Quercetagetin loaded in soy protein isolate–κ-carrageenan complex: Fabrication mechanism and protective effect

Wang, Weiyou; Liu, Fuguo; Gao, Yanxiang

doi:10.1016/j.foodres.2016.02.012

Cited by 61 publications

(28 citation statements)

References 53 publications

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“…In this paper, multi-speckle diffusing wave spectroscopy (MS-DWS) analysis was carried out in association with rheology studies to evaluate the possible changes in rheological features and in gelling temperature of different Poloxamer 407 hydrogels when colloidal carriers were embedded. MS-DWS data, elasticity index and solid-liquid balance determination were investigated using the Rheolaser Master™, which allows no manipulation and no mechanical stress to be applied to the sample [16]; in fact, the Rheolaser Master™ is based on a passive microrheology analysis and the sample can be recovered. This technique allows the monitoring of sample evolution like gelation, rheology ageing and stability.…”

Section: Introductionmentioning

confidence: 99%

The Rheolaser Master™ and Kinexus Rotational Rheometer® to Evaluate the Influence of Topical Drug Delivery Systems on Rheological Features of Topical Poloxamer Gel

et al. 2020

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Poloxamer 407 copolymer is a versatile and widely used thermo-reversible material. Its use has many advantages, such as bio-adhesion, enhanced solubilization of poorly water-soluble drugs and many applications fields like oral, rectal, topical, nasal drug administration. Hydrogels made up of Poloxamer 407 are characterized by specific rheological features, which are affected by temperature, concentration and presence of other compounds. A strategic approach in topical therapeutic treatments may be the inclusion of drug delivery systems, such as ethosomes, transfersomes and niosomes, into hydrogel poloxamer formulation. The evaluation of the interaction between colloidal carriers and the Poloxamer 407 hydrogel network is essential for a suitable design of an innovative topical dosage form. For this reason, the Rheolaser Master™, based on diffusing wave spectroscopy, and a Kinexus Rotational Rheometer were used to evaluate the influence of nanocarriers on the microrheological features of hydrogels. The advantages of the Rheolaser Master™ analyzer are: (i) its ability to determine viscoelastic parameter, without altering or destroying the sample and at rest (zero shear); (ii) possibility of aging analysis on the same sample. This study provide evidence that vesicular systems do not influence the rheological features of the gel, supporting the possibility to encapsulate an innovative system into a three-dimensional network.

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Section: Introductionmentioning

confidence: 99%

The Rheolaser Master™ and Kinexus Rotational Rheometer® to Evaluate the Influence of Topical Drug Delivery Systems on Rheological Features of Topical Poloxamer Gel

et al. 2020

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“…As seen from Figure 9B , at 50°C under dark circumstances, a similar effect was observed. The active groups of 7,8-DHF were possibly protected within the hydrophobic lumen of zein/glycosylated LF nanoparticles as a mechanism ( 50 ), especially DHF-zein/LF 70K (46.33%). The above results were in conformance to preceding studies that introduced curcumin being embedded in zein and quaternized chitosan complexes, along with work showing that quercetagetin was loaded within the zein-hyaluronic acid binary complex.…”

Section: Resultsmentioning

confidence: 99%

Establishment and Characterization of Stable Zein/Glycosylated Lactoferrin Nanoparticles to Enhance the Storage Stability and in vitro Bioaccessibility of 7,8-Dihydroxyflavone

et al. 2022

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In this work, the lactoferrin (LF) was glycosylated by dextran (molecular weight 10, 40, and 70 kDa, LF 10K, LF 40K, and LF 70K) via Maillard reaction as a stabilizer to establish zein/glycosylated LF nanoparticles and encapsulate 7,8-dihydroxyflavone (7,8-DHF). Three zein/glycosylated LF nanoparticles (79.27–87.24 nm) with low turbidity (<0.220) and polydispersity index (PDI) (<0.230) were successfully established by hydrophobic interactions and hydrogen bonding. Compared with zein/LF nanoparticles, zein/glycosylated LF nanoparticles further increased stability to ionic strength (0–500 mM NaCl) at low pH conditions. Zein/glycosylated LF nanoparticles had nanoscale spherical shape and glycosylated LF changed surface morphology of zein nanoparticles. Besides, encapsulated 7,8-DHF exhibited an amorphous state inside zein/glycosylated LF nanoparticles. Most importantly, zein/glycosylated LF nanoparticles had good water redispersibility, high encapsulation efficiency (above 98.50%), favorable storage stability, and bioaccessibility for 7,8-DHF, particularly LF 40K. Collectively, the above research provides a theoretical reference for the application of zein-based delivery systems.

