Quercetin and MicroRNA Interplay in Apoptosis Regulation in Ovarian Cancer

Abstract

: The multifaceted nature of ovarian cancer has severely hampered the development of effective therapeutics over the years. The composite nature of ovarian cancer makes it therapeutically challenging, therefore, there has been a renewed interest in phytochemistry. Phytochemicals have emerged as a potential therapeutic option due to their limited cytotoxicity and high specificity. Moreover, their signaling inhibition properties have also been studied extensively in recent times. A growing number of data obtained through high-throughput technologies has started to delineate the complex oncogenic signaling networks, thus broadening the therapeutic opportunities. Within such network, microRNAs (miRNAs) have been shown to play a versatile role in the regulation of cancer. Quercetin has been in the spotlight over the years because of its high pharmacological values and substantial evidence has demonstrated its anti-proliferative efficacy against various types of cancers. Despite the versatility of quercetin, little is known about its anti-proliferative potential towards ovarian cancer. This review sheds some light on the importance of quercetin as an alternative therapeutic approach to this tumor, furthermore addressing the interplay between miRNAs and quercetin in the regulation of apoptosis in ovarian cancer.

Gou Qi Zi inhibits proliferation and induces apoptosis through the PI3K/AKT1 signaling pathway in non-small cell lung cancer

“…These results are consistent with a previous study showing that quercetin, a flavonoid extracted from GQZ, inhibited the growth of lung tumors and induced apoptosis by upregulating pro-apoptosis and downregulating anti-apoptosis genes (43). Quercetin has been shown to have anticancer activity, inhibiting cell proliferation and metastasis and inducing apoptosis and autophagy (44)(45)(46)(47). Quercetin was found to inhibit resistance to docetaxel in prostate cancer through the PI3K/AKT signaling pathway (48), to inhibit the AKT/CSN6/C-MYC signaling pathway and induce apoptosis of HT-29 colon cancer cells (49), and to increase the sensitivity of ovarian cancer cells to chemotherapy (50).…”

Quercetin Induces Cell Cycle Arrest and Apoptosis in YD10B and YD38 Oral Squamous Cell Carcinoma Cells

“…Numerous studies have reported that quercetin played an important role in preventing the progression of various cancers (Ozsoy et al, 2020;Khan et al, 2021). In oral cancer, quercetin suppressed cell proliferation, migration, and invasion by inducing cell cycle arrest and apoptosis (Ma et al, 2018;Li et al, 2019a;Zhao et al, 2019).…”

Identification of the hub genes and transcription factor‑miRNA axes involved in Helicobacter pylori‑associated gastric cancer

“…Therefore, identification of the mechanisms of HP-associated gastric cancer is required to prevent progression and improve survival times. In recent years, high-throughput technology has been widely utilized to investigate gene expression levels in various types of tumor, such as colorectal ( 32 ) and ovarian cancer ( 33 ), providing a novel method to identify significant genes and determine their effects on tumor progression and initiation ( 34 , 35 ).…”