Quercetin Attenuates Oxidative Stress, Inflammation and Cardiac Dysfunction in Acrylamide- Induced Cardiotoxicity

Kushwah, Ajay Singh; Kalia, Taranbir S.

doi:10.32383/appdr/110094

Cited by 2 publications

(4 citation statements)

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“…Histopathological Findings ACR: Acrylamide, SEL: Selenium. were found with our study and that ACR increased the levels of cardiac damage markers by causing damage to the heart tissue (39). As a result of these studies, the existence of cardiotoxic effects of ACR on heart tissue can be considered, and our study may be a guide to investigate the cardiotoxic effect of ACR on other living things, especially humans.…”

Section: Discussionsupporting

confidence: 74%

“…In this study, ACR not only led to an increase in biochemical marker levels, but also histopathological, it caused some changes such as disorganization in cardiac muscle fibers, increased connective tissue between muscle fibers and irregular eosinophilia in muscle fibers. Again, in the study of Kushwah et al, increased inflammatory cell infiltration, loss of myocardial tissue and interstitial spaces trying to fill its place, nuclear loss and vacuolization in the heart tissues of rats in the ACR group were shown (39).…”

Section: Parameters / Groupmentioning

confidence: 93%

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Akri̇lami̇de Maruz Kalan Siçanlarin Kalp Dokusu Üzeri̇nde Selenyumun Koruyucu Rolü

KARAKUYU

Aşçı

Savran

et al. 2023

SDÜ Tıp Fakültesi Dergisi

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Objective: Acrylamide (ACR) is a harmful organic reactive compound widely used in different industrial fields. Selenium (SEL) is a trace element that takes part in some chemical and enzymatic reactions in both animals and human organisms and can cause some disorders in many systems such as the cardiovascular system in case of deficiency. The aim of this study is to investigate whether SEL has a protective effect on cardiac tissue in experimentally induced ACR toxicity in rats. Material and Methods: A total of 28 rats were randomly and equally divided into four groups: Control, SEL, ACR, SEL + ACR. At the end of the study, cardiac markers such as creatine kinase MB (CKMB), lactate dehydrogenase (LDH) and ischemia-modified albumin (IMA) from blood samples were measured. Oxidative stress markers such as total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) in heart tissue were analyzed. In addition, inducible nitric oxide synthase iNOS activities were determined in heart sections using immunohistochemical methods. Results: The ACR + SEL group showed a significant decrease in TOS, OSI, CKMB, LDH, IMA levels and significant increase in TAS level compared to the ACR group. In histopathological and immunohistochemical evaluation of the heart sections; Disorganization in cardiac muscle fibers, increased connective tissue between muscle fibers and irregular eosinophilia in muscle fibers were detected in ACR group. A decrease in histopathological findings was observed in the SEL treated group compared to the ACR group. iNOS immunoreactivities; Moderate marking was observed in the ACR group sections, while poor marking was observed in the treatment group. Conclusion: We determined that ACR caused damage to the heart tissue of rats through various metabolic pathways and that these damages were reversed in the groups given the SEL.

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Section: Discussionsupporting

confidence: 74%

Section: Parameters / Groupmentioning

confidence: 93%

Akri̇lami̇de Maruz Kalan Siçanlarin Kalp Dokusu Üzeri̇nde Selenyumun Koruyucu Rolü

KARAKUYU

Aşçı

Savran

et al. 2023

SDÜ Tıp Fakültesi Dergisi

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“…Taxifolin treatment steadily increased all three parameters by the end of the first and second months. Acrylamide-related body weight loss and decrease in water and food intake may be associated with alterations in thirst and hunger regulation centers in the hypothalamus and may also be related to the significant gut oxidative stress due to a decrease of antioxidant levels [25,26]. Previous studies have shown that acrylamide-induced cytotoxicity is mediated through mitochondrial dysfunction and oxidative stress [27].…”

Section: Discussionmentioning

confidence: 99%

“…However, the TOS and TAS levels of the TACL group were found to be close to the HG, suggesting the inhibitory effect of taxifolin on oxidative damage. Recently Kushwah et al demonstrated that the protective effect of flavonoids is more beneficial with high-dose treatment compared to the low-dose [26]. In this term, to avoid inappropriate cooking techniques, increasing the intake of dietary antioxidants can reduce the harmful effects of acrylamide.…”

Section: Discussionmentioning

confidence: 99%

The preventive effect of taxifolin on acrylamide-induced heart damage in rats

Coşgun

Coskun

Çelik³

2022

Rev. Nutr.

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Objective Acrylamide is a toxic compound widely used in industrial sectors. Acrylamide causes reactive oxygen species formation and the subsequent lipid peroxidation reaction, which plays an important role in the pathogenesis of oxidative damage. Taxifolin is a flavonoid with antioxidant properties that inhibit reactive oxygen species formation. In this study, we aimed to investigate the preventive effect of taxifolin on acrylamide-induced oxidative heart damage. Methods The rats were divided into three groups: Acrylamide, Acrylamide+Taxifolin , and Healthy group. Water and food intake and body weight alterations were recorded daily. Malondialdehyde, total glutathione, nuclear factor kappa-B, total oxidant status, and total antioxidant status levels were analyzed from the heart tissue. Troponin-I levels, the parameter known as a cardiac biomarker, were analyzed from the blood sample. The cardiac histopathologic examination was also performed. Results In the Acrylamide group animals, the malondialdehyde, nuclear factor kappa-B, total oxidant status, and troponin-I levels were significantly higher compared to the ones of Acrylamide+Taxifolin and Healthy groups. The levels of total glutathione and total antioxidant status were significantly lower compared to Acrylamide+Taxifolin and Healthy groups’. Additionally, in the Acrylamide group, body weight gain, food and water intake, significantly declined compared to the Acrylamide+Taxifolin and Healthy groups. However, in the Acrylamide+Taxifolin group, taxifolin supplementation brought these values close to Healthy group ones. Furthermore, taxifolin treatment ameliorated structural myocardial damage signs induced by acrylamide. Conclusion Acrylamide exposure significantly induced oxidative damage to rat heart tissue. Taxifolin was able to improve the toxic consequences of acrylamide biochemically and histopathologically, possibly due to its antioxidant properties.

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Quercetin Attenuates Oxidative Stress, Inflammation and Cardiac Dysfunction in Acrylamide- Induced Cardiotoxicity

Cited by 2 publications

References 0 publications

Akri̇lami̇de Maruz Kalan Siçanlarin Kalp Dokusu Üzeri̇nde Selenyumun Koruyucu Rolü

Akri̇lami̇de Maruz Kalan Siçanlarin Kalp Dokusu Üzeri̇nde Selenyumun Koruyucu Rolü

The preventive effect of taxifolin on acrylamide-induced heart damage in rats

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