Quaternary Silsesquioxane: A Developmental Toxicity Study in Rats

Siddiqui, Waheed H.; YORK, RAYMOND G.

doi:10.1093/toxsci/21.1.66

Cited by 6 publications

(5 citation statements)

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“…αCD was chosen for the possibility to easily design a fucoside that matches FleA valency with all six sugars presented on the primary face. Polyhedral silsesquioxanes are emerging as versatile platforms for the design of multivalent compounds; furthermore, pharmaceutical studies suggest that the organosilica core has low intrinsic toxicity . Here, COSS functionalization should allow for a homogeneous distribution of the grafted sugars.…”

Section: Resultsmentioning

confidence: 99%

Multivalent Fucosides with Nanomolar Affinity for the Aspergillus fumigatus Lectin FleA Prevent Spore Adhesion to Pneumocytes

Lehot

Brissonnet

Dussouy

et al. 2018

Chemistry A European J

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FleA (or AFL), a fucose lectin, was recently identified in the opportunistic mold Aspergillus fumigatus, which causes fatal lung infections in immunocompromised patients. We designed di‐, hexa‐ and octavalent fucosides with various spacer arm lengths to block the hexameric FleA through chelation. Microcalorimetry measurements showed that the ethylene glycol (EG) spacer arm length has a strong influence on the binding affinity of the divalent fucosides. The relationship between the EG length and chelate binding efficiency to FleA was explored according to polymer theory. Hexa‐ and octavalent compounds based on cyclodextrin and octameric silsesquioxane scaffolds were nanomolar FleA inhibitors, surpassing their monovalent fucose analogue by more than three orders of magnitude. Importantly, some of the fucosides were highly efficient in preventing fungal spore adhesion to bronchoepithelial cells, with half maximal inhibitory concentration values in the micromolar range. We propose that the synergistic antiadhesive effect observed can be ascribed to chelate binding to FleA and to the formation of conidium aggregates, as observed by optical microscopy. These fucosides are promising tools that can be used to better understand the role of FleA in conidia pathogenicity and host defenses against invasive aspergillosis.

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Section: Resultsmentioning

confidence: 99%

Multivalent Fucosides with Nanomolar Affinity for the Aspergillus fumigatus Lectin FleA Prevent Spore Adhesion to Pneumocytes

Lehot

Brissonnet

Dussouy

et al. 2018

Chemistry A European J

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“…Application areas as additives to silicone paint commonly used in hospitals [ 96 , 102 ], to methacrylate glass [ 103 ], as ceramic water filters [ 104 ], and as anti-biofouling coatings with polydimethylsiloxane for the marine industry [ 102 ] have been presented, to name a few. Siddiqui and York have examined the toxicity of quaternary silsesquioxane on rats and stated that oral administration as high as 1000 mg/kg/day did not produce teratogenicity or other indications of developmental toxicity [ 105 ]. Q-POSS copolymers with polyurethanes seem to be a promising direction, especially as biodegradable materials used in biomedical fields [ 15 , 106 , 107 , 108 , 109 , 110 , 111 ].…”

Section: Biomedical Applications Of Pu/possmentioning

confidence: 99%

Recent Advances in Polyurethane/POSS Hybrids for Biomedical Applications

Ozimek

Pielichowski

2021

Molecules

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Advanced organic-inorganic materials-composites, nanocomposites, and hybrids with various compositions offer unique properties required for biomedical applications. One of the most promising inorganic (nano)additives are polyhedral oligomeric silsesquioxanes (POSS); their biocompatibility, non-toxicity, and phase separation ability that modifies the material porosity are fundamental properties required in modern biomedical applications. When incorporated, chemically or physically, into polyurethane matrices, they substantially change polymer properties, including mechanical properties, surface characteristics, and bioactivity. Hence, this review is dedicated to POSS-PU composites that have recently been developed for applications in the biomedical field. First, different modes of POSS incorporation into PU structure have been presented, then recent developments of PU/POSS hybrids as bio-active composites for scaffolds, cardiovascular stents, valves, and membranes, as well as in bio-imaging and cancer treatment, have been described. Finally, characterization and methods of modification routes of polyurethane-based materials with silsesquioxanes were presented.

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“…One of the most prevalent and studied nanosized POSS is the well‐defined and symmetrical T 8 structure (hexahedral octasilsesquioxane (RSiO 1.5 ) 8 )—abbreviated as COSS for Cubic Octameric SilSesquioxane—which possesses a compact and rigid three‐dimensional cage‐like structure made of an inorganic silica‐like core flanked with eight functionalizable organic groups at the corners . COSS is a monodisperse hybrid system of nanometric size with a precise number of functional groups which, thanks to its biocompatibility and low toxicity, is currently finding increasing applications in biological sciences, for instance in drug delivery, as anti‐cancer drug, and in biomedical imaging . This versatile class of organosilica compounds are indeed of great value as platforms for accessing multivalent conjugates for biomolecular recognition or enzyme inhibition, providing effective synthetic methods to afford their complete functionalization …”

Section: Figurementioning

confidence: 99%

Polyhedral Oligomeric Silsesquioxane (POSS) Bearing Glyoxylic Aldehyde as Clickable Platform Towards Multivalent Conjugates

Kanfar

Mehdi

Dumy

et al. 2017

Chemistry A European J

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The straightforward access to octafunctional "cubic" silsesquioxane platform grafter with pendant glyoxylic aldehydes is described. This clickable hybrid platform readily reacts with oxyamine or hydrazide compounds to provide, respectively, oxime and acylhydrazone conjugates, thereby offering a new and effective access from which one can elaborate multivalent systems for the targeting of biomolecules of interest.

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Quaternary Silsesquioxane: A Developmental Toxicity Study in Rats

Cited by 6 publications

References 0 publications

Multivalent Fucosides with Nanomolar Affinity for the Aspergillus fumigatus Lectin FleA Prevent Spore Adhesion to Pneumocytes

Multivalent Fucosides with Nanomolar Affinity for the Aspergillus fumigatus Lectin FleA Prevent Spore Adhesion to Pneumocytes

Recent Advances in Polyurethane/POSS Hybrids for Biomedical Applications

Polyhedral Oligomeric Silsesquioxane (POSS) Bearing Glyoxylic Aldehyde as Clickable Platform Towards Multivalent Conjugates

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