Quaternary tannic acid with improved leachability and biocompatibility for antibacterial medical thermoplastic polyurethane catheters

Wang, Yue; Liu, Shuaizhen; Ding, Xuejia; Zhang, Yaocheng; Ding, Xuejia; Mi, Jianguo

doi:10.1039/d1tb00227a

Cited by 31 publications

(30 citation statements)

References 55 publications

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“…At the same time, it maintains the flexibility to allow flexion/bending despite intrathoracic pressure differences during breathing cycles [63,64]. TPU is known to have flexibility and is widely used in soft tissue engineering [23,24,65,66]. The present study revealed that the tensile strength and Youngs' modulus of TPU were proportionately increased when PLA was added.…”

Section: Mechanical Propertiesmentioning

confidence: 63%

Mechanical Properties and In Vitro Evaluation of Thermoplastic Polyurethane and Polylactic Acid Blend for Fabrication of 3D Filaments for Tracheal Tissue Engineering

et al. 2021

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Surgical reconstruction of extensive tracheal lesions is challenging. It requires a mechanically stable, biocompatible, and nontoxic material that gradually degrades. One of the possible solutions for overcoming the limitations of tracheal transplantation is a three-dimensional (3D) printed tracheal scaffold made of polymers. Polymer blending is one of the methods used to produce material for a trachea scaffold with tailored characteristics. The purpose of this study is to evaluate the mechanical and in vitro properties of a thermoplastic polyurethane (TPU) and polylactic acid (PLA) blend as a potential material for 3D printed tracheal scaffolds. Both materials were melt-blended using a single screw extruder. The morphologies (as well as the mechanical and thermal characteristics) were determined via scanning electron microscopy (SEM), Fourier Transform Infrared (FTIR) spectroscopy, tensile test, and Differential Scanning calorimetry (DSC). The samples were also evaluated for their water absorption, in vitro biodegradability, and biocompatibility. It is demonstrated that, despite being not miscible, TPU and PLA are biocompatible, and their promising properties are suitable for future applications in tracheal tissue engineering.

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Section: Mechanical Propertiesmentioning

confidence: 63%

Mechanical Properties and In Vitro Evaluation of Thermoplastic Polyurethane and Polylactic Acid Blend for Fabrication of 3D Filaments for Tracheal Tissue Engineering

et al. 2021

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“…Antibacterial properties of medical catheters mainly include antibacterial adhesion and sterilization. At present, the construction of antibacterial catheter surfaces is mainly achieved via three methods: coating, grafting, and bulk modification [73][74][75][76]. The coating is mainly achieved by physical modification, that is, the antibacterial agent is physically adsorbed to the polymer surface through non-covalent bonds, including electrostatic interaction, van der Waals force, hydrophobic interaction, multidentate ligands, and π-π stacking [77,78].…”

Section: Medical Cathetersmentioning

confidence: 99%

Antibacterial surfaces: Strategies and applications

Yang

Hou

Tian

et al. 2022

Sci. China Technol. Sci.

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Antibacterial surfaces are surfaces that can resist bacteria, relying on the nature of the material itself. It is significant for safe food and water, human health, and industrial equipment. Biofilm is the main form of bacterial contamination on the material surface. Preventing the formation of biofilm is an efficient way to develop antibacterial surfaces. The strategy for constructing the antibacterial surface is divided into bacteria repelling and bacteria killing based on the formation of the biofilm. Material surface wettability, adhesion, and steric hindrance determine bacteria repelling performance. Bacteria should be killed by surface chemistry or physical structures when they are attached to a material surface irreversibly. Killing approaches are usually in the light of the cell membrane of bacteria. This review summarizes the fabrication methods and applications of antibacterial surfaces from the view of the treatment of the material surfaces. We also present several crucial points for developing long-term stability, no drug resistance, broad-spectrum, and even programable antibacterial surfaces.

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“…To form an ultrathin coating, we focused on TAa polyphenol with a glucose corethat has been shown to rapidly assemble into structured thin films in the presence of metal ions such as Fe 3+ . ,, TA molecules interact with Fe ions via coordination bonding and form stable films of defined thickness. TA is a common food additive present in green tea or wine and, therefore, has excellent biocompatibility. , We envisioned that a TA film would overcoat a microcapsule as shown in Figure A. However, before proceeding to microcapsule coating, we wanted to characterize properties of a TA film under better-controlled conditions using surface analysis approaches.…”

Section: Resultsmentioning

confidence: 99%

Coating Bioactive Microcapsules with Tannic Acid Enhances the Phenotype of the Encapsulated Pluripotent Stem Cells

Choi

Gwon

Hong

et al. 2022

ACS Appl. Mater. Interfaces

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Human pluripotent stem cells (hPSCs) may be differentiated into any adult cell type and therefore hold incredible promise for cell therapeutics and disease modeling. There is increasing interest in three-dimensional (3D) hPSC culture because of improved differentiation outcomes and potential for scale up. Our team has recently described bioactive heparin (Hep)-containing core–shell microcapsules that promote rapid aggregation of stem cells into spheroids and may also be loaded with growth factors for the local and sustained delivery to the encapsulated cells. In this study, we explored the possibility of further modulating bioactivity of microcapsules through the use of an ultrathin coating composed of tannic acid (TA). Deposition of the TA film onto model substrates functionalized with Hep and poly(ethylene glycol) was characterized by ellipsometry and atomic force microscopy. Furthermore, the presence of the TA coating was observed to increase the amount of basic fibroblast growth factor (bFGF) incorporation by up to twofold and to extend its release from 5 to 7 days. Most significantly, TA-microcapsules loaded with bFGF induced higher levels of pluripotency expression compared to uncoated microcapsules containing bFGF. Engineered microcapsules described here represent a new stem cell culture approach that enables 3D cultivation and relies on local delivery of inductive cues.

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Quaternary tannic acid with improved leachability and biocompatibility for antibacterial medical thermoplastic polyurethane catheters

Abstract: Surfaces of indwelling catheters offer sites for the adherence of bacteria to form biofilms, leading to various infections. Therefore, the development of antibacterial materials for catheters is imperative. In this...

Cited by 31 publications

References 55 publications

Mechanical Properties and In Vitro Evaluation of Thermoplastic Polyurethane and Polylactic Acid Blend for Fabrication of 3D Filaments for Tracheal Tissue Engineering

Mechanical Properties and In Vitro Evaluation of Thermoplastic Polyurethane and Polylactic Acid Blend for Fabrication of 3D Filaments for Tracheal Tissue Engineering

Antibacterial surfaces: Strategies and applications

Coating Bioactive Microcapsules with Tannic Acid Enhances the Phenotype of the Encapsulated Pluripotent Stem Cells

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