Concentrations of secondary clay minerals (mica, vermiculite, montmorillonite, chlorite, and kaolinite) in the A horizon of 99 U.S. soils were used in a stepwise regression with climate, parent material, and soil property variables to develop models of the occurrence and abundance of each clay mineral species. Climate-especially water balance estimates of soil water surplus, water deficit, and indicators of seasonality-were especially useful variables. These models correctly predicted the dominant (most abundant) clay minerals for 80 of the 99 sites even though the RZ values for individual clays were modest. Maps of predicted and actual clay dominance are in good agreement. In addition, the models may be used to devise a weathering sequence of clay minerals from least to most stable (i.e., mica < montmorillonite < vermiculite < kaolinite). Weathering sequences based on existing models place vermiculite before montmorillonite. The models in this study suggest that vermiculite with aluminum as the interlaying cation is common in U.S. soils and is formed in a more intense weathering environment than is montmorillonite; vermiculite should therefore follow montmorillonite in the weathering sequence. This result agrees with many field studies and suggests that the generally accepted sequences need additions and revision. Finally these models support geochemical theories that imply that seasonal wetting and drying are important controls of the formation of secondary clay minerals.