QuEChERS-HPLC-DAD method for sulphonamides in chicken breast

Machado, Simone Caetani; Landin-Silva, Mariane; Maia, Paulo Henrique M.; Rath, Susanne; Martins, Ignez Salas

doi:10.1590/s1984-82502013000100017

Cited by 16 publications

(17 citation statements)

References 31 publications

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“…The quick easy cheap effective rugged safe (QuEChERS) method is an extraction technique that employs an organic solvent and phase separation using high salt content, in some cases followed by dispersive solid phase extraction (d-SPE) for sample clean up. The QuEChERS method, which was originally developed for pesticide analysis in fruits and vegetables [44,45], has recently been proposed for the analysis of veterinary drugs in different food matrices [4, 41,43,46]. Recent applications of this method are discussed below.…”

Section: Quechersmentioning

confidence: 99%

“…Machado et al [46] developed a QuEChERS method followed by analysis on the high performance liquid chromatography (HPLC) with a diode array detector (DAD) for the simultaneous determination of sulfadiazine, sulfamethoxazole and sulfamethoxypyridazine in chicken breast samples. The LODs ranged between 10 and 13 μg kg −1 and the LOQs ranged between 25 and 30 μg kg −1 while recoveries ranged between 75.4 and 98.7%.…”

Section: Class Of Veterinary Drugsmentioning

confidence: 99%

“…The matrix effect still remains an issue when extracting veterinary drug residues using the QuEChERS method from complex samples such as meat, and hence reducing the sensitivity of chromatographic instruments [46].…”

Section: Challenges and Future Trendsmentioning

confidence: 99%

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Modern Extraction and Cleanup Methods of Veterinary Drug Residues in Food Samples of Animal Origin

Moyo¹,

Tavengwa²

2019

Recent Advances in Analytical Chemistry

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Extensive research on the presence of veterinary drug residues in food samples has been conducted and is still underway. The inappropriate or excessive use of veterinary drugs in food producing animals may result in trace quantities of these drugs or their metabolites in food samples. Food contamination by veterinary drug residues is one of the main challenges worldwide to public health with drug resistance being the biggest threat. One of the challenges in veterinary drug residue analysis is their occurrence in trace amounts that are normally below limits of detection of most analytical instruments. Various efficient, economical, miniaturized and environmentally friendly extraction methods have been developed in recent years to pre-concentrate these analytes before instrumental analysis to enhance their detection and also to overcome the limitations of traditional extraction methods such as liquid-liquid extraction and solid phase extraction. These methods include quick, easy, cheap, effective, rugged and safe (QuEChERS), molecularly imprinted polymers, dispersive liquid-liquid microextraction and hollow fiber liquid-phase microextraction, and they will be discussed in this chapter.

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Section: Quechersmentioning

confidence: 99%

Section: Class Of Veterinary Drugsmentioning

confidence: 99%

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Modern Extraction and Cleanup Methods of Veterinary Drug Residues in Food Samples of Animal Origin

Moyo¹,

Tavengwa²

2019

Recent Advances in Analytical Chemistry

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“…Nevertheless, allergic reactions to these drugs are common, and residues should be monitored to ensure they are not present at levels above those considered safe. A QuEChERS-HPLC-DAD method for detecting sulfonamides in chicken breast was reported in 2013; the method attained LOQs below the MRL established by the European Community (100 µg/kg) and recoveries above 70% [ 4 ] by using buffering salts and concentrating the extract before analysis ( Figure 3 ). A similar study used HPLC/FLD and Z-Sep + as a sorbent instead [ 57 ], also achieving LOQs below the established MRL, but the recoveries for some sulfonamides were slightly lower than those of Machado et al [ 4 ].…”

Section: Application Of Quechers To Foods Of Animal Originmentioning

confidence: 99%

“…A QuEChERS-HPLC-DAD method for detecting sulfonamides in chicken breast was reported in 2013; the method attained LOQs below the MRL established by the European Community (100 µg/kg) and recoveries above 70% [ 4 ] by using buffering salts and concentrating the extract before analysis ( Figure 3 ). A similar study used HPLC/FLD and Z-Sep + as a sorbent instead [ 57 ], also achieving LOQs below the established MRL, but the recoveries for some sulfonamides were slightly lower than those of Machado et al [ 4 ]. A study using QuEChERS-LC-MS/MS described the simultaneous determination of 20 veterinary drug residues including several antibiotics and anthelmintics in chicken breast in less than 8.5 min [ 20 ].…”