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“…At 50 °C under dark conditions (Figure 8B), a sim fect was observed. The active groups of 7,8-DHF were possibly protected within drophobic lumen of DHF-S/Z, DHF-CMC/S/Z, and DHF-ALG/S/Z nanoparticle mechanism [50], besides, due to the different chemical structures of CMC and ALG CMC/S/Z have higher EE, which caused more 7,8-DHF to be protected in the hydro part. These results are in agreement with previous studies that introduced curcumin embedded in zein and quaternized chitosan complexes [51], along with work showi quercetagetin was loaded using the zein-hyaluronic acid binary complexes [52].…”

Section: Storage Stability Of 78-dhfmentioning

confidence: 99%

“…ods 2021, 10, x. https://doi.org/10.3390/xxxxx www.mdpi.com/journal mechanism [50], besides, due to the different chemical structures of CMC and ALG, D CMC/S/Z have higher EE, which caused more 7,8-DHF to be protected in the hydroph part. These results are in agreement with previous studies that introduced curcumin b embedded in zein and quaternized chitosan complexes [51], along with work showing quercetagetin was loaded using the zein-hyaluronic acid binary complexes [52].…”

Section: Storage Stability Of 78-dhfmentioning

confidence: 99%

Development, Characterization, Stability and Bioaccessibility Improvement of 7,8-Dihydroxyflavone Loaded Zein/Sophorolipid/Polysaccharide Ternary Nanoparticles: Comparison of Sodium Alginate and Sodium Carboxymethyl Cellulose

Chen

Peng

Wang

et al. 2021

Foods

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In this study, two polysaccharides [sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC)] were selected to establish zein/sophorolipid/ALG (ALG/S/Z) and zein/sophorolipid/ALG (CMC/S/Z) nanoparticles to encapsulate 7,8-dihydroxyflavone (7,8-DHF), respectively. The results showed that polysaccharide types significantly affected performance of ternary nanoparticles, including CMC/S/Z possessed lower polydispersity index, particle size and turbidity, but higher zeta potential, encapsulation efficiency and loading capacity compared to ALG/S/Z. Compared to zein/sophorolipid nanoparticles (S/Z), both ALG/S/Z and CMC/S/Z had better stability against low pH (pH 3~4) and high ionic strengths (150~200 mM NaCl). Hydrophobic effects, electrostatic interactions and hydrogen bonding were confirmed in ternary nanoparticles fabrication via Fourier-transform infrared spectroscopy. Circular dichroism revealed that CMC and ALG had no evident impact on secondary structure of zein in S/Z, but changed surface morphology of S/Z as observed by scanning electron microscope. Encapsulated 7,8-DHF exhibited an amorphous state in ternary nanoparticles as detected by X-ray diffraction and differential scanning calorimetry. Furthermore, compared to S/Z, ALG/S/Z, and CMC/S/Z remarkably improved the storage stability and bioaccessibility of 7,8-DHF. CMC/S/Z possessed a greater storage stability for 7,8-DHF, however, ALG/S/Z exhibited a better in vitro bioaccessibility of 7,8-DHF. This research provides a theoretical reference for zein-based delivery system application.

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Quercetagetin loaded in soy protein isolate–κ-carrageenan complex: Fabrication mechanism and protective effect

Cited by 61 publications

References 53 publications

The Rheolaser Master™ and Kinexus Rotational Rheometer® to Evaluate the Influence of Topical Drug Delivery Systems on Rheological Features of Topical Poloxamer Gel

The Rheolaser Master™ and Kinexus Rotational Rheometer® to Evaluate the Influence of Topical Drug Delivery Systems on Rheological Features of Topical Poloxamer Gel

Establishment and Characterization of Stable Zein/Glycosylated Lactoferrin Nanoparticles to Enhance the Storage Stability and in vitro Bioaccessibility of 7,8-Dihydroxyflavone

Development, Characterization, Stability and Bioaccessibility Improvement of 7,8-Dihydroxyflavone Loaded Zein/Sophorolipid/Polysaccharide Ternary Nanoparticles: Comparison of Sodium Alginate and Sodium Carboxymethyl Cellulose

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