Quercetin-Based Nanocomposites as a Tool to Improve Dental Disease Management

Abstract

The restoration and prosthetic rehabilitation of missing teeth are commonly performed using dental implants, which are extremely effective and long-lasting techniques due to their osteointegration ability with the preimplant tissues. Quercetin is a phytoestrogen-like flavonoid well known for its several positive effects on human health, mostly linked to the anti-inflammatory, antioxidant, and antibacterial activities against both Gram-positive and Gram-negative bacteria. Moreover, many studies in dentistry and the maxillofacial fields have highlighted the positive effects of quercetin on osteogenesis, acting on osteoblast activity and angiogenetic process, and promoting soft and hard tissue regeneration. This review focuses on the role of quercetin on the healing and restoration of bony defects, considering the experimental findings of its application both in vitro and in vivo as a mere compound or in association with scaffolds and dental implants having functionalized surfaces.

Quercetin-Coating Promotes Osteogenic Differentiation, Osseointegration and Anti-Inflammatory Properties of Nano-Topographic Modificated 3D-Printed Ti6Al4V Implant

“…Taking the in vitro and in vivo observations into account, the quercetin-coated nano-topographic modificated 3D-printed Ti6Al4V manifested superiority compared to the control group, which may owe to the capabilities of stimulating osteogenic differentiation and anti-inflammation of quercetin( Angellotti et al, 2020 ).…”

Green Extraction of Polyphenols from Waste Bentonite to Produce Functional Antioxidant Excipients for Cosmetic and Pharmaceutical Purposes: A Waste-to-Market Approach

“…Similarly, when properly used, polyphenols may exert beneficial and protective activities on human health due to their wide range of therapeutic properties such as antioxidant, antiaging, anti-hyperpigmentation, photoprotective, anticancer and immunomodulatory effects. These lead us to consider them precious active ingredients in pharmaceutical, food and cosmetic products [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. Polyphenols are generally characterized by at least one benzene ring with one or more hydroxyl substituents [ 23 ].…”

Metronidazole- and Amoxicillin-Loaded PLGA and PCL Nanofibers as Potential Drug Delivery Systems for the Treatment of Periodontitis: In Vitro and In Vivo Evaluations

“…Polymers used in the manufacturing of intrapocket drug delivery systems are either of natural origin, such as chitosan, cellulose, and alginate, or they are synthetic, such as poly(ε-caprolactone) (PCL), poly(D, L-lactide) (PLA), poly-(D,L-lactide-co-glycolide) (PLGA), poly-(vinylpyrrolidone) (PVP), and poly(vinyl alcohol) (PVA) [17][18][19]. Polymeric sustained-release drug delivery systems are designed and used for various aims, such as ocular [20] and periodontal [21] delivery.…”