Section: Application Of Quechers To Foods Of Animal Originmentioning

confidence: 99%

Application of QuEChERS for Determining Xenobiotics in Foods of Animal Origin

Garcia

Gotah

2017

Journal of Analytical Methods in Chemistry

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The use of pesticides and veterinary drugs results in the appearance of residues of xenobiotics in foods. Thus, several methods have been developed for monitoring them; however, most are tedious and expensive. By contrast, the QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) methodology involves a microextraction that yields small samples and has been applied for the analysis of various xenobiotics including pesticides, antibiotics, and mycotoxins. QuEChERS has shown advantages over other techniques including fast sample preparation, reduced needs for reagents and labware, and versatility. This approach allows the simultaneous determination of pesticides with various polarities and volatilities and can be easily modified for the analysis of a wide range of xenobiotics in various matrices including animal products rich in fat. Nevertheless, to attain high recoveries, the extraction, cleanup, and concentration steps have to be optimized according to the target compounds and matrix. Hence, QuEChERS is a promising and environmentally friendly methodology for the high-throughput routine analysis of xenobiotics in animal products. This review focuses on the application of QuEChERS to foods of animal origin and describes recent developments for the optimization of the analysis of veterinary drugs, pesticides, polycyclic aromatic hydrocarbons, and other compounds of concern.

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Quick, easy, cheap, effective, rugged, and safe sample preparation approach for pesticide residue analysis using traditional detectors in chromatography: A review

Rahman

El‐Aty

Kim

et al. 2016

J of Separation Science

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In pesticide residue analysis, relatively low-sensitivity traditional detectors, such as UV, diode array, electron-capture, flame photometric, and nitrogen-phosphorus detectors, have been used following classical sample preparation (liquid-liquid extraction and open glass column cleanup); however, the extraction method is laborious, time-consuming, and requires large volumes of toxic organic solvents. A quick, easy, cheap, effective, rugged, and safe method was introduced in 2003 and coupled with selective and sensitive mass detectors to overcome the aforementioned drawbacks. Compared to traditional detectors, mass spectrometers are still far more expensive and not available in most modestly equipped laboratories, owing to maintenance and cost-related issues. Even available, traditional detectors are still being used for analysis of residues in agricultural commodities. It is widely known that the quick, easy, cheap, effective, rugged, and safe method is incompatible with conventional detectors owing to matrix complexity and low sensitivity. Therefore, modifications using column/cartridge-based solid-phase extraction instead of dispersive solid-phase extraction for cleanup have been applied in most cases to compensate and enable the adaptation of the extraction method to conventional detectors. In gas chromatography, the matrix enhancement effect of some analytes has been observed, which lowers the limit of detection and, therefore, enables gas chromatography to be compatible with the quick, easy, cheap, effective, rugged, and safe extraction method. For liquid chromatography with a UV detector, a combination of column/cartridge-based solid-phase extraction and dispersive solid-phase extraction was found to reduce the matrix interference and increase the sensitivity. A suitable double-layer column/cartridge-based solid-phase extraction might be the perfect solution, instead of a time-consuming combination of column/cartridge-based solid-phase extraction and dispersive solid-phase extraction. Therefore, replacing dispersive solid-phase extraction with column/cartridge-based solid-phase extraction in the cleanup step can make the quick, easy, cheap, effective, rugged, and safe extraction method compatible with traditional detectors for more sensitive, effective, and green analysis.

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QuEChERS-HPLC-DAD method for sulphonamides in chicken breast

Cited by 16 publications

References 31 publications

Modern Extraction and Cleanup Methods of Veterinary Drug Residues in Food Samples of Animal Origin

Modern Extraction and Cleanup Methods of Veterinary Drug Residues in Food Samples of Animal Origin

Application of QuEChERS for Determining Xenobiotics in Foods of Animal Origin

Quick, easy, cheap, effective, rugged, and safe sample preparation approach for pesticide residue analysis using traditional detectors in chromatography: A review

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