properties [ 39 , 40 , 41 , 42 , 43 , 44 ]. Some in vivo studies have examined their potential biological effects.…”

“…No studies addressing the effect of this compound on animal or preclinical disease models have been found in literature searches. Many studies in animals and humans that refer to quercetin and rutin show their anticancer, anti-inflammatory, antidiabetic, and anti-degenerative activities, among others (see the reviews on the subject and references therein: [ 39 , 43 , 46 , 47 , 48 , 49 ]). Recently, Lai and Wong [ 50 ] reviewed the interest in the optimization of quercetin-based functional foods and referred to clinical studies that support the health benefits of the oral intake of this flavonoid.…”

Flavonoids Seen through the Energy Perspective

“…A higher intake of these compounds has been associated with a reduced incidence of oxidative stress-related diseases, such as cardiovascular diseases and cancer [ 13 , 14 , 15 ]. This group comprises over 5000 different compounds [ 16 ]. Despite extensive ongoing research on flavonoids for several decades, much about the mode of action of flavonoids is still unknown.…”