Quercetin Induces Cell Cycle Arrest and Apoptosis in YD10B and YD38 Oral Squamous Cell Carcinoma Cells

Abstract

Asian Pac J Cancer Prev, 24 (1), 283-289 (>40%) among the patients with head and neck cancers, predominantly occurring in the oral cavity and lips (Markopoulos, 2012;Liu et al., 2019) Treatment for OSCC involves surgery, or a combination of surgery, radiation and chemotherapy. However, these therapies can cause a variety of side effects such as facial defects, malformation, dysfunction, drug resistance, and toxicity which lead to poor quality of life (Blatt et al., 2017;Liu et al., 2019). Thus, many studies have shifted their attention to natural compounds, which have little toxicity as new therapeutic agents for treating cancers (Demain and Vaishnav, 2011;Khalifa et al., 2019) Natural products have been used as one of therapeutic

Jiawei Danxuan Koukang Alleviates Arecoline Induced Oral Mucosal Lesions: Network Pharmacology and the Combined Ultra-High Performance Liquid Chromatography (UPLC) and Mass Spectrometry (MS)

“… 32 Quercetin inhibited cell proliferation, G1 cycle arrest, and apoptosis by activating the p38 signaling pathway in OSCC cells with different p53 states. 58 Network pharmacological analysis showed that quercetin and AR were the active ingredients and key targets of JDK, metabolites and oral mucosal fibrosis interaction, and there was interaction between them. Arecoline promoted the expression of AR protein and the proliferation in oral fibroblasts, reflecting the malignant characteristics of OSF histopathology.…”

Study on the mechanism of quercetin in Sini Decoction Plus Ginseng Soup to inhibit liver cancer and HBV virus replication through CDK1

“…There is increasing evidence that quercetin exhibits anti‐tumor activity through a variety of pathways in liver cancer, such as through the JAK2/STAT3 signaling pathway (Wu et al., 2019), MEK1/ERK1/2 signaling pathway (Fernández‐Palanca et al., 2019), Wnt/β‐catenin signaling pathway (Zhao et al., 2021). Moreover, previous experiments have shown that quercetin prevents the growth of a variety of tumors by inhibiting the cell cycle and inducing apoptosis, including liver cancer, breast cancer, oral squamous cell carcinoma cells (Azizi et al., 2022; Hisaka et al., 2020; Son & Kim, 2023). In this study, we found that quercetin targeted HBV‐related HCC through multiple targets and multiple pathways, among which the most obvious targets were CDK1 and CCNB1.…”

Comparative Study of Biochemical Compounds and Its Related Therapeutic Efficacy of Iphiona Mucronata and Conyza Dioscorides

“…The inhibition of cancer cell growth against tested cancer cells of I. mucronata EtOAc extract may be due to different mechanism pathways of the chemical components where, presence of quercetin, kaempferol, apigenin and luteolin flavonoids can inhibit enzymes involved in cell growth and proliferation, such as kinases and cyclin-dependent kinases (CDKs), which bind to and activate tumor suppressor proteins. Also, modulating signaling pathways: where flavonoids can interfere with pathways like PI3K/Akt and MAPK, which are crucial for cancer cell survival and migration (Son and Kim, 2023) and scavenge free radicals and reactive oxygen species (ROS) that can damage DNA and promote cancer cell growth, prevent the formation of new blood vessels, which are essential for tumor growth and metastasis (inhibition of angiogenesis) (Luna et al, 2023). Also can trigger programmed cell death in cancer cells to induce apoptosis and modulation of signaling pathways by interfering with signaling pathways that promote cancer cell proliferation and survival (Yan et al, 2017).…”