Quercetin ameliorates kidney injury and fibrosis by modulating M1/M2 macrophage polarization

Lu, Hong; Wu, Lianfeng; Liu, Leping; Ruan, Qingqing; Zhang, Xing; Hong, Weilong; Wu, Shijia; Jin, Guihua; Bai, Yongheng

doi:10.1016/j.bcp.2018.05.007

Cited by 167 publications

(106 citation statements)

References 40 publications

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“…A very recent study reported that CXCL14 analogs including CXCL14-C17-a2 and CXCL14-C17-a3 effectively inhibited the production of TNF-α and IL-6 from LPS-stimulated RAW264.7 cells [26]. In addition, it has been widely accepted that macrophage is one of the major sources of inflammatory cytokine production during sepsis [27], and sepsis-associated AKI is related to the polarization of proinflammatory M1 or antiinflammatory M2 [28]. M1 macrophage contributes to the excessive production of proinflammatory cytokines and AKI, but M2 macrophage accelerates tissue repair and inhibits proinflammatory cytokine production [29].…”

Section: Discussionmentioning

confidence: 99%

CXCL14 Overexpression Attenuates Sepsis-Associated Acute Kidney Injury by Inhibiting Proinflammatory Cytokine Production

Gan

et al. 2020

Mediators of Inflammation

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CXCL14 is a relatively novel chemokine with a wide spectrum of biological activities. The present study was designed to investigate whether CXCL14 overexpression attenuates sepsis-associated acute kidney injury (AKI) in mice. Sepsis model has been established by cecal ligation and puncture (CLP). CLP induced AKI in mice as assessed by increased renal neutrophil gelatinase-associated lipocalin (NGAL) expression and serum creatinine levels. We found that renal CXCL14 expression in the kidney was significantly decreased at 12 hours after CLP. Correlation analysis demonstrated a negative association between renal CXCL14 expression and AKI markers including serum creatinine and renal NGAL. Moreover, CXCL14 overexpression reduced cytokine (TNF-α, IL-6, and IL-1β) production and NGAL expression in the kidney and decreased serum creatinine levels. In vivo and in vitro experiments found that CXCL14 overexpression inhibited M1 macrophage polarization but increased M2 polarization. Together, these results suggest that CXCL14 overexpression attenuates sepsis-associated AKI probably through the downregulation of macrophages-derived cytokine production. However, further studies are required to elucidate the underlying mechanism.

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Section: Discussionmentioning

confidence: 99%

CXCL14 Overexpression Attenuates Sepsis-Associated Acute Kidney Injury by Inhibiting Proinflammatory Cytokine Production

Gan

et al. 2020

Mediators of Inflammation

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“…Another novel finding of this study was a new classification of restorative macrophage with Ly6c expression that was recruited by M1 and M φ , which is responsible for anti-fibrosis and hepatocyte proliferation improvement effects [33]. It has been reported that polarized macrophages also play important roles in fibrosis of different organs including kidney and cardiovascular systems, suggesting the importance of maintaining the balance of M1/M2 polarization to avoid the occurrence of pro-fibrotic events [63,64,65]. The circumstance suggested promoting neither M1 nor M2 macrophage polarization in disease amelioration was in development of glutathione S-transferase-placenta form-positive (preneoplasetic) lesions in a TAA-induced liver cirrhosis rat model.…”

Section: Role Of Macrophages In Liver Protectionmentioning

confidence: 99%

Chemopreventive Effects of Phytochemicals and Medicines on M1/M2 Polarized Macrophage Role in Inflammation-Related Diseases

Koh

Yang

Lai

et al. 2018

IJMS

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Macrophages can polarize into two different states (M1 and M2), which play contrasting roles during pathogenesis or tissue damage. M1 polarized macrophages produce pro-inflammatory cytokines and mediators resulting in inflammation, while M2 macrophages have an anti-inflammatory effect. Secretion of appropriate cytokines and chemokines from macrophages can lead to the modification of the microenvironment for bridging innate and adaptive immune responses. Increasing evidence suggests that polarized macrophages are pivotal for disease progression, and the regulation of macrophage polarization may provide a new approach in therapeutic treatment of inflammation-related diseases, including cancer, obesity and metabolic diseases, fibrosis in organs, brain damage and neuron injuries, and colorectal disease. Polarized macrophages affect the microenvironment by secreting cytokines and chemokines while cytokines or mediators that are produced by resident cells or tissues may also influence macrophages behavior. The interplay of macrophages and other cells can affect disease progression, and therefore, understanding the activation of macrophages and the interaction between polarized macrophages and disease progression is imperative prior to taking therapeutic or preventive actions. Manipulation of macrophages can be an entry point for disease improvement, but the mechanism and potential must be understood. In this review, some advanced studies regarding the role of macrophages in different diseases, potential mechanisms involved, and intervention of drugs or phytochemicals, which are effective on macrophage polarization, will be discussed.

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“…The results of this study indicated that C-QA decreased LPS-induced kidney damage by suppressing oxidative stress, inflammation, apoptosis and autophagy, enhancing kidney regeneration (111). M2/M1 macrophage polarization modulation (112) increased the ability of quercetin to reduce kidney damage and fibrosis, and treatment with quercetin improved kidney function, reduced oxidation stress factors, serum fibroblast growth factor 23 (FGF23) levels, and renal inflammation in a rat model of adenine-induced chronic kidney disease (113). Quercetin also reduced kidney damage from doxorubicin (114).…”

Section: Polyphenols Microbiota and Ckdmentioning

confidence: 66%

The Regulation of Host Intestinal Microbiota by Polyphenols in the Development and Prevention of Chronic Kidney Disease

2020

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Quercetin ameliorates kidney injury and fibrosis by modulating M1/M2 macrophage polarization

Cited by 167 publications

References 40 publications

CXCL14 Overexpression Attenuates Sepsis-Associated Acute Kidney Injury by Inhibiting Proinflammatory Cytokine Production

CXCL14 Overexpression Attenuates Sepsis-Associated Acute Kidney Injury by Inhibiting Proinflammatory Cytokine Production

Chemopreventive Effects of Phytochemicals and Medicines on M1/M2 Polarized Macrophage Role in Inflammation-Related Diseases

The Regulation of Host Intestinal Microbiota by Polyphenols in the Development and Prevention of Chronic Kidney Disease

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